{"id":47643,"date":"2001-08-10T00:00:00","date_gmt":"2001-08-10T05:00:00","guid":{"rendered":"https:\/\/www.unmc.edu\/newsroom\/2001\/08\/10\/unmc-college-of-dentistry-researchers-receive-morethan-2-million-to-study-effect-of-drug-on-preventing-treating-oral-boneloss\/"},"modified":"2022-08-29T10:51:51","modified_gmt":"2022-08-29T15:51:51","slug":"unmc-college-of-dentistry-researchers-receive-morethan-2-million-to-study-effect-of-drug-on-preventing-treating-oral-boneloss","status":"publish","type":"post","link":"https:\/\/www.unmc.edu\/newsroom\/2001\/08\/10\/unmc-college-of-dentistry-researchers-receive-morethan-2-million-to-study-effect-of-drug-on-preventing-treating-oral-boneloss\/","title":{"rendered":"UNMC College of Dentistry Researchers Receive More\n\nThan $2 Million to Study Effect of Drug on Preventing, Treating Oral Bone\n\nLoss"},"content":{"rendered":"

University of Nebraska Medical Center College of Dentistry researcher<\/p>\n

and dentist, Jeffrey B. Payne, D.D.S., has seen many elderly women patients<\/p>\n

suffer the loss of teeth because of periodontitis a disease that causes<\/p>\n

destruction of bone and gums, the supporting structures of the teeth. Periodontitis<\/p>\n

is the number one cause of tooth loss in men and women in the United States.<\/p>\n

With the help of a five-year, $2.09 million clinical trial grant from<\/p>\n

the National Institutes of Health, National Institute of Dental and Craniofacial<\/p>\n

Research, Dr. Payne and other researchers will evaluate the effectiveness<\/p>\n

of Dr. Payne and other researchers will evaluate the effectiveness of a<\/p>\n

drug called Periostat in reducing oral bone loss and improving bone density<\/p>\n

in the hip and spine of women.  Researchers know periodontitis results<\/p>\n

in collagen being broken down, ultimately destroying bone.<\/p>\n

Women are concerned about losing teeth, said Dr. Payne, UNMC assistant<\/p>\n

dean for research and F. Gene and Rosemary Dixon Endowed Chair in Dentistry.<\/p>\n

They are extremely health conscious. In general, if patients lose teeth,<\/p>\n

they want to replace them because of lost function and for aesthetic reasons.<\/p>\n

Once a tooth is lost, other teeth start drifting. This compromises chewing<\/p>\n

function and a patients quality of life.<\/p>\n

Periodontitis, which results in the loss of bone supporting teeth in<\/p>\n

the jaws, affects about 36 percent of U.S. adults, Dr. Payne said.<\/p>\n

Periostatâ was approved by the FDA in September 1998 and is the<\/p>\n

first and only oral drug approved as an additional treatment for periodontitis. <\/p>\n

The drug helps prevent the breakdown of collagen, a major structural protein<\/p>\n

of the body that is found in bone, skin, gum tissues, ligaments and cartilage.<\/p>\n

Before the drug was approved, periodontitis was treated primarily through<\/p>\n

teeth cleaning and surgery.<\/p>\n

The critical destructive phase in periodontitis is the destruction<\/p>\n

of collagen. If you can inhibit that process, then you can inhibit bone<\/p>\n

loss and perhaps even enhance bone gain, said Dr. Payne, principal investigator<\/p>\n

for the grant.  If our hypothesis proves correct, Periostatâ<\/p>\n

could be used to prevent the loss of bone and gum support in the mouth,<\/p>\n

thus reducing tooth loss, said Dr. Payne, principal investigator of the<\/p>\n

study.<\/p>\n

Researchers at UNMC and the State University of New York at Stony Brook<\/p>\n

School of Dental Medicine will test the effectiveness of Periostatâ<\/p>\n

in 120 post-menopausal women, ages 45 to 70 years old, who have periodontitis<\/p>\n

and osteopenia. Osteopenia is reduced bone mass in the body and represents<\/p>\n

an early stage of osteoporosis.<\/p>\n

Osteoporosis, or porous bone, is a disease characterized by low bone<\/p>\n

mass and structural deterioration of bone tissue, leading to bone fragility<\/p>\n

and an increased susceptibility to fractures of the hip, spine, and wrist.<\/p>\n

