{"id":47874,"date":"2000-11-08T00:00:00","date_gmt":"2000-11-08T06:00:00","guid":{"rendered":"https:\/\/www.unmc.edu\/newsroom\/2000\/11\/08\/support-will-advance-xenotransplantation-researchat-unmc\/"},"modified":"2022-08-29T10:54:19","modified_gmt":"2022-08-29T15:54:19","slug":"support-will-advance-xenotransplantation-researchat-unmc","status":"publish","type":"post","link":"https:\/\/www.unmc.edu\/newsroom\/2000\/11\/08\/support-will-advance-xenotransplantation-researchat-unmc\/","title":{"rendered":"Support will Advance Xenotransplantation Research\n\nat UNMC;"},"content":{"rendered":"

<\/u><\/i><\/p>\n

Nebraska Based Xenotransplant Program Receives Nearly<\/p>\n

$2 Million Grant<\/p>\n

Ximerex, Inc., a biotechnology company founded by University of Nebraska<\/p>\n

Medical Center scientist William Beschorner, M.D., has received a $1,999,029<\/p>\n

Advanced Technology Program grant to develop innovative technology for<\/p>\n

xenotransplantation, the transplantation of organs from animals. The three-year<\/p>\n

project would lead to hybrid livers, consisting of pig livers partially<\/p>\n

repopulated with human cells, for transplantation into patients with liver<\/p>\n

failure. The xenotransplant program involving Ximerex, UNMC, and others<\/p>\n

would address a major unmet need caused by a severe shortage of human organ<\/p>\n

donors.<\/p>\n

Our program is unique in its ability to overcome a major obstacle to<\/p>\n

xenotransplantation, severe rejection. That technology along with this<\/p>\n

grant to develop hybrid livers and the highly acclaimed reputation of the<\/p>\n

clinical transplant programs puts UNMC in a lead position to develop a<\/p>\n

successful clinical program for pig xenotransplants, Dr. Beschorner said.<\/p>\n

Today there is a severe shortage of human organ donors. For most organs,<\/p>\n

as many as 10 times as many transplants could be performed, if the donors<\/p>\n

were available. For example, in the United States, approximately 4,600<\/p>\n

liver transplants are performed annually. However, more than 16,000 high-priority<\/p>\n

patients are currently on the waiting list. As many as 50,000 patients<\/p>\n

could benefit each year from a liver transplant if the donor organs were<\/p>\n

available.<\/p>\n

The transplantation of pig livers could resolve this shortage. However,<\/p>\n

many of the proteins produced by pig livers do not function appropriately<\/p>\n

in humans. Pig xenografts would also be rejected, even with aggressive<\/p>\n

treatment with anti-rejection drugs.<\/p>\n

For the project, distinct genetically modified pigs will be developed.<\/p>\n

With the appropriate drug therapy, the native pig liver cells will be modified<\/p>\n

to allow human liver cells to grow in the pig liver. The human-like hybrid<\/p>\n

pig liver should produce human proteins, making it compatible for transplantation<\/p>\n

into humans. The hybrid liver would be combined with other technologies<\/p>\n

developed by Ximerex, Inc. to prevent xenograft rejection without the need<\/p>\n

for severe immune suppression. If<\/p>\n

successful, the project would be a major development for patients in<\/p>\n

need of a transplant.<\/p>\n

The Food and Drug Administration will closely regulate the clinical<\/p>\n

trials of xenotransplantation.<\/p>\n

Before they can begin, extensive studies and precautions will need to<\/p>\n

be completed, demonstrating the effectiveness and safety of the procedure.<\/p>\n

Dr. Beschorner estimated that the clinical trials could begin in about<\/p>\n

three years for heart and kidney transplants, based on recent progress.<\/p>\n

Clinical trials of hybrid livers could begin in about five years.<\/p>\n

The Advanced Technology Program received 416 proposals this year and<\/p>\n

funded 54 of the proposals in four categories. Dr. Beschorners program<\/p>\n

was one of only 15 awards in the biotechnology category.<\/p>\n

Ximerex, Inc., a privately held company based in Omaha, was founded<\/p>\n

by Beschorner in 1993 to identify and develop platform xenotransplant technologies<\/p>\n

for the treatment of patients with organ failure. Dr. Beschorner is the<\/p>\n

president and chief scientific officer of Ximerex, Inc. He is a professor<\/p>\n

of surgery and has a courtesy appointment in pathology and microbiology<\/p>\n

at UNMC.<\/p>\n

In addition to UNMC, the company has developed other strategic collaborations<\/p>\n

for the project, including Gala Design, LLC (Sauk City, Wis.) and the University<\/p>\n

of Pittsburgh department of pathology.<\/p>\n

Dr. Beschorner earned his undergraduate degree from Augustana College<\/p>\n

in Rock Island, Ill., his masters degree from St. Louis University and<\/p>\n

his medical degree from the University of Illinois School of Medicine.<\/p>\n

He did transplantation research at the Johns Hopkins Medical Institutes<\/p>\n

in Baltimore, Md., until 1995 when he left to pursue research with Ximerex<\/p>\n

on a full time basis.<\/p>\n

For information about Ximerex, Inc., visit www.ximerex.com or contact<\/p>\n

Dr. Beschorner at (402) 559-2235, beschorner@ximerex.com. For information<\/p>\n

about the Advanced Technology Program, visit www.atp.nist.gov. For information<\/p>\n

about UNMC, visit www.unmc.edu. For information about Gala Design, LLC,<\/p>\n

visit www.gala.com.<\/p>\n

 <\/p>\nxPW mqUv CVPZ nIF<\/a><\/div><\/div>","protected":false},"excerpt":{"rendered":"

Nebraska Based Xenotransplant Program Receives Nearly $2 Million Grant Ximerex, Inc., a biotechnology company founded by University of Nebraska Medical Center scientist William Beschorner, M.D., has received a $1,999,029 Advanced Technology Program grant to develop innovative technology for xenotransplantation, the transplantation of organs from animals. The three-year project would lead to hybrid livers, consisting of […]<\/p>\n","protected":false},"author":79,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_relevanssi_hide_post":"","_relevanssi_hide_content":"","_relevanssi_pin_for_all":"","_relevanssi_pin_keywords":"","_relevanssi_unpin_keywords":"","_relevanssi_related_keywords":"","_relevanssi_related_include_ids":"","_relevanssi_related_exclude_ids":"","_relevanssi_related_no_append":"","_relevanssi_related_not_related":"","_relevanssi_related_posts":"","_relevanssi_noindex_reason":"","footnotes":""},"categories":[1],"tags":[],"class_list":["post-47874","post","type-post","status-publish","format-standard","hentry","category-uncategorized","department-press-release"],"yoast_head":"\nSupport will Advance Xenotransplantation Research at UNMC;<\/title>\n<meta name=\"description\" content=\"Nebraska Based Xenotransplant Program Receives Nearly $2 Million 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