{"id":47821,"date":"2003-03-05T00:00:00","date_gmt":"2003-03-05T06:00:00","guid":{"rendered":"https:\/\/www.unmc.edu\/newsroom\/2003\/03\/05\/unmc-unl-researchers-hope-to-become-experts-in-littleknown-organism-that-could-be-used-as-bioweapon\/"},"modified":"2022-08-29T10:45:21","modified_gmt":"2022-08-29T15:45:21","slug":"unmc-unl-researchers-hope-to-become-experts-in-littleknown-organism-that-could-be-used-as-bioweapon","status":"publish","type":"post","link":"https:\/\/www.unmc.edu\/newsroom\/2003\/03\/05\/unmc-unl-researchers-hope-to-become-experts-in-littleknown-organism-that-could-be-used-as-bioweapon\/","title":{"rendered":"UNMC, UNL researchers hope to become experts in little\n\nknown organism that could be used as bioweapon"},"content":{"rendered":"

Researchers at the University of Nebraska Medical Center and the University<\/p>\n

of Nebraska-Lincoln are collaborating on a $100,000 pilot study to conduct<\/p>\n

basic research on Francisella tularensis an organism that if used as<\/p>\n

a bioweapon, can cause tularemia, a potentially fatal disease.<\/p>\n

The project is supported by the University of Nebraska and Tobacco Settlement<\/p>\n

Funds through a program initiated by Tom Rosenquist, Ph.D., UNMC vice chancellor<\/p>\n

for research, and Prem Paul, Ph.D., UN-L vice chancellor for research and<\/p>\n

dean of graduate studies.<\/p>\n

Tularemia, also known as “rabbit fever,” is caused by a natural occurring<\/p>\n

bacterium found typically in wild animals, especially rodents, rabbits,<\/p>\n

and hares, and occasionally in pets such as cats. People come in contact<\/p>\n

with F. tularensis in a variety of ways, including through the bite of<\/p>\n

an infected insect, usually a tick or deerfly, handling infected animal<\/p>\n

carcasses, eating or drinking contaminated food or water, or breathing<\/p>\n

the bacteria.<\/p>\n

UNMC began the work in the last couple months as part of a continued<\/p>\n

plan to expand infectious disease research and build academic and research<\/p>\n

centers of excellence.<\/p>\n

UNMC has received approval from the U.S. Centers for Disease Control<\/p>\n

and Prevention (CDC) to serve as a repository for bacteria such as Francisella<\/p>\n

tularensis. UNMC researchers, in collaboration with scientists at UNL,<\/p>\n

are gathering information on the genetic makeup of the organism by performing<\/p>\n

tests to define the differences in multiple strains of F. tularensis.<\/p>\n

Weve always known that F. Tularensis is a highly infectious organism,<\/p>\n

said Paul Fey, Ph.D., UNMC assistant professor of internal medicine. But<\/p>\n

it hasnt been a priority for the National Institutes of Health until now.<\/p>\n

This is a unique opportunity for scientists and academicians to study<\/p>\n

this important organism and we hope our research will be an academic exercise<\/p>\n

that contributes to prevention of an attack, Dr. Fey said.<\/p>\n

F. Tularensis recently was classified by the U.S. government as a Category<\/p>\n

A agent, which has the greatest potential for causing harm if used in a<\/p>\n

bioterrorist attack. It can be dispersed in the air through aerosolization<\/p>\n

and inhaled in the lungs, similar to how bacillus anthracis (the bacterium<\/p>\n

that causes anthrax) and the smallpox virus can be used.<\/p>\n

This agent poses a high potential threat for use in bioterrorism and<\/p>\n

a risk to national security, said Pete Iwen, Ph.D., UNMC assistant professor<\/p>\n

of pathology and microbiology. Theres no good vaccine available for public<\/p>\n

use. In the past, it had limited use in the protection of lab workers and<\/p>\n

military personnel, but the FDA is reevaluating the vaccine because of<\/p>\n

problems associated with it.<\/p>\n

About 200 cases of tularemia, three to four in Nebraska, are diagnosed<\/p>\n

annually, Dr. Fey said. The death rate can be 40 to 60 percent if inhaled.<\/p>\n

