{"id":46948,"date":"2001-10-23T00:00:00","date_gmt":"2001-10-23T05:00:00","guid":{"rendered":"https:\/\/www.unmc.edu\/newsroom\/2001\/10\/23\/researchers-study-new-approach-to-preventing-treatingosteoporosis-in-breast-cancer-survivors\/"},"modified":"2022-08-29T10:51:09","modified_gmt":"2022-08-29T15:51:09","slug":"researchers-study-new-approach-to-preventing-treatingosteoporosis-in-breast-cancer-survivors","status":"publish","type":"post","link":"https:\/\/www.unmc.edu\/newsroom\/2001\/10\/23\/researchers-study-new-approach-to-preventing-treatingosteoporosis-in-breast-cancer-survivors\/","title":{"rendered":"Researchers Study New Approach to Preventing, Treating\n\nOsteoporosis In Breast Cancer Survivors"},"content":{"rendered":"

Researchers at the University of Nebraska Medical Center College of<\/p>\n

Nursing are involved in a study to evaluate a new approach in preventing<\/p>\n

and treating osteoporosis in breast cancer survivors.<\/p>\n

As a result of chemotherapy, at least 50 percent of women who are diagnosed<\/p>\n

with breast cancer under age 50 experience premature ovarian failure that<\/p>\n

leads to early menopause. Because estrogen influences growth of breast<\/p>\n

cancer in women with estrogen receptor positive cancers, women with a history<\/p>\n

of breast cancer are often not candidates for hormone replacement therapy,<\/p>\n

the most effective preventive treatment for osteoporosis.<\/p>\n

Osteoporosis causes deterioration of bone tissue, which leads to bone<\/p>\n

fragility and an increased susceptibility to fractures of the hip, spine<\/p>\n

and wrist, according to the National Osteoporosis Foundation. The disease<\/p>\n

is a major public health threat for more than 28 million Americans, 80<\/p>\n

percent of whom are women. An average of 24 percent of hip fracture patients<\/p>\n

age 50 and over die in the year following their fracture. Caucasian and<\/p>\n

Asian women are at increased risk for osteoporosis.<\/p>\n

This is a  really significant problem. The good news is that more<\/p>\n

women are surviving breast cancer than ever before, said Nancy Waltman,<\/p>\n

Ph.D., associate professor of nursing, UNMC College of Nursing Lincoln<\/p>\n

Division and principal investigator of the study. Unfortunately, they<\/p>\n

have another concern — they may be at greater risk of osteoporosis than<\/p>\n

healthy women, and the onset of osteoporosis may occur at an earlier age.<\/p>\n

The purpose of the one-year study is to evaluate the feasibility and<\/p>\n

effectiveness of a multi-component intervention in post-menopausal women<\/p>\n

between the ages of 40 and 65 years, who have completed treatment for early<\/p>\n

stage breast cancer and who cannot receive hormone replacement therapy<\/p>\n

(HRT). Specific objectives of the pilot study are to determine adherence<\/p>\n

of the intervention, and to look at differences between the groups such<\/p>\n

as quality of life and vigor, and outcomes such as bone mineral density,<\/p>\n

muscle strength and activity level.<\/p>\n

Women in Omaha, Kearney and Scottsbluff will participate in the study.<\/p>\n

The study is funded by the Regional West Foundation of Scottsbluff,<\/p>\n

Neb., and national organizations: Oncology Nursing Foundation; Sigma Theta<\/p>\n

Tau International Honor Society of Nursing; and the American Nurses Foundation.<\/p>\n

The study will evaluate a group of 30 women who will taking calcium<\/p>\n

with vitamin D, and Fosamax®, a drug shown to rebuild bone mass. Women<\/p>\n

also participate in strength and weight training exercises and receive<\/p>\n

education on osteoporosis as well as strategies to promote adherence to<\/p>\n

the intervention. A control group of seven to 12 women will follow the<\/p>\n

same protocol but without strength and weight training.<\/p>\n

Eligible study participants will receive evaluations, including muscle<\/p>\n

strength and balance tests and bone mineral density screenings using Dual-Energy<\/p>\n

