{"id":46963,"date":"2003-06-19T00:00:00","date_gmt":"2003-06-19T05:00:00","guid":{"rendered":"https:\/\/www.unmc.edu\/newsroom\/2003\/06\/19\/unmc-to-highlight-new-form-of-creatine-at-biotechnologyconvention-in-washington-d-c\/"},"modified":"2022-08-29T10:44:13","modified_gmt":"2022-08-29T15:44:13","slug":"unmc-to-highlight-new-form-of-creatine-at-biotechnologyconvention-in-washington-d-c","status":"publish","type":"post","link":"https:\/\/www.unmc.edu\/newsroom\/2003\/06\/19\/unmc-to-highlight-new-form-of-creatine-at-biotechnologyconvention-in-washington-d-c\/","title":{"rendered":"UNMC to highlight new form of creatine at biotechnology\n\nconvention in Washington, D.C."},"content":{"rendered":"<div class=\"panel body-content\"><div class=\"panel__container\"><p>In the scientific community, the invention of Gatorade in 1965 by a<\/p>\n<p>team of researchers at the University of Florida is a landmark event. By<\/p>\n<p>creating a drink that rapidly replaced lost fluids and helped prevent dehydration,<\/p>\n<p>the University of Florida opened the door to a windfall of royalties that<\/p>\n<p>brought millions of dollars back to the university.<\/p>\n<p>At the University of Nebraska Medical Center and other research centers<\/p>\n<p>around the country, the Gatorade story serves as an inspiration to what<\/p>\n<p>can happen if research results in a breakthrough discovery.<\/p>\n<p>This weekend, a contingent of Nebraskans will travel to Washington,<\/p>\n<p>D.C. to attend the largest biotechnology convention in the world in an<\/p>\n<p>effort to raise awareness for Omahas biotechnology programs.<\/p>\n<p>The group, which includes representatives from the academic, business<\/p>\n<p>and governmental sectors, will attend the BIO 2003 International Biotechnology<\/p>\n<p>Convention and Exhibition being held June 22-25 in Washington, D.C. About<\/p>\n<p>15,000 people from around the world are expected to attend this years<\/p>\n<p>convention.<\/p>\n<p>For the third consecutive year, the Nebraska contingent involves a partnership<\/p>\n<p>spearheaded by the UNMC and its technology transfer company, UNeMed. Other<\/p>\n<p>partners include the Greater Omaha Chamber of Commerce, Nebraska Department<\/p>\n<p>of Economic Development and the Omaha Public Power District. An area biotechnology<\/p>\n<p>company  Nature Technology Corp. of Lincoln  also will attend.<\/p>\n<p>Highlighting the UNMC display at this years conference will be a new<\/p>\n<p>product developed by a team of researchers in the UNMC College of Pharmacy.<\/p>\n<p>The product  a new form of creatine, a nutritional supplement taken by<\/p>\n<p>athletes to boost performance  is believed to have the potential to make<\/p>\n<p>a dramatic impact on the nutritional supplement industry.<\/p>\n<p>Were very excited about this technology, said Sam Augustine, Pharm.D.,<\/p>\n<p>associate professor in the UNMC College of Pharmacy and president of ProNutrient<\/p>\n<p>Technologies Inc., a company that was formed in 2001 to manufacture and<\/p>\n<p>distribute the supplement. We believe our form of creatine will prove<\/p>\n<p>to be more useful to the general public as well as the athletic community.<\/p>\n<p>Dr. Augustine said the ProNutrient form of creatine is more soluble<\/p>\n<p>in water and lipophilic (fat soluble) than creatine monohydrate, the most<\/p>\n<p>widely used salt form of creatine on the market. The monohydrate salt is<\/p>\n<p>poorly absorbed by the body and can cause gastrointestinal problems, he<\/p>\n<p>said.<\/p>\n<p>The changes we have made to creatine make it more bioavailable, meaning<\/p>\n<p>it is more readily absorbed by the body and presented to cells in a higher<\/p>\n<p>concentration, Dr. Augustine said. There also are minimal side effects,<\/p>\n<p>if any. In short, it is better absorbed and tolerated than the monohydrate<\/p>\n<p>form.<\/p>\n<p>Creatine is important biologically because it combines with phosphate<\/p>\n<p>and becomes a carrier for the energy system of the cell.&nbsp; There are<\/p>\n<p>other interesting observations with the use of this ester form that include<\/p>\n<p>more immediate muscle recovery from fatigue, and aches and pains. It should<\/p>\n<p>have a broad application that will benefit not only high-performance human<\/p>\n<p>and animal athletes but also the weekend warrior, and even aging pets.<\/p>\n<p>The technology used by ProNutrient is the result of three years of comprehensive<\/p>\n<p>research conducted at UNMC, Dr. Augustine said. Other College of Pharmacy<\/p>\n<p>faculty involved in the project included Donald Miller, Ph.D., Jonathan<\/p>\n<p>Vennerstrom, Ph.D., Jon Wagner, Pharm.D., and Dennis Robinson, Ph.D.