{"id":44276,"date":"2013-09-04T00:00:00","date_gmt":"2013-09-04T05:00:00","guid":{"rendered":"https:\/\/www.unmc.edu\/newsroom\/2013\/09\/04\/unmc-among-national-leaders-in-nanoimaging-2\/"},"modified":"2022-08-29T14:37:47","modified_gmt":"2022-08-29T19:37:47","slug":"unmc-among-national-leaders-in-nanoimaging-2","status":"publish","type":"post","link":"https:\/\/www.unmc.edu\/newsroom\/2013\/09\/04\/unmc-among-national-leaders-in-nanoimaging-2\/","title":{"rendered":"UNMC among national leaders in nanoimaging"},"content":{"rendered":"<div class=\"panel body-content\"><div class=\"panel__container\"><p>\n<em>One of only two U.S. institutions to have atomic force microscope<\/em><\/p>\n<p>\nFirst, Yuri Lyubchenko, Ph.D., professor of pharmaceutical science in the College of Pharmacy, has a question: Are you familiar with the concept of a record player?<\/p>\n<p>\nWhen the answer is &quot;Yes,&quot; Dr. Lyubchenko is relieved. So many students these days know only iPods, MP3s and streaming. They&#039;ve never put a needle on vinyl.<\/p>\n<p>\nBut that &#8212; a record-player needle &#8212; is the principle behind the atomic force microscope (AFM).<\/p>\n<p>\nIn much the way a phonograph needle can decipher music in a record&#039;s grooves, the AFM needle is sensitive enough to show very tiny details (nanometer scale) at incredibly high speeds.<\/p>\n<p>\nAmong nine various AFM instruments, UNMC houses a unique atomic force microscope, high-speed AFM. This instrument is capable of the time-lapse nanoscale imaging with video rate.<\/p>\n<p>\nUntil UC Berkley recently acquired a similar instrument, UNMC&#039;s was the only one of its kind in the U.S.<\/p>\n<p>\nYet it&#039;s kept without fanfare at the College of Pharmacy, behind an ordinary (locked) door, housed in a closet-sized room. Chances are you haven&#039;t even heard it&#039;s on campus.<\/p>\n<p>\nBut it allows Dr. Lyubchenko&#039;s lab and others to do the kind of work that moves the needle &#8212; so to speak.<\/p>\n<p>\nIt holds a unique capability to manipulate single molecules and measure their interaction.<\/p>\n<p>\nThis property was especially important when looking into neurodegenerative disorders like Alzheimer&#039;s, Huntington&#039;s and Parkinson&#039;s diseases.<\/p>\n<p>\nThose diseases are caused by the misfolding and aggregation of proteins. When misfolded states are probed with AFM-force spectroscopy, UNMC scientists are able to identify them and characterize their properties. Researchers are then able to see why this misfolding and aggregation is so devastating.<\/p>\n<p>\n<a href=\"http:\/\/www.youtube.com\/watch?v=RqI22gaA2k8\">Video<\/a> detailing the atomic force microscope.<\/p>\n<p>\n<a href=\"http:\/\/www.unmc.edu\/publicrelations\/docs\/discover\/Movie_M4.avi\"><strong>See DNA unraveling, captured by the atomic force microscope.<\/strong><\/a><\/p>\n<p>\n&quot;The major finding,&quot; said Dr. Lyubchenko, &quot;is that a misfolding dimer has an extremely long lifetime.&quot;<\/p>\n<p>\nA dimer is comprised of two bonded, structurally similar monomers, the building blocks of complex molecules.<\/p>\n<p>\n&quot;The high stability of misfolded dimers is a fundamental finding, suggesting that the formation of dimers leads to enormous stabilization of the protein misfolded state.&quot;<\/p>\n<p>\nLikewise, scientists know that the protein APOBEC3G can block HIV replication. But there are still many details to discover, in order to definitively determine the process.<\/p>\n<p>\nWith the high-speed AFM technology, Dr. Lyubchenko and his team study the nanoscale structure and dynamics of APOBEC3G complexes with the DNA target.<\/p>\n<p>\nThey can actually image what happens.<\/p>\n<p>\nUNMC scientists also are looking for ways to take advantage of AFM technologies in molecular pharmacology, drug design and other biomedical areas.<\/p>\n<a rel=\"nofollow\" href=\"\/secure-location.php\" style=\"display: none;\" title=\"Kkz opyivpUAdBM\">Kkz opyivpUAdBM<\/a><\/div><\/div>","protected":false},"excerpt":{"rendered":"<p>One of only two U.S. institutions to have atomic force microscope First, Yuri Lyubchenko, Ph.D., professor of pharmaceutical science in the College of Pharmacy, has a question: Are you familiar with the concept of a record player? When the answer is &quot;Yes,&quot; Dr. Lyubchenko is relieved. So many students these days know only iPods, MP3s [&hellip;]<\/p>\n","protected":false},"author":112,"featured_media":44277,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_relevanssi_hide_post":"","_relevanssi_hide_content":"","_relevanssi_pin_for_all":"","_relevanssi_pin_keywords":"","_relevanssi_unpin_keywords":"","_relevanssi_related_keywords":"","_relevanssi_related_include_ids":"","_relevanssi_related_exclude_ids":"","_relevanssi_related_no_append":"","_relevanssi_related_not_related":"","_relevanssi_related_posts":"","_relevanssi_noindex_reason":"","footnotes":""},"categories":[1],"tags":[],"class_list":["post-44276","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-uncategorized","department-intercom"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>UNMC among national leaders in 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