{"id":47548,"date":"2000-08-29T00:00:00","date_gmt":"2000-08-29T05:00:00","guid":{"rendered":"https:\/\/www.unmc.edu\/newsroom\/2000\/08\/29\/unmc-researchers-involved-in-studying-implantable-devicethat-may-become-the-first-new-type-of-treatment-for-depression-in-50-years\/"},"modified":"2022-08-29T10:54:41","modified_gmt":"2022-08-29T15:54:41","slug":"unmc-researchers-involved-in-studying-implantable-devicethat-may-become-the-first-new-type-of-treatment-for-depression-in-50-years","status":"publish","type":"post","link":"https:\/\/www.unmc.edu\/newsroom\/2000\/08\/29\/unmc-researchers-involved-in-studying-implantable-devicethat-may-become-the-first-new-type-of-treatment-for-depression-in-50-years\/","title":{"rendered":"UNMC Researchers Involved in Studying Implantable Device\n\nThat May Become the First New Type of Treatment for Depression in 50 Years"},"content":{"rendered":"

Researchers at the University of Nebraska Medical Center Department<\/p>\n

of Psychiatry are involved in a nationwide study that could become the<\/p>\n

first new treatment for depression in 50 years. Out of more than 100 sites<\/p>\n

that applied to participate in the study, UNMC was one of 20 centers selected<\/p>\n

to test the safety and effectiveness of an implantable device.<\/p>\n

UNMC has received a $275,000 grant from Cyberonics, Inc., to conduct<\/p>\n

a 12-week study that will test the companys NeuroCybernetic Prosthesis<\/p>\n

system, an implantable device similar to a cardiac pacemaker. The device<\/p>\n

is a stopwatch-sized generator implanted in the chest with a nerve stimulation<\/p>\n

electrode attached to the vagus nerve in the neck. It delivers preprogrammable,<\/p>\n

intermittent electrical pulses 24 hours a day.<\/p>\n

The device will be studied for its effectiveness in people with moderate<\/p>\n

to severe depression who have not responded to other treatments. Current<\/p>\n

treatments options for depression include anti-depressant drugs, psychotherapy,<\/p>\n

and electroconvulsive therapy.<\/p>\n

UNMC is seeking from 10 to 30 patients age 19 to 65 with recurring,<\/p>\n

severe to moderate depression who have failed to respond to conventional<\/p>\n

treatment. About 200 patients will be enrolled nationwide.<\/p>\n

This may give people with severe depression another option, said William<\/p>\n

Burke, M.D., professor and director of the UNMC Psychopharmacology Research<\/p>\n

Center. We have good therapy for probably 90 percent of people with depression<\/p>\n

but there have been a group of about 10 percent who have more persistent<\/p>\n

depression that does not respond to treatment.<\/p>\n

We are encouraged by the results from the pilot study. Forty percent<\/p>\n

of the 30 patients in an initial study met criteria for having recovered<\/p>\n

from their depression. That is pretty amazing given the average length<\/p>\n

of time that those persons had been depressed was more than 10 years. Rates<\/p>\n

of relapse have also been low in those who recovered, which is also impressive<\/p>\n

given that relapse for this type of depression is not unusual.<\/p>\n

He said no one knows for sure how the device helps treat depression.<\/p>\n

The theory is that the vagus nerve, which sends signals up to the part<\/p>\n

of the brain that controls sleep, appetite and energy, may work like many<\/p>\n

of the drugs we use as antidepressants. This device may deliver a more<\/p>\n

direct electrical stimulation to those parts of the brain that weve been<\/p>\n

trying to stimulate with medicine.<\/p>\n

The device, not yet approved for treating depression in the U.S., was<\/p>\n

approved in 1994 in Europe and 1997 in the U.S. for the treatment of epilepsy<\/p>\n

and has been used over 10,000 patients with epilepsy.<\/p>\n

Chosen to participate in the study to date are: UNMC, the University<\/p>\n

of Minnesota; University of Miami, Saint Louis University; Medical University<\/p>\n

of South Carolina in Charleston; Baylor College of Medicine in Houston;<\/p>\n

Stanford University, Brown University\/Butler Hospital, Via Christi Psychiatric<\/p>\n