<\/p>\n<p>Dr. Augustine said the ProNutrient form of creatine applies technology<\/p>\n<p>involving the concept of creating a pronutraceutical. The pharmaceutical<\/p>\n<p>industry uses these methods to create molecules that are metabolized by<\/p>\n<p>the body into active forms.<\/p>\n<p>Dr. Augustine recognized Drs. Miller and Vennerstrom for their work<\/p>\n<p>in making the creatine molecule an ester, thereby masking its acid portion<\/p>\n<p>with oxygen and carbon atoms.<\/p>\n<p>The product will be tested in a performance trial with subjects at Athletes<\/p>\n<p>Performance on the Arizona State University campus in the near future.<\/p>\n<p>Safety data for the ester is currently under review by the Food and Drug<\/p>\n<p>Administration.<\/p>\n<p>In 2002, ProNutrient obtained exclusive, worldwide rights from UNeMed<\/p>\n<p>for the creatine ester technology. That same year, the company received<\/p>\n<p>a $120,000 research grant from the Small Business Administration and the<\/p>\n<p>National Institutes of Health to identify and commercialize creatine ester<\/p>\n<p>products. Following trials, ProNutrient hopes to bring the product to market<\/p>\n<p>later this year.<\/p>\n<p>In addition to ProNutrient, several start-up companies and partnerships<\/p>\n<p>have been developed around UNMC technology. The newest of these include:<\/p>\n<p>&middot; Eleos, Inc. is developing low-cost, non-toxic, highly active<\/p>\n<p>therapeutics for major medical disorders.&nbsp; Its lead antisense oligonucleotide<\/p>\n<p>compound blocks the production of p53, a disease-promoting protein known<\/p>\n<p>to play a key role in cancer.<\/p>\n<p>&middot; Prommune, LLC is developing vaccines to drugs of addiction,<\/p>\n<p>agents of chemical and biological warfare and environmental toxins.&nbsp;<\/p>\n<p>The development of vaccines by Prommune employs a novel molecular adjuvant<\/p>\n<p>technology that was developed by UNMC faculty member Sam Sanderson, Ph.D.,<\/p>\n<p>associate professor, School of Allied Health Professions.<\/p>\n<p>We received more than 1,300 leads at the BIO 2002 Convention in Toronto,<\/p>\n<p>said Marsha Morien, administrator, advanced biomedical technologies. We<\/p>\n<p>are looking forward to a similar response this year. Its a wonderful opportunity<\/p>\n<p>to let others know that Omaha and UNMC are real players in the biotechnology<\/p>\n<p>field.<\/p>\n<p>This years theme for the Nebraska delegation will be BIOs Hot in<\/p>\n<p>Omaha.where UNMC is sizzlin with biotech opportunities. To attract more<\/p>\n<p>attention to the UNMC booth at the convention, Morien said UNMC will have<\/p>\n<p>a robotic dog named HotShot on display. Visitors to the booth can leave<\/p>\n<p>their business cards to be eligible for a drawing for HotShot at the end<\/p>\n<p>of the convention.<\/p>\n<p>Besides Morien and Dr. Augustine, other UNMC staff attending the convention<\/p>\n<p>include: Don Leuenberger, vice chancellor for business and finance; Tom<\/p>\n<p>McDonald, Ph.D., president and CEO, UNeMed; Sandy Goetzinger-Comer and<\/p>\n<p>Elizabeth Kumru, both public affairs; Kimberly Lamb, Ph.D., biotechnology<\/p>\n<p>marketing and management specialist, UNeMed; Leonard Agneta, J.D., director<\/p>\n<p>of the UNMC Intellectual Property Office; Rick Spellman, J.D., chairman<\/p>\n<p>of the board of directors, UNeMed; and Bob Bell, vice president for business<\/p>\n<p>and community development for UNeMed.<\/p>\n<\/div><\/div>","protected":false},"excerpt":{"rendered":"<p>In the scientific community, the invention of Gatorade in 1965 by a team of researchers at the University of Florida is a landmark event. By creating a drink that rapidly replaced lost fluids and helped prevent dehydration, the University of Florida opened the door to a windfall of royalties that brought millions of dollars back [&hellip;]<\/p>\n","protected":false},"author":79,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_relevanssi_hide_post":"","_relevanssi_hide_content":"","_relevanssi_pin_for_all":"","_relevanssi_pin_keywords":"","_relevanssi_unpin_keywords":"","_relevanssi_related_keywords":"","_relevanssi_related_include_ids":"","_relevanssi_related_exclude_ids":"","_relevanssi_related_no_append":"","_relevanssi_related_not_related":"","_relevanssi_related_posts":"","_relevanssi_noindex_reason":"","footnotes":""},"categories":[1],"tags":[],"class_list":["post-46963","post","type-post","status-publish","format-standard","hentry","category-uncategorized","department-press-release"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>UNMC to highlight new form of creatine at biotechnology convention in Washington, D.C.<\/title>\n<meta name=\"description\" content=\"In the scientific community, the invention of Gatorade in 1965 by a team of researchers at the University of Florida is a landmark event. 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