{"id":47055,"date":"2003-09-19T00:00:00","date_gmt":"2003-09-19T05:00:00","guid":{"rendered":"https:\/\/www.unmc.edu\/newsroom\/2003\/09\/19\/unmc-receives-almost-9-9-million-to-study-cell-signalingcancer\/"},"modified":"2022-08-29T10:43:32","modified_gmt":"2022-08-29T15:43:32","slug":"unmc-receives-almost-9-9-million-to-study-cell-signalingcancer","status":"publish","type":"post","link":"https:\/\/www.unmc.edu\/newsroom\/2003\/09\/19\/unmc-receives-almost-9-9-million-to-study-cell-signalingcancer\/","title":{"rendered":"UNMC receives almost $9.9 million to study cell signaling,\n\ncancer"},"content":{"rendered":"

The University of Nebraska Medical Center has received a five-year grant<\/p>\n

totaling almost $9.9 million from the National Institutes of Health (NIH)<\/p>\n

to further the understanding of cell signaling — the biochemical response<\/p>\n

of cells to their environment in relation to study a variety of cancers.<\/p>\n

The grant establishes an NIH-designated Nebraska Center for Cellular Signaling<\/p>\n

at UNMC, and is the second largest new grant in history received by UNMC.<\/p>\n

Funded by the Centers of Biomedical Research Excellence (CoBRE) program,<\/p>\n

an NIH-supported program, it also is the second CoBRE grant received in<\/p>\n

a week at UNMC. Last week, a grant for $10.6 million was received at UNMC<\/p>\n

for the NIH-designated Nebraska Center for Molecular Biology of Neurosensory<\/p>\n

Systems.<\/p>\n

Margaret Wheelock, Ph.D., professor of oral biology, UNMC College of<\/p>\n

Dentistry, is principal investigator of the latest grant and director of<\/p>\n

the new Nebraska Center for Cellular Signaling. The center will focus on<\/p>\n

the study of cell signaling, and will expand cellular signaling research<\/p>\n

of talented junior researchers to foster new research initiatives that<\/p>\n

ultimately will improve the health of Nebraskans and people around the<\/p>\n

world. Research projects will focus on relation to head and neck, prostate,<\/p>\n

colon, skin cancer and cancer in general.<\/p>\n

Im delighted that Dr. Wheelock and her associates have received this<\/p>\n

large grant award which in essence recognizes the excellence and importance<\/p>\n

of the science involved in the project and its potential for developing<\/p>\n

new, innovative scientists, said UNMC Chancellor Harold M. Maurer, M.D.<\/p>\n

These new scientists themselves will become independent researchers. What<\/p>\n

is equally impressive and unique is that this award is the second large<\/p>\n

COBRE grant from the NIH to UNMC in one month. I find our scientists truly<\/p>\n

amazing.<\/p>\n

Five research projects within the grant will be led by researchers from<\/p>\n

UNMC, the University of Nebraska-Lincoln and Creighton University. Each<\/p>\n

project involves the study of cellular signaling with a focus on its role<\/p>\n

in producing tumors. Cell signaling — the biochemical response of cells<\/p>\n

to their environment  — is a rapidly growing area of national research<\/p>\n

due to scientific and technological advances made in the last 10 years.<\/p>\n

This grant will allow us to bring together outstanding junior and senior<\/p>\n

faculty with similar interests, which will greatly enhance the science<\/p>\n

knowledge and opportunities for more collaboration. said Dr. Wheelock.<\/p>\n

It will increase the research profile of Nebraskas dental schools and<\/p>\n

develop junior researchers. We also will be working toward attracting more<\/p>\n

grants and researchers long after the COBRE grant concludes.<\/p>\n

Dr. Wheelock said the significant level of common themes among the five<\/p>\n

research projects strengthens the work, with the goal to further the understanding<\/p>\n

of the biological process of cancer.<\/p>\n

Normally, cells in the body signal to one another. During the cancer<\/p>\n

process, cell signaling goes awry. Were studying whats gone wrong in<\/p>\n

the signaling pathways when cells grow more rapidly and divide. If we can<\/p>\n

modify the information pathway in the cells, perhaps we can decrease the<\/p>\n

potential of the cancerous cell to spread, Dr. Wheelock said. Our clinicians<\/p>\n

have a lot of burning questions. If we could say this cell does this or<\/p>\n

that, the patient could be saved a lot of trauma. Getting this grant has<\/p>\n

been one of our goals. We have the right people. Thats exciting for the<\/p>\n

future.<\/p>\n

Dr. Wheelock has a long history of grant support from the National<\/p>\n

Institutes of Health, significant peer review experience and is committed<\/p>\n

to training and promoting junior investigators, said Tom Rosenquist, Ph.D.,<\/p>\n