Right now, theres not a great deal known about how the organism causes<\/p>\n

disease, Dr. Fey said.<\/p>\n

In the United States, tularemia is almost always a rural disease, according<\/p>\n

to the CDC, and is not known to be spread from person to person. People<\/p>\n

who have been exposed should be treated as soon as possible with antibiotics.<\/p>\n

The disease includes flu-like symptoms, and sometimes causes pneumonia<\/p>\n

which can result in chest pain, bloody sputum and breathing problems. Other<\/p>\n

symptoms depend on how a person was exposed. These symptoms can include<\/p>\n

ulcers on the skin, swollen and painful lymph glands, swollen and painful<\/p>\n

eyes, and a severe sore throat. Symptoms usually appear three to five days<\/p>\n

after exposure to the bacteria, but can take as long as 14 days.<\/p>\n

Drs. Fey and Iwen and others, are conducting basic research to learn<\/p>\n

more about the genetic makeup of F. tularensis to understand what genes<\/p>\n

or proteins in the organism cause the disease and ultimately develop an<\/p>\n

antigen a vaccine for protection against the organism.<\/p>\n

“We hope that our experience working with F. tularensis and other similar<\/p>\n

agents will enable us to expand our knowledge base and receive more funding,<\/p>\n

Dr. Fey said.<\/p>\n

To become involved in the national effort to combat bioterrorism, we<\/p>\n

asked where we could get involved that would give us the most opportunity,<\/p>\n

Dr. Iwen said. The literature showed there were many unanswered questions<\/p>\n

in tularensis research. Since we have one of the few laboratories in the<\/p>\n

U.S. approved by the CDC to conduct research on organisms such as F. tularensis,<\/p>\n

which requires high containment capabilities, we saw this as an opportunity.<\/p>\n

UNMC and UNL researchers have applied for a $26 million grant to the<\/p>\n

National Institutes of Health, with the ultimate goal of finding a new<\/p>\n

vaccine to prevent tularemia. The 4-inch-thick grant proposal names Steven<\/p>\n

Hinrichs, M.D., as the principal investigator, along with 29 researchers<\/p>\n

representing nine institutions in the midwest. Dr. Hinrichs is a UNMC professor<\/p>\n

of pathology and microbiology and director of the Nebraska Health System<\/p>\n

microbiology and virology laboratories.<\/p>\n

 <\/p>\n<\/a><\/div><\/div>","protected":false},"excerpt":{"rendered":"

Researchers at the University of Nebraska Medical Center and the University of Nebraska-Lincoln are collaborating on a $100,000 pilot study to conduct basic research on Francisella tularensis an organism that if used as a bioweapon, can cause tularemia, a potentially fatal disease. The project is supported by the University of Nebraska and Tobacco Settlement Funds […]<\/p>\n","protected":false},"author":79,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_relevanssi_hide_post":"","_relevanssi_hide_content":"","_relevanssi_pin_for_all":"","_relevanssi_pin_keywords":"","_relevanssi_unpin_keywords":"","_relevanssi_related_keywords":"","_relevanssi_related_include_ids":"","_relevanssi_related_exclude_ids":"","_relevanssi_related_no_append":"","_relevanssi_related_not_related":"","_relevanssi_related_posts":"","_relevanssi_noindex_reason":"","footnotes":""},"categories":[1],"tags":[],"class_list":["post-47821","post","type-post","status-publish","format-standard","hentry","category-uncategorized","department-press-release"],"yoast_head":"\nUNMC, UNL researchers hope to become experts in little known organism that could be used as bioweapon<\/title>\n<meta name=\"description\" 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