{"id":47849,"date":"2000-12-11T00:00:00","date_gmt":"2000-12-11T06:00:00","guid":{"rendered":"https:\/\/www.unmc.edu\/newsroom\/2000\/12\/11\/tailor-made-vaccines-give-new-hope-to-cancer-patients\/"},"modified":"2022-08-29T10:54:09","modified_gmt":"2022-08-29T15:54:09","slug":"tailor-made-vaccines-give-new-hope-to-cancer-patients","status":"publish","type":"post","link":"https:\/\/www.unmc.edu\/newsroom\/2000\/12\/11\/tailor-made-vaccines-give-new-hope-to-cancer-patients\/","title":{"rendered":"Tailor-made Vaccines Give New Hope to Cancer Patients"},"content":{"rendered":"

Patients with incurable follicular non-Hodgkin’s lymphoma may find new<\/p>\n

hope in a unique study involving the University of Nebraska Medical Center.<\/p>\n

UNMC is the first of 23 cancer centers in the country to participate<\/p>\n

in a clinical study assessing whether cancer vaccines, tailor made for<\/p>\n

the patient, elicit a specific immune response against the patient’s lymphoma.<\/p>\n

“This type of lymphoma is incurable with standard chemotherapy so we’re<\/p>\n

trying to keep patients in remission longer by adding the vaccine to their<\/p>\n

therapy,” said Julie Vose, M.D., professor of internal medicine – oncology\/hematology.<\/p>\n

The study is an extension of an earlier trial, in which UNMC and Stanford<\/p>\n

University were the sole participants. In that phase, patients with follicular<\/p>\n

lymphoma had a biopsy of their lymph node prior to treatment. The biopsy<\/p>\n

was sent to Genitope Corporation in Redwood City, Calif., a biotechnology<\/p>\n

company, which develops customized cancer vaccines for the patient using<\/p>\n

a recombinant DNA technology.<\/p>\n

“We were fortunate to participate in Phase II of the trial,” said Dr.<\/p>\n

Vose, who is principal investigator on the study with Ronald Levy, M.D.,<\/p>\n

professor of medicine at Stanford University School of Medicine. “Recombinant<\/p>\n

DNA technology is a new way to make the vaccine. They essentially cloned<\/p>\n

the tumor to produce a vaccine for the patient.”<\/p>\n

Genitope Corp., the trial’s sponsor, genetically engineered the tumor-derived<\/p>\n

vaccine to actively recruit the patient’s immune cells against the tumor,<\/p>\n

leaving other cells unharmed. In general, the body doesn’t recognize lymphomas<\/p>\n

or cancer as being a foreign substance. By changing the make-up of the<\/p>\n

cancer, researchers hope the body recognizes the need to attack, rather<\/p>\n

than accept, it.<\/p>\n

 <\/p>\n

Researchers hope the patient-specific immunotherapeutic approach will<\/p>\n

help treat the more than 25,000 patients newly diagnosed with follicular<\/p>\n

non-Hodgkin’s lymphoma each year in the United States.<\/p>\n

Preliminary data from the UNMC\/Stanford study was presented earlier<\/p>\n

this month at the 42nd annual meeting of the American Society of Hematology.<\/p>\n

According to the data, seven of 10 patients demonstrated specific immune<\/p>\n

responses to the vaccine, meaning their body recognized the cancer as foreign.<\/p>\n

Patients in the study received standard chemotherapy to put them in remission,<\/p>\n

followed by a series of vaccinations.<\/p>\n

“Our novel platform technology allows us to rapidly generate custom-made<\/p>\n

proteins to combat tumors,” said Dan Denney, Ph.D., chairman and chief<\/p>\n

executive officer of Genitope Corporation. “Based on the strength of these<\/p>\n

data, we have launched a multi-center randomized Phase III trial to assess<\/p>\n

the long-term disease-free survival of B cell non-Hodgkin’s lymphoma patients.”<\/p>\n

Over the next two years, UNMC, along with other medical centers will<\/p>\n

enroll 400 patients in the Phase III of the study. “This will allows us<\/p>\n

to see if we need a biopsy of the patient’s lymphoma,” Dr. Vose said.<\/p>\n

In this study, two-thirds of the patients will receive the custom made<\/p>\n

vaccine and one-third of the patients will receive only the non-specific<\/p>\n

immune stimulants following chemotherapy.<\/p>\n

“This will allow us to evaluate the need for the custom made vaccine<\/p>\n

or if non-specific stimulants of the immune system will be adequate to<\/p>\n

generate the anti-lymphoma effect,” Dr. Vose said.<\/p>\n

For more information, or to participate in the study, call Maribeth<\/p>\n

Hohenstein at 559-9053.<\/p>\n

 <\/p>\n<\/div><\/div>","protected":false},"excerpt":{"rendered":"

Patients with incurable follicular non-Hodgkin’s lymphoma may find new hope in a unique study involving the University of Nebraska Medical Center. UNMC is the first of 23 cancer centers in the country to participate in a clinical study assessing whether cancer vaccines, tailor made for the patient, elicit a specific immune response against the patient’s […]<\/p>\n","protected":false},"author":79,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_relevanssi_hide_post":"","_relevanssi_hide_content":"","_relevanssi_pin_for_all":"","_relevanssi_pin_keywords":"","_relevanssi_unpin_keywords":"","_relevanssi_related_keywords":"","_relevanssi_related_include_ids":"","_relevanssi_related_exclude_ids":"","_relevanssi_related_no_append":"","_relevanssi_related_not_related":"","_relevanssi_related_posts":"","_relevanssi_noindex_reason":"","footnotes":""},"categories":[1],"tags":[],"class_list":["post-47849","post","type-post","status-publish","format-standard","hentry","category-uncategorized","department-press-release"],"yoast_head":"\nTailor-made Vaccines Give New Hope to Cancer Patients<\/title>\n<meta name=\"description\" content=\"Patients with incurable follicular non-Hodgkin's lymphoma may find new hope in a unique study involving the University of Nebraska Medical Center. 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