It is a major public health threat for more than 28 million Americans,<\/p>\n

80 percent of whom are women. In the U.S. today, 10 million individuals<\/p>\n

already have osteoporosis and 18 million more have low bone mass, placing<\/p>\n

them at increased risk for the disease.<\/p>\n

In the double-blind study, which means neither researchers nor the participants<\/p>\n

will know who received the drug and who received the placebo, women eligible<\/p>\n

for the study will receive free screenings, tests, Periostatâ and<\/p>\n

a daily dose of 1,200 milligrams of calcium and 400 international units<\/p>\n

of vitamin D. Tests, including intraoral X-rays and dual energy X-ray absorptiometry<\/p>\n

(DEXA) scans, will be given at the beginning of the study and at one and<\/p>\n

two years. A DEXA scan is a fast, simple X-ray that evaluates the density<\/p>\n

of the hip and spine to confirm osteopenia or osteoporosis.  Art Weaver,<\/p>\n

M.D., of the Arthritis Center of Nebraska, who also is a UNMC clinical<\/p>\n

professor of internal medicine, will work with UNMC College of Dentistry<\/p>\n

researchers on DEXA data generated from this study.<\/p>\n

Women will continue to see their periodontists during the study.<\/p>\n

In addition to oral bone loss, researchers will also look at the drugs<\/p>\n

potential to treat osteopenia.<\/p>\n

Dr. Payne said, If you can treat or inhibit oral bone loss, it would<\/p>\n

be beneficial at the same time to reduce systemic bone loss. Another important<\/p>\n

issue in studying oral bone loss is the compelling scientific evidence<\/p>\n

emerging about the relationship between the health of the mouth and the<\/p>\n

systemic health of the body.<\/p>\n

Last year, the United States Surgeon General, in its first report ever<\/p>\n

on oral health, addressed the importance of oral health in maintaining<\/p>\n

systemic, or overall, health.<\/p>\n

There is more scientific evidence emerging that tells us if a person<\/p>\n

doesnt maintain a healthy oral environment, that could place them at risk<\/p>\n

for other systemic diseases, Dr. Payne said.  We also know that<\/p>\n

systemic diseases such as uncontrolled diabetes and osteoporosis place<\/p>\n

individuals at greater risk for tooth loss.<\/p>\n

Our hypothesis is that this drug will reduce oral bone loss and enhance<\/p>\n

bone gain, but we also want to know if it will inhibit bone loss in the<\/p>\n

body — specifically in the hip and lumbar spine of post-menopausal women.<\/p>\n

If this drug has a positive effect on the hip and spine, it will lead to<\/p>\n

another larger study to look at this systemic outcome.  Periostatâ<\/p>\n

could potentially be a very inexpensive, safe therapy for osteopenia and<\/p>\n

osteoporosis.<\/p>\n

The outcomes of this study could very well lead to a lot of new areas <\/p>\n

of research, which was what the NIH review team was very excited about.<\/p>\n

 For more information about enrolling in the study, call Julie<\/p>\n

Layton, (402) 472-9852. The UNMC College of Dentistry is located in Lincoln.<\/p>\n<\/div><\/div>","protected":false},"excerpt":{"rendered":"

University of Nebraska Medical Center College of Dentistry researcher and dentist, Jeffrey B. Payne, D.D.S., has seen many elderly women patients suffer the loss of teeth because of periodontitis a disease that causes destruction of bone and gums, the supporting structures of the teeth. Periodontitis is the number one cause of tooth loss in men […]<\/p>\n","protected":false},"author":79,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_relevanssi_hide_post":"","_relevanssi_hide_content":"","_relevanssi_pin_for_all":"","_relevanssi_pin_keywords":"","_relevanssi_unpin_keywords":"","_relevanssi_related_keywords":"","_relevanssi_related_include_ids":"","_relevanssi_related_exclude_ids":"","_relevanssi_related_no_append":"","_relevanssi_related_not_related":"","_relevanssi_related_posts":"","_relevanssi_noindex_reason":"","footnotes":""},"categories":[1],"tags":[],"class_list":["post-47643","post","type-post","status-publish","format-standard","hentry","category-uncategorized","department-press-release"],"yoast_head":"\nUNMC College of Dentistry Researchers Receive More Than $2 Million to Study Effect of Drug on Preventing, Treating Oral Bone Loss<\/title>\n<meta name=\"description\" content=\"University of Nebraska Medical Center College of Dentistry researcher and dentist, Jeffrey B. 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