{"id":47415,"date":"1999-03-10T00:00:00","date_gmt":"1999-03-10T06:00:00","guid":{"rendered":"https:\/\/www.unmc.edu\/newsroom\/1999\/03\/10\/national-cancer-institute-breast-cancer-expert-nameddirector-of-unmc-eppley-cancer-center\/"},"modified":"2022-08-29T10:58:53","modified_gmt":"2022-08-29T15:58:53","slug":"national-cancer-institute-breast-cancer-expert-nameddirector-of-unmc-eppley-cancer-center","status":"publish","type":"post","link":"https:\/\/www.unmc.edu\/newsroom\/1999\/03\/10\/national-cancer-institute-breast-cancer-expert-nameddirector-of-unmc-eppley-cancer-center\/","title":{"rendered":"National Cancer Institute Breast Cancer Expert Named\n\nDirector of UNMC Eppley Cancer Center"},"content":{"rendered":"<div class=\"panel body-content\"><div class=\"panel__container\"><p><\/FONT><\/B><\/p>\n<p><P>Kenneth H. Cowan, M.D., Ph.D., a leading breast cancer expert at the<\/p>\n<p>National Cancer Institute in Bethesda, Md., has been named director of<\/p>\n<p>the Eppley Institute for Research in Cancer &amp; Allied Diseases and the<\/p>\n<p>UNMC Eppley Cancer Center. The appointment is subject to the approval of<\/p>\n<p>the University of Nebraska Board of Regents at its next meeting.<\/p>\n<p><P>Dr. Cowan, 51, will assume his new post on Aug. 1. Since completing<\/p>\n<p>his residency training at Texas Southwestern Affiliated Hospitals in Dallas,<\/p>\n<p>Dr. Cowan has spent his entire 21-year career at the NCI. Since 1988, he<\/p>\n<p>has served as chief of the Medical Breast Cancer Section, Medicine Branch,<\/p>\n<p>and serves as a captain in the Public Health Service, which includes physicians<\/p>\n<p>in the National Institutes of Health. In his NCI position, he was responsible<\/p>\n<p>for overseeing a $1 million budget and a 21-person staff. His breast cancer<\/p>\n<p>group included 12 laboratory researchers and a clinical staff of six performing<\/p>\n<p>trials in patients with breast cancer.<\/p>\n<p><P>&#8220;Dr. Cowan is a marvelous recruit for our Medical Center,&#8221; said Harold<\/p>\n<p>M. Maurer, M.D., University of Nebraska Medical Center chancellor. &#8220;He<\/p>\n<p>fits perfectly into our aim and vision of becoming a world class academic<\/p>\n<p>health sciences center.<\/p>\n<p><P>&#8220;We recently hired an outstanding molecular geneticist in Dr. Richard<\/p>\n<p>Finnell. Now, with Dr. Cowan, we are getting one of the world&#8217;s leading<\/p>\n<p>experts in the use of gene therapy for breast cancer. We&#8217;re thrilled to<\/p>\n<p>get somebody of his caliber. His credentials are outstanding &#8212; he comes<\/p>\n<p>from the world&#8217;s leading cancer research institute and is right at the<\/p>\n<p>top of his game.&#8221;<\/p>\n<p><P>Dr. Cowan said he is excited about his new position. &#8220;I&#8217;ve been recruited<\/p>\n<p>by a number of cancer centers in the past couple years. The Nebraska situation<\/p>\n<p>is unique. It includes an excellent mix of basic scientists and clinical<\/p>\n<p>scientists. All the components are in place for basic ideas in the laboratory<\/p>\n<p>to be translated into therapeutic trials.<\/p>\n<p><P>&#8220;Nebraska has always had a strong program in studying the origins of<\/p>\n<p>cancer. Now they have developed outstanding clinical programs in cancer<\/p>\n<p>therapy, including bone marrow transplantation. We hope to complement these<\/p>\n<p>clinical programs with new basic research programs in cancer genetics,<\/p>\n<p>cancer cell biology and cancer immunology. We hope to create an environment<\/p>\n<p>in which exciting observations made in the lab can be rapidly brought to<\/p>\n<p>the patient&#8217;s bedside in the form of new therapies to treat and prevent<\/p>\n<p>cancer. The more we understand about the molecular basis of cancer the<\/p>\n<p>better this knowledge can be used to more effectively treat and prevent<\/p>\n<p>cancer.