X-ray Absorptiometry (DEXA). DEXA screening is painless, takes less than<\/p>\n

15 minutes and doesnt require clothes removal. Women will be evaluated<\/p>\n

at various intervals during the study.<\/p>\n

Researchers say the study is unique because it combines exercise with<\/p>\n

other components used in the fight against osteoporosis — calcium, vitamin<\/p>\n

D and drugs that build bone mass.<\/p>\n

We want to know how much exercise improves on the effects of the medication,<\/p>\n

said Janice Twiss, Ph.D., UNMC associate professor of nursing and womens<\/p>\n

health nurse practitioner and co-principal investigator of the study. Dr.<\/p>\n

Twiss said a strength-weight training program will be used to strengthen<\/p>\n

muscle and bone mass in the hip, spine and wrist.<\/p>\n

After age 65, women who arent on HRT are at great risk for osteoporotic<\/p>\n

fractures, said Twiss said. Women whove had breast cancer and have gone<\/p>\n

through chemotherapy have a longer period of time where bone is lost.<\/p>\n

She said there is a growing concern in regards to osteoporosis as people<\/p>\n

live longer. The estimated annual cost of osteoporosis is $15 to 20 million<\/p>\n

annually.<\/p>\n

Its a more expensive chronic illness than congestive heart failure<\/p>\n

and asthma, Dr. Twiss said. Women can live a long time, but theyre disabled.<\/p>\n

They end up in a nursing home.<\/p>\n

She said women get fractures in their spine simply by reaching up to<\/p>\n

get something, sneezing or walking down steps. Most often, hip fractures<\/p>\n

usually occur with a fall.<\/p>\n

An important part of the study evaluates study participants adherence<\/p>\n

with components of the study. Weve recognized that adherence not only<\/p>\n

to exercise, but to medications, is a problem. So weve included strategies<\/p>\n

to improve adherence, Dr. Waltman said.<\/p>\n

Information gathered from this study will be used for a larger study.<\/p>\n

In June, Drs. Waltman and Twiss published baseline results of bone mineral<\/p>\n

density in postmenopausal breast cancer survivors in the Journal of the<\/p>\n

American Academy of Nurse Practitioners. They were surprised to find 80<\/p>\n

percent of the women had signs of osteopenia or osteoporosis and about<\/p>\n

45 percent were not aware they had a problem because theyd never been<\/p>\n

told.<\/p>\n

Very few women had bone mineral density measurements before the study,<\/p>\n

Dr. Waltman said. Many of these women didnt even realize that osteoporosis<\/p>\n

was something they should be concerned about it. The findings suggest the<\/p>\n

need for health care providers to educate breast cancer survivors or women<\/p>\n

not on hormone replacement therapy that they are at risk for osteoporosis<\/p>\n

and they should be screened.<\/p>\n

Other researchers participating in the study are: Carol Ott, Ph.D.,<\/p>\n

UNMC College of Nursing Kearney Division; Gloria Gross, Ph.D., UNMC College<\/p>\n

of Nursing West Nebraska Division; Ada Lindsey, Ph.D., UNMC College of<\/p>\n

Nursing, Omaha; and Timothy Moore, M.D., UNMC College of Medicine, Omaha.<\/p>\n

 <\/p>\n<\/div><\/div>","protected":false},"excerpt":{"rendered":"

Researchers at the University of Nebraska Medical Center College of Nursing are involved in a study to evaluate a new approach in preventing and treating osteoporosis in breast cancer survivors. As a result of chemotherapy, at least 50 percent of women who are diagnosed with breast cancer under age 50 experience premature ovarian failure that […]<\/p>\n","protected":false},"author":79,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_relevanssi_hide_post":"","_relevanssi_hide_content":"","_relevanssi_pin_for_all":"","_relevanssi_pin_keywords":"","_relevanssi_unpin_keywords":"","_relevanssi_related_keywords":"","_relevanssi_related_include_ids":"","_relevanssi_related_exclude_ids":"","_relevanssi_related_no_append":"","_relevanssi_related_not_related":"","_relevanssi_related_posts":"","_relevanssi_noindex_reason":"","footnotes":""},"categories":[1],"tags":[],"class_list":["post-46948","post","type-post","status-publish","format-standard","hentry","category-uncategorized","department-press-release"],"yoast_head":"\nResearchers Study New Approach to Preventing, Treating Osteoporosis In Breast Cancer 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