{"id":47747,"date":"2001-07-24T00:00:00","date_gmt":"2001-07-24T05:00:00","guid":{"rendered":"https:\/\/www.unmc.edu\/newsroom\/2001\/07\/24\/vitamin-e-and-selenium-to-be-tested-as-prevention-agents\/"},"modified":"2022-08-29T10:52:00","modified_gmt":"2022-08-29T15:52:00","slug":"vitamin-e-and-selenium-to-be-tested-as-prevention-agents","status":"publish","type":"post","link":"https:\/\/www.unmc.edu\/newsroom\/2001\/07\/24\/vitamin-e-and-selenium-to-be-tested-as-prevention-agents\/","title":{"rendered":"Vitamin E and Selenium to be Tested as Prevention Agents"},"content":{"rendered":"

<\/i><\/p>\n

Several Omaha Health Care Providers to Participate<\/p>\n

in Largest-Ever Prostate Cancer Prevention Trial<\/p>\n

 <\/p>\n

Healthy men age 55 and older are needed for the largest-ever prostate<\/p>\n

cancer prevention study, launched today by the National Cancer Institute.<\/p>\n

The Selenium and Vitamin E Cancer Prevention Trial, or SELECT, seeks to<\/p>\n

learn if these two dietary supplements can protect against prostate cancer,<\/p>\n

the most common form of cancer, after skin cancer, in men.<\/p>\n

More than 400 sites in the United States, Puerto Rico and Canada are<\/p>\n

recruiting participants for SELECT, which will take up to 12 years to complete.<\/p>\n

The study will include a total of 32,400 men.<\/p>\n

In Omaha, the University of Nebraska Medical Center and the Missouri<\/p>\n

Valley Cancer Consortium will head the research study. For UNMC, Ralph<\/p>\n

Hauke, M.D., an oncologist in the UNMC Eppley Cancer Center, will serve<\/p>\n

as principal investigator. James Mailliard, M.D., a Creighton University<\/p>\n

oncologist, will serve as principal investigator for the Missouri Valley<\/p>\n

Cancer Consortium.<\/p>\n

The UNMC portion of the study will allow men to participate at UNMC\/Nebraska<\/p>\n

Health System, Methodist Cancer Center, and Midwest Urology Associates.<\/p>\n

The Missouri Valley Cancer Consortium portion of the study will allow men<\/p>\n

to participate at Creighton Cancer Center, Alegent Health (Bergan Mercy<\/p>\n

Medical Center and Immanuel Medical Center), and the Cancer Resource Center<\/p>\n

in Lincoln. Each site is required to enroll at least 100 men over the first<\/p>\n

five years of the study.<\/p>\n

SELECT is the first study designed to look directly at the effects<\/p>\n

of vitamin E and selenium, both separately and together, in preventing<\/p>\n

prostate cancer, Dr. Hauke said. Previous research involving vitamin<\/p>\n

E and selenium suggested that these nutrients might prevent prostate cancer,<\/p>\n

but we dont know for sure. When SELECT is finished, we will know whether<\/p>\n

these supplements can prevent prostate cancer.<\/p>\n

Were delighted that Nebraska is part of this important national study,<\/p>\n

Dr. Mailliard said. With multiple sites participating in Omaha and one<\/p>\n

site in Lincoln, it should be very convenient for people to take part in<\/p>\n

the study.<\/p>\n

During this year alone, prostate cancer will be diagnosed in about 198,100<\/p>\n

Americans and more than 31,500 men are expected to die of the disease.<\/p>\n

In Nebraska, 1,200 men will get prostate cancer and 200 men will die of<\/p>\n

it. Risk factors for the disease include being over age 55, being black,<\/p>\n

or having a father or brother with prostate cancer.<\/p>\n

It is crucial that men of all races and ethnic backgrounds participate<\/p>\n

in SELECT, said Leslie Ford, M.D., associate director for clinical research<\/p>\n

in NCIs Division of Cancer Prevention. Since African-American men have<\/p>\n

the highest incidence of prostate cancer in the world, we especially encourage<\/p>\n

them to consider joining this trial.<\/p>\n

The disease also strikes black men at a younger age, so they will be<\/p>\n

eligible to enroll in the study at age 50, vs. age 55 for other racial<\/p>\n

and ethnic groups. There is no upper age limit for participation in SELECT.<\/p>\n

We are looking for quite a few good men to join SELECT, said Charles<\/p>\n

A. Coltman, Jr., M.D., chairman of the Southwest Oncology Group and director<\/p>\n

of the San Antonio Cancer Institute in San Antonio, Texas. This study<\/p>\n

is important for the men who join, not only because they might prevent<\/p>\n

prostate cancer for themselves, but also because what we learn has the<\/p>\n

potential to benefit future generations of men.<\/p>\n

Selenium and vitamin E, both naturally-occurring nutrients, are antioxidants.<\/p>\n

They are capable of neutralizing toxins known as free radicals that might<\/p>\n

otherwise damage the genetic material of cells and possibly lead to cancer.<\/p>\n

