{"id":44293,"date":"2013-09-04T00:00:00","date_gmt":"2013-09-04T05:00:00","guid":{"rendered":"https:\/\/www.unmc.edu\/newsroom\/2013\/09\/04\/unmc-coordinating-12-2-million-study-on-abdominal-aortic-aneurysms\/"},"modified":"2022-08-29T14:37:50","modified_gmt":"2022-08-29T19:37:50","slug":"unmc-coordinating-12-2-million-study-on-abdominal-aortic-aneurysms","status":"publish","type":"post","link":"https:\/\/www.unmc.edu\/newsroom\/2013\/09\/04\/unmc-coordinating-12-2-million-study-on-abdominal-aortic-aneurysms\/","title":{"rendered":"UNMC coordinating $12.2 million study on abdominal aortic aneurysms"},"content":{"rendered":"

\nWill investigate low-cost antibiotic to determine if it can inhibit enzymes that cause aneurysms<\/em><\/strong><\/p>\n

\nWhen diagnosed with an abdominal aortic aneurysm, all most people can do is worry, watch and wait. Timothy Baxter, M.D.,<\/a> professor of surgery at the University of Nebraska Medical Center<\/a>, has compared it to being forced to live with the ticking of a time bomb.<\/p>\n

\nIt can take years before an aneurysm is recommended for repair – when it finally grows large enough (about 5.5 cm) that the risk of rupture outweighs the risk of surgery.<\/p>\n

\n“This approach is very unsettling to patients,” Dr. Baxter said.<\/p>\n

\n“Some people, every day they wake up worrying about it,” agreed UNMC’s Jason MacTaggart, M.D.<\/a>,<\/u> “because even though most abdominal aortic aneurysms rupture at a size greater than about 5 and a half centimeters (2 inches), they can sometimes be unpredictable and cause problems even when small.”<\/p>\n

\nMost would rather do something, anything. Now, at least a few of them can.<\/p>\n

\nUNMC is the clinical coordinating center for a $12.2 million multi-center randomized placebo-controlled clinical trial of medical management of aortic aneurysm disease.<\/p>\n

\nThe management would be via a pill, which some scientists believe could significantly slow aneurysm growth. The study is being conducted under the auspices of a grant from the National Institutes of Health.<\/p>\n

\nThe Non-Invasive Treatment of Abdominal Aortic Aneurysm Clinical Trial (NTA3<\/sup>CT)<\/a> aims to enroll 250 patients with the collaboration of 15 top academic medical centers across the U.S.<\/p>\n

\nIn addition to UNMC, the project’s pillar institutions include the University of Maryland Medical Center<\/a> – for clinical trials management and design; University of Wisconsin School of Medicine and Public Health<\/a> – for aortic imaging; and Washington University School of Medicine in St. Louis<\/a> – for blood, lab and genetic testing.<\/p>\n

\nFifty percent of the trial’s enrollees will receive the antibiotic doxycycline, an inexpensive generic now widely used for acne and other conditions. Dr. Baxter’s preliminary research in animal models shows the drug inhibits the enzymes which weaken aortic walls, thus causing aneurysms.<\/p>\n

\nIf successful, it’s an inexpensive, noninvasive, proactive approach.<\/p>\n

\nDr. MacTaggart, a vascular surgeon, said the surgery to repair aneurysms can come with a mortality rate of up to 3 percent – and a cost of about $20,000. More than 40,000 such procedures are done each year nationwide.<\/p>\n

\n“Multiply all of that together,” Dr. MacTaggart said. “If you can change a $100,000 operation to $10 a year for some pills, it’s going to save the health care system a ton<\/em> of money.”<\/p>\n

\nBut, the study will show more than whether or not the pill works. It should also garner a host of invaluable information.<\/p>\n

\nAnd its enrollees will be doing something about the disease, rather than just biding time.<\/p>\n

\nAortic aneurysms affect 3 percent to 5 percent of the population, but are most common in men age 65 and older, often smokers with a family history.<\/p>\n

\n"It's considered a silent killer," Dr. Baxter said, "because there are no symptoms until it ruptures. Most aneurysms we find by luck when imaging is done for other medical conditions."<\/p>\n

\nAnd then, there is only worrying and waiting as it grows. Nothing you can do.<\/p>\n

\nUntil now.<\/p>\n

\nAcademic health science centers enrolling patients in the clinical trial:<\/strong>
\nBaptist Health Medical Center, Miami, Fla.
\nBeth Israel Deaconess Medical Center (Harvard University), Boston
\nCleveland Clinic Lerner College of Medicine, Cleveland, Ohio
\nGeisinger Medical Center, Danville, Penn.
\nColumbia University Medical Center, New York
\nNorthwestern University, Chicago
\nOregon Health and Science University, Portland
\nUniversity of Arizona Health Sciences Center, Tucson, Ariz.
\nUniversity of Cincinnati College of Medicine, Cincinnati, Ohio
\nUniversity of Maryland School of Medicine, Baltimore
\nUniversity of Michigan, Ann Arbor, Mich.
\nUniversity of Nebraska Medical Center, Omaha, Neb.
\nUniversity of Utah Health Sciences Center, Salt Lake City
\nUniversity of South Florida Health South, Tampa, Fla.
\nWashington University School of Medicine, St. Louis, Mo.<\/p>\n

\nNational principal investigators:<\/strong><\/p>\n

\nClinical Coordinating Center Director<\/strong>
\nTimothy Baxter, M.D.
\nProfessor, department of surgery
\nUniversity of Nebraska Medical Center<\/p>\n

\nData Coordinating Center Director<\/strong>
\nMichael Terrin, M.D., M.P.H.
\nProfessor, department of epidemiology and public health
\nUniversity of Maryland School of Medicine <\/p>\n

\nImaging Core Laboratory Director <\/strong>
\nJon Matsumura, M.D.
\nProfessor and chairman, division of vascular surgery
\nMedical director, AortaCore Imaging Lab
\nUniversity of Wisconsin School of Medicine and Public Health <\/p>\n

\nBiomarkers Core Lab Director<\/strong>
\nJohn Curci, M.D.
\nAssociate professor, department of surgery
\nWashington University in St. Louis<\/p>\n<\/div><\/div>","protected":false},"excerpt":{"rendered":"

Will investigate low-cost antibiotic to determine if it can inhibit enzymes that cause aneurysms When diagnosed with an abdominal aortic aneurysm, all most people can do is worry, watch and wait. Timothy Baxter, M.D., professor of surgery at the University of Nebraska Medical Center, has compared it to being forced to live with the ticking […]<\/p>\n","protected":false},"author":112,"featured_media":44294,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_relevanssi_hide_post":"","_relevanssi_hide_content":"","_relevanssi_pin_for_all":"","_relevanssi_pin_keywords":"","_relevanssi_unpin_keywords":"","_relevanssi_related_keywords":"","_relevanssi_related_include_ids":"","_relevanssi_related_exclude_ids":"","_relevanssi_related_no_append":"","_relevanssi_related_not_related":"","_relevanssi_related_posts":"","_relevanssi_noindex_reason":"","footnotes":""},"categories":[1],"tags":[],"class_list":["post-44293","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-uncategorized","department-intercom"],"yoast_head":"\nUNMC coordinating $12.2 million study on abdominal aortic 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