UNMC vice-chancellor for research. She has identified highly qualified<\/p>\n

junior faculty members whose research focuses on cellular signaling and<\/p>\n

has also gathered an experienced group of mentors whose expertise covers<\/p>\n

a number of areas of cell signaling.<\/p>\n

Cell signaling is a burgeoning area of national research, Dr. Rosenquist<\/p>\n

said. This grant is extraordinarily valuable. This is where all the thinking<\/p>\n

outside the box pays off.<\/p>\n

This grant is representative of NIH’s confidence in the innovative<\/p>\n

work conducted by UNMC and its partners in science,” said U.S. Sen. Ben<\/p>\n

Nelson. “It is no surprise that UNMC has again been recognized as a preeminent<\/p>\n

institution by its peers.<\/p>\n

U.S. Sen. Chuck Hagel said the second NIH grant shows the outstanding<\/p>\n

work being done in UNMC research. The cutting edge work happening at UNMC<\/p>\n

will benefit greatly Nebraskans and the rest of our country.<\/p>\n

U.S. Rep. Lee Terry, said the state can be proud of the milestone. UNMC<\/p>\n

has established a national reputation as a leader in cutting-edge medical<\/p>\n

research,” Rep. Terry said. “This grant is further proof of that. The entire<\/p>\n

state of Nebraska can be proud. The fact that other local institutions<\/p>\n

— such as Creighton University — will take part in the research spurred<\/p>\n

by this grant spotlights the outstanding medical expertise in Nebraska.<\/p>\n

This is by far the single largest research grant the UNMC College of<\/p>\n

Dentistry has ever received, and is a major step in our research advancement,<\/p>\n

said John Reinhardt, D.D.S., dean of the UNMC College of Dentistry. With<\/p>\n

this financial support and the collaboration of senior and junior scientists<\/p>\n

and clinicians, we will establish a strong program of excellence for the<\/p>\n

study of oral cancer.<\/p>\n

The goal is to develop researchers and produce research that may lead<\/p>\n

to earlier diagnosis or new treatments for oral and other cancers. Dentists<\/p>\n

are often on the front line of diagnosis for cancers of the head, mouth, <\/p>\n

neck, and throat. Nearly 8,000 people in the U.S. die of oral and pharyngeal<\/p>\n

cancers each year.  Oral cancers are particularly aggressive; the<\/p>\n

overall 5-year survival rate is only 52 percent, worse than cancers of<\/p>\n

the breast, uterus, colon, and prostate, Dr. Reinhardt said.<\/p>\n

Project leaders of the centers first five grants are: James Wahl, Ph.D.<\/p>\n

and Sreenivas Koka, D.D.S., Ph.D., UNMC College of Dentistry Department<\/p>\n

of Oral Biology; Melanie Simpson, Ph.D., University of Nebraska-Lincoln;<\/p>\n

and Laura Hansen, Ph.D. and Bhakta Dey, Ph.D., Creighton School of Medicine<\/p>\n

Department of Biomedical Sciences.<\/p>\n

 <\/p>\n<\/div><\/div>","protected":false},"excerpt":{"rendered":"

The University of Nebraska Medical Center has received a five-year grant totaling almost $9.9 million from the National Institutes of Health (NIH) to further the understanding of cell signaling — the biochemical response of cells to their environment in relation to study a variety of cancers. The grant establishes an NIH-designated Nebraska Center for Cellular […]<\/p>\n","protected":false},"author":79,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_relevanssi_hide_post":"","_relevanssi_hide_content":"","_relevanssi_pin_for_all":"","_relevanssi_pin_keywords":"","_relevanssi_unpin_keywords":"","_relevanssi_related_keywords":"","_relevanssi_related_include_ids":"","_relevanssi_related_exclude_ids":"","_relevanssi_related_no_append":"","_relevanssi_related_not_related":"","_relevanssi_related_posts":"","_relevanssi_noindex_reason":"","footnotes":""},"categories":[1],"tags":[],"class_list":["post-47055","post","type-post","status-publish","format-standard","hentry","category-uncategorized","department-press-release"],"yoast_head":"\nUNMC receives almost $9.9 million to study cell signaling, cancer<\/title>\n<meta name=\"description\" content=\"The University of Nebraska Medical Center has received a 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