<\/p>\n<p><P>&#8220;It&#8217;s an exciting time. The cancer center is already strong, and the<\/p>\n<p>university is making a strong commitment to developing an even stronger<\/p>\n<p>program. We want to become a world class comprehensive cancer center with<\/p>\n<p>outstanding screening and prevention programs as well as cancer treatment<\/p>\n<p>programs that can serve the entire region.&#8221;<\/p>\n<p><P>Dr. Cowan&#8217;s breast cancer research focused on the mechanisms of drug<\/p>\n<p>resistance, the biology of breast cancer and gene therapy. He has orchestrated<\/p>\n<p>several clinical trials seeking new therapeutic applications for breast<\/p>\n<p>cancer. These clinical trials have focused on gene therapy and trying to<\/p>\n<p>identify new agents in the treatment of the disease.<\/p>\n<p><P>A New York City native, Dr. Cowan earned his undergraduate degree at<\/p>\n<p>the University of Rochester in Rochester, N.Y. and his medical and doctorate<\/p>\n<p>degrees from Case Western Reserve University in Cleveland.<\/p>\n<p><P>Among his awards, Dr. Cowan received the Public Health Service Outstanding<\/p>\n<p>Service Medal in 1991. He has authored more than 200 papers for scientific<\/p>\n<p>journals and has been an invited guest lecturer for at least a dozen scientific<\/p>\n<p>conferences in the past two years. He will make a major presentation on<\/p>\n<p>his gene therapy breast cancer clinical trial at the American Society of<\/p>\n<p>Clinical Oncology meeting in Atlanta in May.<\/p>\n<p><P>Dr. Cowan said he expects to bring at least one of his clinical trials<\/p>\n<p>to Omaha. This trial involves transferring drug-resistance genes into bone<\/p>\n<p>marrow cells prior to giving these cells back to breast cancer patients<\/p>\n<p>undergoing a bone marrow transplant. The hope is that the drug-resistance<\/p>\n<p>genes will allow patients to receive higher doses of chemotherapy with<\/p>\n<p>less toxicity.<\/p>\n<p><P>He also has been working on taking genes that can inhibit the growth<\/p>\n<p>of breast and ovarian cancer cells,&nbsp; re-engineering these genes, and<\/p>\n<p>then injecting them back into the tumor as a way of getting these special<\/p>\n<p>genes into the tumor cells. This work has<\/p>\n<p><BR>been done on animals to date, but hopefully can be extended to humans<\/p>\n<p>in clinical trials in the near future.<\/p>\n<p><P>During the recruitment process, Dr. Cowan made four trips back to Nebraska<\/p>\n<p>and met with many people. He had special words of appreciation for the<\/p>\n<p>Friends of the UNMC Eppley Cancer Center, a community-based organization<\/p>\n<p>committed to raising funds for cancer research. &#8220;The Friends were very<\/p>\n<p>active in the recruiting process. They were outstanding. They really impressed<\/p>\n<p>me with their commitment to the cancer center, and they made it much easier<\/p>\n<p>for me to want to move to Omaha.&#8221;<\/p>\n<p><P>Dr. Cowan said the NCI and NIH are both expected to increase their budgets<\/p>\n<p>by 15 percent this year and continue to increase their budgets over the<\/p>\n<p>next five years. This money will be used to fund extramural research<\/p>\n<p><BR>at universities and cancer centers.<\/p>\n<p><P>&#8220;It&#8217;s an opportune time to expand cancer research programs,&#8221; he said.<\/p>\n<p>&#8220;If UNMC can make a commitment to develop additional research, the opportunity<\/p>\n<p>to get NIH funding is going to be much greater.&#8221; He cited the four levels<\/p>\n<p>of research space in The Lied Transplant Center as indicative of UNMC&#8217;s<\/p>\n<p>commitment to doing more research.<\/p>\n<p><P>With the additional research funds that should be available, Dr. Cowan<\/p>\n<p>said he hopes to double cancer center research over the next 5 to 10 years.