These nutrients were chosen for study because of the results of two other<\/p>\n

large cancer prevention trials.<\/p>\n

In a 1996 study of selenium to prevent one type of nonmelanoma skin<\/p>\n

cancer in 1,000 men and women, investigators found that while the supplement<\/p>\n

did not reduce skin cancer, it did decrease the incidence of prostate cancer<\/p>\n

in men by more than 60 percent.<\/p>\n

In another trial, published in 1998, beta carotene and vitamin E were<\/p>\n

tested to prevent lung cancer in 29,000 Finnish men who smoked. Neither<\/p>\n

beta carotene nor vitamin E prevented lung cancer, but those who took vitamin<\/p>\n

E had 32 percent less prostate cancer. In fact, the men who smoked and<\/p>\n

took beta carotene were more apt to get lung cancer and die from it than<\/p>\n

men who didnt take this supplement.<\/p>\n

SELECT is the critical next step for pursuing the promising leads we<\/p>\n

saw for the prevention of prostate cancer, said Dr. Ford, who is responsible<\/p>\n

for all aspects of NCIs involvement in SELECT.  The only way to<\/p>\n

determine the real value of these supplements for prostate cancer is to<\/p>\n

do a large clinical trial focused specifically on this disease.<\/p>\n

Study investigators hope to recruit all the study participants during<\/p>\n

the first five years of the trial, so that each man can be followed for<\/p>\n

at least seven years.<\/p>\n

In Nebraska, men participating in the study will be required to visit<\/p>\n

their participating health site once every six months. Upon enrollment,<\/p>\n

they will be assigned by chance to one of four groups. One group will take<\/p>\n

200 micrograms of selenium daily plus an inactive capsule, or placebo,<\/p>\n

that looks like vitamin E. Another group will take 400 milligrams of vitamin<\/p>\n

E daily along with a placebo that looks like selenium. A third group will<\/p>\n

take both selenium and vitamin E, and a final group will be given two placebos.<\/p>\n

Men who join SELECT will not need to change their diet in any way, but<\/p>\n

they must stop taking any supplements they buy themselves that may contain<\/p>\n

selenium or vitamin E. If participants wish to take a multivitamin, they<\/p>\n

will receive, without charge, a specially formulated one that does not<\/p>\n

contain selenium or vitamin E.<\/p>\n

Men may be able to participate in SELECT if they:<\/p>\n

·  are age 55 or older; age 50 or older for black men;<\/p>\n

· have never had prostate cancer and have not had any other cancer,<\/p>\n

except nonmelanoma skin cancer, in the last five years;<\/p>\n

·  are generally in good health.<\/p>\n

For more information about the study or prostate cancer:<\/p>\n

 · In the United States (including Puerto Rico), call the National<\/p>\n

Cancer Institutes Cancer<\/p>\n

Information Service at 1-800-4-CANCER (1-800-422-6237) for information<\/p>\n

in English or Spanish. The number for callers with TTY equipment is 1-800-332-8615.<\/p>\n

· Visit NCIs Web site at http:\/\/cancer.gov\/select or visit Southwest<\/p>\n

Oncology Groups Web site at http:\/\/swog.org and choose SELECT.<\/p>\n

· Contact the NCI Press Office, (301) 496-6641, or the Southwest Oncology<\/p>\n

Group, (210) 677-8808.<\/p>\n

Four pharmaceutical companies are providing selenium and vitamin E capsules<\/p>\n

and multivitamins for the study: Roche Vitamins Inc., Parsipanny, N.J.;<\/p>\n

Sabinsa Corporation, Piscataway, N.J.; Nutricia Manufacturing USA Inc.,<\/p>\n

Greenville, S.C.; and BioAdvantex Pharma Inc., Mississauga, Ontario, Canada.<\/p>\n<\/div><\/div>","protected":false},"excerpt":{"rendered":"

Several Omaha Health Care Providers to Participate in Largest-Ever Prostate Cancer Prevention Trial   Healthy men age 55 and older are needed for the largest-ever prostate cancer prevention study, launched today by the National Cancer Institute. The Selenium and Vitamin E Cancer Prevention Trial, or SELECT, seeks to learn if these two dietary supplements can […]<\/p>\n","protected":false},"author":79,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_relevanssi_hide_post":"","_relevanssi_hide_content":"","_relevanssi_pin_for_all":"","_relevanssi_pin_keywords":"","_relevanssi_unpin_keywords":"","_relevanssi_related_keywords":"","_relevanssi_related_include_ids":"","_relevanssi_related_exclude_ids":"","_relevanssi_related_no_append":"","_relevanssi_related_not_related":"","_relevanssi_related_posts":"","_relevanssi_noindex_reason":"","footnotes":""},"categories":[1],"tags":[],"class_list":["post-47747","post","type-post","status-publish","format-standard","hentry","category-uncategorized","department-press-release"],"yoast_head":"\nVitamin E and Selenium to be Tested as Prevention Agents<\/title>\n<meta name=\"description\" content=\"Several Omaha Health 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