{"id":47316,"date":"2004-03-01T00:00:00","date_gmt":"2004-03-01T06:00:00","guid":{"rendered":"https:\/\/www.unmc.edu\/newsroom\/2004\/03\/01\/unmc-second-quarter-research-grants-total-9-7-million-2\/"},"modified":"2022-08-29T10:42:16","modified_gmt":"2022-08-29T15:42:16","slug":"unmc-second-quarter-research-grants-total-9-7-million-2","status":"publish","type":"post","link":"https:\/\/www.unmc.edu\/newsroom\/2004\/03\/01\/unmc-second-quarter-research-grants-total-9-7-million-2\/","title":{"rendered":"UNMC Second Quarter Research Grants Total $9.7 Million"},"content":{"rendered":"

The University of Nebraska Medical Center received $9.7 million in federal<\/p>\n

research grants during the second quarter of fiscal year 2003-2004. The<\/p>\n

second quarter included the months of October, November and December.<\/p>\n

As of February 2004, the universitys annual funding from the National<\/p>\n

Institutes of Health is $44.3 million, said Thomas Rosenquist, Ph.D.,<\/p>\n

vice chancellor for research. In the past two years, our NIH funding has<\/p>\n

increased by more than 40 percent, going from $30 million to $44.3 million.<\/p>\n

This is an exciting trend for UNMC since NIH funding is considered the<\/p>\n

gold standard for research funding. UNMC is fortunate to have a growing<\/p>\n

corps of investigators whose work attracts this prestigious funding. This<\/p>\n

puts us on pace to meet our goal of $50 million in annual NIH funding by<\/p>\n

the end of fiscal year 2004-2005.<\/p>\n

In addition, our record-breaking pace for extramural funding continues,<\/p>\n

following our $26 million first quarter for this fiscal year. The second<\/p>\n

quarter is similar to last years but we anticipate an excellent third<\/p>\n

quarter, based upon the large number of new research grant proposals that<\/p>\n

were submitted by our energized research force.<\/p>\n

Dr. Rosenquist said the new $77 million Durham Research Center is now<\/p>\n

open and many investigators have moved into the lower levels. The new facility<\/p>\n

will allow researchers to better collaborate on research projects and should<\/p>\n

greatly enhance UNMCs research efforts, he said.<\/p>\n

Some of UNMCs research highlights during the second quarter included:<\/p>\n

Kristine McVea, M.D., associate professor in the department of family<\/p>\n

medicine, received $485,550 to train teen peer group counselors for smoking<\/p>\n

cessation. Teen smoking is a significant cancer control problem that is<\/p>\n

currently not being addressed adequately, Dr. McVea said. Although 75 percent<\/p>\n

of high school smokers have tried to quit, almost all interventions designed<\/p>\n

to help teens break their habit have failed simply because teens do not<\/p>\n

seek help.<\/p>\n

In preliminary studies, peer counseling intervention has shown great<\/p>\n

promise. Project staff members give four hours of training to teen peer<\/p>\n

counselors who then deliver supportive, respectful smoking cessation messages<\/p>\n

to their friends at school.  The project goal is to do a randomized,<\/p>\n

controlled trial to test teen counseling effectiveness in 24 schools in<\/p>\n

eastern Nebraska and western Iowa over the next three years.<\/p>\n

Surinder Batra, Ph.D., professor, department of biochemistry and molecular<\/p>\n

biology, received $310,000 to study how the bodily absorption, distribution,<\/p>\n

metabolism and excretion of drugs with genetically-engineered antibodies<\/p>\n

are affected when the drugs are used to increase the penetration of cancer<\/p>\n

fighting antibodies into tumors. The use of surgery, radiation and chemotherapy<\/p>\n

either alone or in combination has met with only modest success for advanced<\/p>\n

cancer, Dr. Batra said. Radio immunotherapy (RAIT) is a smart way of<\/p>\n

delivering radiation to cancer cells and is independent of drug toxicity<\/p>\n

and\/or hormone resistance. But even targeted RAIT has met with limited<\/p>\n

success against advanced tumors. One form of therapy has been demonstrated<\/p>\n

to improve the efficiency of RAIT, but its use is limited by its high systemic<\/p>\n

toxicity. Dr. Batras study explores how to enhance vascular and tumor<\/p>\n

penetration while minimizing the harmful potential from toxicity.<\/p>\n

Bela Toth, DVM, professor at the Eppley Institute, received $220,000<\/p>\n

to study the use of extract from the CV mushroom in the treatment of gastrointestinal<\/p>\n

cancer a therapy already approved in Japan. Recently, hot water extracts<\/p>\n

from the CV mushroom have been used as nutritional supplements by cancer<\/p>\n

patients in the United States. Dr. Toths study will compare the bioactivity<\/p>\n

of the clinical preparation to the nutritional supplement to better understand<\/p>\n

the CV mushrooms ability to boost the immune system.  His project<\/p>\n

seeks to prove that the extract can enhance the immune system and lead<\/p>\n

to preventative and therapeutic activity in mice with colorectal cancer.<\/p>\n

John Davis, Ph.D., professor in the department of obstetrics and gynecology,<\/p>\n

and director of research and development for the Olson Center for Womens<\/p>\n

Health, received $121,074 to study how primary cells will provide information<\/p>\n

on the cellular events that control survival and proliferation of ovarian<\/p>\n

cells. This information is expected to translate into more effective treatments<\/p>\n

for enhancing reproductive potential in domestic farm animals. This research<\/p>\n

may also provide insight into abnormal conditions such as premature ovarian<\/p>\n

failure, ovarian disease and cell tumors of the ovary.<\/p>\n

Gloria Borgstahl, Ph.D., associate professor at the Eppley Institute,<\/p>\n

received $104,964 to develop a picture of what protein machines look like<\/p>\n

in order to understand how they work and how to fix them when they are<\/p>\n

broken. DNA the biological molecule that holds the genetic code encodes<\/p>\n

all the proteins used by the cell. When the DNA becomes damaged, the resulting<\/p>\n

proteins are abolished or become nonfunctional. Disease can result when<\/p>\n

proteins responsible for repairing damaged DNA are not working properly.<\/p>\n

The pathway of DNA repair studied in this project is thought to be of particular<\/p>\n

relevance to breast cancer.<\/p>\n<\/div><\/div>","protected":false},"excerpt":{"rendered":"

The University of Nebraska Medical Center received $9.7 million in federal research grants during the second quarter of fiscal year 2003-2004. The second quarter included the months of October, November and December. As of February 2004, the universitys annual funding from the National Institutes of Health is $44.3 million, said Thomas Rosenquist, Ph.D., vice chancellor […]<\/p>\n","protected":false},"author":79,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_relevanssi_hide_post":"","_relevanssi_hide_content":"","_relevanssi_pin_for_all":"","_relevanssi_pin_keywords":"","_relevanssi_unpin_keywords":"","_relevanssi_related_keywords":"","_relevanssi_related_include_ids":"","_relevanssi_related_exclude_ids":"","_relevanssi_related_no_append":"","_relevanssi_related_not_related":"","_relevanssi_related_posts":"","_relevanssi_noindex_reason":"","footnotes":""},"categories":[1],"tags":[],"class_list":["post-47316","post","type-post","status-publish","format-standard","hentry","category-uncategorized","department-press-release"],"yoast_head":"\nUNMC Second Quarter Research Grants Total $9.7 Million<\/title>\n<meta name=\"description\" content=\"The University of Nebraska Medical Center received $9.7 million in federal research grants during the second quarter of fiscal year 2003-2004. 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