<\/p>\n<p>UNMC has committed to hiring 10 new faculty members in addition to the<\/p>\n<p>three or four researchers expected to come with Dr. Cowan from the NCI.<\/p>\n<p><P>The Eppley Institute was founded in 1961. Dr. Cowan will be the sixth<\/p>\n<p>director in the institute&#8217;s 38-year history. He replaces Raymond W. Ruddon,<\/p>\n<p>Jr., M.D., Ph.D., who served as director of the Eppley Institute and the<\/p>\n<p>UNMC Eppley Cancer Center from 1989 to 1997.&nbsp; Dr. Ruddon left to become<\/p>\n<p>director of the Corporate Office of Science and Technology with Johnson<\/p>\n<p>&amp; Johnson Corp. in New Brunswick, N.J.<\/p>\n<p><P>Barry Gold, Ph.D., professor in the Eppley Institute, has served as<\/p>\n<p>interim director of the Eppley Institute since Dr. Ruddon&#8217;s departure.<\/p>\n<p>Margaret Tempero, M.D., deputy director of the UNMC Eppley Cancer Center,<\/p>\n<p>has served as interim director of the cancer center.<\/p>\n<p><P>The UNMC Eppley Cancer Center is a NCI designated cancer center &#8212; a<\/p>\n<p>distinction held by only 55 centers in the country. Of the $34.3 million<\/p>\n<p>in competitive, external research grants and contracts awarded to UNMC<\/p>\n<p>in 1997-98, cancer-related research accounted for about one-half of that<\/p>\n<p>amount.<\/p>\n<p><P>The UNMC Eppley Cancer Center was created in 1993 by the University<\/p>\n<p>of Nebraska Board of Regents in a move that united cancer researchers throughout<\/p>\n<p>the UNMC campus into a larger single entity. It marked a major first step<\/p>\n<p>toward Eppley&#8217;s quest to eventually become a comprehensive cancer center,<\/p>\n<p>the most prestigious designation awarded by the NCI.<\/p>\n<p><P>Dr. Maurer recognized the work of the search committee headed by James<\/p>\n<p>Armitage, M.D., professor and chairman of the UNMC internal medicine department.&nbsp;<\/p>\n<p>The search committee reviewed the applications of about 20 leading cancer<\/p>\n<p>experts and conducted interviews with a half-dozen individuals. &#8220;The search<\/p>\n<p>committee did a terrific job,&#8221; Dr. Maurer said. &#8220;This was an extremely<\/p>\n<p>important position for our campus.&nbsp; I couldn&#8217;t be more pleased with<\/p>\n<p>our final selection.&#8221;<\/p>\n<p><P>Dr. Cowan&#8217;s wife, Alison Freifeld, is an infectious disease specialist<\/p>\n<p>at the NCI who works with infection problems encountered by cancer patients.<\/p>\n<p>The couple has two daughters B Sara, 12, and Eliza, 9.<\/p>\n<\/div><\/div>","protected":false},"excerpt":{"rendered":"<p>Kenneth H. Cowan, M.D., Ph.D., a leading breast cancer expert at the National Cancer Institute in Bethesda, Md., has been named director of the Eppley Institute for Research in Cancer &amp; Allied Diseases and the UNMC Eppley Cancer Center. The appointment is subject to the approval of the University of Nebraska Board of Regents at [&hellip;]<\/p>\n","protected":false},"author":79,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_relevanssi_hide_post":"","_relevanssi_hide_content":"","_relevanssi_pin_for_all":"","_relevanssi_pin_keywords":"","_relevanssi_unpin_keywords":"","_relevanssi_related_keywords":"","_relevanssi_related_include_ids":"","_relevanssi_related_exclude_ids":"","_relevanssi_related_no_append":"","_relevanssi_related_not_related":"","_relevanssi_related_posts":"","_relevanssi_noindex_reason":"","footnotes":""},"categories":[1],"tags":[],"class_list":["post-47415","post","type-post","status-publish","format-standard","hentry","category-uncategorized","department-press-release"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>National Cancer Institute Breast Cancer Expert Named Director of UNMC Eppley Cancer Center<\/title>\n<meta name=\"description\" content=\"Kenneth H. 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