{"id":47318,"date":"2003-12-15T00:00:00","date_gmt":"2003-12-15T06:00:00","guid":{"rendered":"https:\/\/www.unmc.edu\/newsroom\/2003\/12\/15\/innovative-projects-and-recruiting-lead-unmc-to-expandedgrant-funding\/"},"modified":"2022-08-29T10:43:03","modified_gmt":"2022-08-29T15:43:03","slug":"innovative-projects-and-recruiting-lead-unmc-to-expandedgrant-funding","status":"publish","type":"post","link":"https:\/\/www.unmc.edu\/newsroom\/2003\/12\/15\/innovative-projects-and-recruiting-lead-unmc-to-expandedgrant-funding\/","title":{"rendered":"Innovative projects and recruiting lead UNMC to expanded\n\ngrant funding"},"content":{"rendered":"

When the University of Nebraska Medical Center broke its record for<\/p>\n

total research grants in a single quarter by bringing in $26 million during<\/p>\n

July, August and September, it was a tribute to the universitys rise in<\/p>\n

innovative research projects and its ability to recruit top investigators.<\/p>\n

UNMC is fortunate that so many investigators are engaging in innovative<\/p>\n

research, said Thomas Rosenquist, Ph.D., UNMC vice chancellor for research.<\/p>\n

It is also important that the university has been able to hire so many<\/p>\n

of the best and brightest researchers in the country. During this first<\/p>\n

quarter, we had 40 research projects funded for $100,000 or more.<\/p>\n

David Bylund, Ph.D., UNMC professor of pharmacology, received a three-year,<\/p>\n

$497,000 grant funded by the National Institute of Mental Health (NIMH)<\/p>\n

to develop laboratory animal models for testing antidepressants designed<\/p>\n

for children and adolescents.<\/p>\n

There are no established juvenile rodent animal models of clinical<\/p>\n

depression, Dr. Bylund said. We have reasonable rodent animal models<\/p>\n

for adults that predict more than 90 percent of how well drugs work in<\/p>\n

adult humans, but no one to this point has looked at models in the young<\/p>\n

animal to see what drugs might be effective in children and adolescents.<\/p>\n

An important difference between clinical depression in children and adolescents,<\/p>\n

as compared to adults, is the response to anti-depressant drugs.<\/p>\n

One of UNMCs newest researchers is Christine Eischen, Ph.D., assistant<\/p>\n

professor, Eppley Cancer Institute. She received a grant for $1.47 million<\/p>\n

over five years from the National Institutes of Health.<\/p>\n

The focus of my research is to identify and characterize specific genes<\/p>\n

that regulate lymphoma development, Dr. Eischen said. We utilize mouse<\/p>\n

models that mimic important aspects of human lymphoma and biochemical and<\/p>\n

molecular approaches to evaluate genes of interest.  Determining the<\/p>\n

function of the identified genes in a living organism is critical to understand<\/p>\n

the physiological role that specific genes have in normal cell growth and<\/p>\n

survival and how these genes are then altered in cancer.<\/p>\n

The goal of our research is to increase understanding of how lymphoma<\/p>\n

develops, which should lead to improved therapeutics for the treatment<\/p>\n

of lymphoma.<\/p>\n

 On the other hand, Irving Zucker, Ph.D, Theodore F. Hubbard Professor<\/p>\n

of Cardiovascular Research and chairman, department of physiology and biophysics,<\/p>\n

is one of the universitys most senior researchers.<\/p>\n

He received nearly $2 million to study chronic heart failure.<\/p>\n

Heart failure is a disorder that is growing in epidemic proportions<\/p>\n

in the United States, Dr. Zucker said. This is due, in part, to an aging<\/p>\n

population and to medicine’s ability to enhance survival from acute events<\/p>\n

such as heart attacks and rhythm disturbances. Our project is designed<\/p>\n

to study the relationships between the nervous system and the circulatory<\/p>\n

system in animal models of chronic heart failure. Because the nervous system<\/p>\n

is responsible for changes in heart rate and in the force of the contraction<\/p>\n

of the heart and blood vessels, over activity of this portion of the nervous<\/p>\n

system contributes to a worsening of the heart failure state.<\/p>\n

Our studies will elucidate the cellular and molecular mechanisms that<\/p>\n

contribute to the increased nervous activity. We will investigate these<\/p>\n

mechanisms in the brain and in the peripheral circulation. Finally, we<\/p>\n

will determine the role of exercise training on alterations in these mechanisms<\/p>\n

and on the changes in heart function that exercise training effects in<\/p>\n

our models of heart failure. These studies will lead to an enhanced understanding<\/p>\n

of the mechanisms responsible for the continual deterioration of the cardiovascular<\/p>\n

system in chronic heart failure patients.<\/p>\n

Keith Mueller, Ph.D., professor, department of preventive and society<\/p>\n

medicine, received $1.2 million to establish a center for rural health<\/p>\n

policy.<\/p>\n

The RUPRI (Rural Policy Research Institute) Center for Rural Health<\/p>\n

Policy Analysis conducts several small scale studies designed to help shape<\/p>\n

public policy, Dr. Mueller said.<\/p>\n

Projects funded for the current year include:  examining reasons<\/p>\n

for increases in health care costs in rural areas; developing a methodology<\/p>\n

for selecting rural communities to participate in a special project to<\/p>\n

monitor changes in health care delivery and other services in those communities;<\/p>\n

simulating the effects of changes in Medicare payment on physician practice<\/p>\n

revenues; and assessing the development of Medicare preferred provider<\/p>\n

organizations in rural areas.<\/p>\n

The center performed an analysis of the differences in Medicare payments<\/p>\n

to physicians in rural areas compared to physicians in urban areas, and<\/p>\n

the data was helpful in determining an acceptable payment for physicians<\/p>\n

and included in the Medicare prescription drug legislation. The center<\/p>\n

also performed an analysis of health insurance plans participating in the<\/p>\n

Federal Employment Health Benefits Plan.<\/p>\n<\/div><\/div>","protected":false},"excerpt":{"rendered":"

When the University of Nebraska Medical Center broke its record for total research grants in a single quarter by bringing in $26 million during July, August and September, it was a tribute to the universitys rise in innovative research projects and its ability to recruit top investigators. UNMC is fortunate that so many investigators are […]<\/p>\n","protected":false},"author":79,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_relevanssi_hide_post":"","_relevanssi_hide_content":"","_relevanssi_pin_for_all":"","_relevanssi_pin_keywords":"","_relevanssi_unpin_keywords":"","_relevanssi_related_keywords":"","_relevanssi_related_include_ids":"","_relevanssi_related_exclude_ids":"","_relevanssi_related_no_append":"","_relevanssi_related_not_related":"","_relevanssi_related_posts":"","_relevanssi_noindex_reason":"","footnotes":""},"categories":[1],"tags":[],"class_list":["post-47318","post","type-post","status-publish","format-standard","hentry","category-uncategorized","department-press-release"],"yoast_head":"\nInnovative projects and recruiting lead UNMC to expanded grant funding<\/title>\n<meta name=\"description\" content=\"When the University of Nebraska Medical Center broke its record for 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