Research Institute in Kansas City; SUNY Upstate Medical University at Syracuse<\/p>\n

and Emory University in Atlanta.<\/p>\n

The reason the device is even being tested in depression is that when<\/p>\n

the device has been used in epilepsy, neurologists reported that it was<\/p>\n

having positive effect on peoples mood and their sense of well-being even <\/p>\n

if it didnt reduce the number of seizures.<\/p>\n

Patients will be screened for eligibility in the study. Patients accepted<\/p>\n

into the study will have the device implanted free by UNMC surgeons, Drs.<\/p>\n

Dan and Bill Lydiatt, followed by an estimated two-week recovery period.<\/p>\n

Implanting the device typically takes one to two hours in an outpatient<\/p>\n

basis. During the 12-week controlled study following surgical recovery,<\/p>\n

half of the patients devices will be turned on while the other half will<\/p>\n

be turned off.  During that time patients will remain on whatever<\/p>\n

medications they had been taking.<\/p>\n

Dr. Burke said most people in the study wont be aware the device is<\/p>\n

on. After the 12-week controlled study, all devices will be tuned on and<\/p>\n

treatment will continue with periodic visits. There are no costs to persons<\/p>\n

participating in the study.<\/p>\n

Depression is one of the most painful human conditions, Dr. Burke<\/p>\n

said. Depression causes low mood, lack of interest, makes it very hard<\/p>\n

to get things done, and can deprive people of any sense of pleasure. They<\/p>\n

may have problems sleeping, poor appetite, low energy, and may walk around<\/p>\n

in a fog.  They may think life isnt worth living and consider suicide<\/p>\n

as a way out. Its a horrible condition to live with.<\/p>\n

It is telling that the primary concern of the people weve talked to<\/p>\n

so far has been whether this will help their depression my expectation<\/p>\n

was that they would be far more focused on the surgical procedure, Dr.<\/p>\n

Burke said. Theyve been depressed for so long and feel so lousy that<\/p>\n

their focus is simply finding something to help them.<\/p>\n

For more information about the study, call UNMC at (402) 559-5056. Information<\/p>\n

about the device and study also can be found at www.cyberonics.com.<\/p>\n

Cyberonics, Inc. was founded in 1987 to design, develop and market medical<\/p>\n

devices for the treatment of epilepsy and other debilitating disorders<\/p>\n

using a unique therapy, vagus nerve stimulation. The company’s initial<\/p>\n

target market is epilepsy, the world’s second most prevalent neurological<\/p>\n

disorder, which is characterized by recurrent seizures.<\/p>\n

UNMC is the only public academic health science center in the state.<\/p>\n

Its educational programs are responsible for training more health professionals<\/p>\n

practicing in Nebraska than any other institution. Through its commitment<\/p>\n

to research, education, outreach and patient care, UNMC has established<\/p>\n

itself as one of the country’s leading centers for research in cancer,<\/p>\n

genetics, cardiovascular diseases, neurodegenerative diseases and arthritis.<\/p>\n

During the past year, UNMCs research funding increased by 31 percent and<\/p>\n

now exceeds $40 million, including more than $25 million in federal funding<\/p>\n

from such sources as the National Institutes of Health, the National Science<\/p>\n

Foundation, Department of Defense and Veterans Administration.<\/p>\n

 <\/p>\n<\/div><\/div>","protected":false},"excerpt":{"rendered":"

Researchers at the University of Nebraska Medical Center Department of Psychiatry are involved in a nationwide study that could become the first new treatment for depression in 50 years. Out of more than 100 sites that applied to participate in the study, UNMC was one of 20 centers selected to test the safety and effectiveness […]<\/p>\n","protected":false},"author":79,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_relevanssi_hide_post":"","_relevanssi_hide_content":"","_relevanssi_pin_for_all":"","_relevanssi_pin_keywords":"","_relevanssi_unpin_keywords":"","_relevanssi_related_keywords":"","_relevanssi_related_include_ids":"","_relevanssi_related_exclude_ids":"","_relevanssi_related_no_append":"","_relevanssi_related_not_related":"","_relevanssi_related_posts":"","_relevanssi_noindex_reason":"","footnotes":""},"categories":[1],"tags":[],"class_list":["post-47548","post","type-post","status-publish","format-standard","hentry","category-uncategorized","department-press-release"],"yoast_head":"\nUNMC Researchers Involved in Studying Implantable Device That May Become the First New Type of 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