{"id":48900,"date":"2009-12-10T00:00:00","date_gmt":"2009-12-10T06:00:00","guid":{"rendered":"https:\/\/www.unmc.edu\/newsroom\/2009\/12\/10\/unmc-research-team-develops-new-mouthwash-formulation-that-protects-against-tooth-decay\/"},"modified":"2022-08-28T19:22:31","modified_gmt":"2022-08-29T00:22:31","slug":"unmc-research-team-develops-new-mouthwash-formulation-that-protects-against-tooth-decay","status":"publish","type":"post","link":"https:\/\/www.unmc.edu\/newsroom\/2009\/12\/10\/unmc-research-team-develops-new-mouthwash-formulation-that-protects-against-tooth-decay\/","title":{"rendered":"UNMC research team develops new mouthwash formulation that protects against tooth decay"},"content":{"rendered":"<div class=\"panel body-content\"><div class=\"panel__container\"><p>&nbsp;<span style=\"color: black\">A research team at the University of Nebraska Medical Center has developed a new mouthwash formulation that may provide long-term protection against tooth decay.<\/span><\/p>\n<div style=\"margin: 0in 0in 0pt;line-height: normal\"><span style=\"color: black\">The team, led by <\/span>Dong Wang, Ph.D., associate professor of pharmaceutical science in the UNMC College of Pharmacy, has developed a <span style=\"color: black\">novel<\/span><span> drug delivery system to carry antimicrobial agents directly to teeth. Their study was published in the November issue of <\/span><i><span style=\"color: black\">Antimicrobial Agents and Chemotherapy<\/span><\/i><span style=\"color: black\"> and was also reported in the Nov. 22 issue of <\/span><i>Science Daily. <\/i><\/div>\n<div style=\"margin: 0in 0in 0pt;line-height: normal\">&nbsp;<\/div>\n<div style=\"margin: 0in 0in 0pt;line-height: normal\"><span style=\"color: black\">One of the main contributing factors to dental cavities is overpopulation of acid-producing bacteria in biofilm that is present on the tooth surface, eventually causing dental decay. Dr. Wang&rsquo;s formulation would bind to the tooth surface and gradually release antimicrobials against cavity-forming bacteria such as <i>Streptococcus mutans<\/i>.<\/span><\/div>\n<div style=\"margin: 0in 0in 0pt;line-height: normal\">&nbsp;<\/div>\n<div style=\"margin: 0in 0in 0pt;line-height: normal\"><span>&ldquo;The beauty of this design is the simplicity. All one may have to do is their routine oral hygiene procedure and then rinse with the formulation that we have developed. It could protect the teeth over a long period of time,&rdquo; Dr. Wang said. &ldquo;The k<\/span><span style=\"color: black\">ey is to have the antimicrobials stay where they are most needed &ndash; the tooth surface.&rdquo;<\/span><\/div>\n<div style=\"margin: 0in 0in 0pt\">&nbsp;<\/div>\n<div style=\"margin: 0in 0in 0pt\"><span>In addition to its primary intent of cavity prevention for the general population, Dr. Wang&rsquo;s formulation could have many far-reaching implications &ndash; for the elderly in nursing homes who may not have a lot of access to dental care and for protection against an increased <\/span>risk of <span>heart disease<\/span>. <span>A recent study found that poor dental <\/span>hygiene <span>leads to <\/span>heart attack and stroke due to the bacteria having direct access to the bloodstream through bleeding gums.<\/div>\n<div style=\"margin: 0in 0in 0pt\">&nbsp;<\/div>\n<div style=\"margin: 0in 0in 0pt;line-height: normal\"><span style=\"color: black\">&ldquo;The general research theme here is to manipulate the drug concentration at its intended action sites,&rdquo; he said.<\/span><\/div>\n<div style=\"margin: 0in 0in 0pt\">&nbsp;<\/div>\n<div style=\"margin: 0in 0in 0pt;line-height: normal\">Based upon the same principle, Dr. Wang&rsquo;s research group also explores the potential of using the drug delivery systems that they have developed to improve the treatment of <span style=\"color: black\">arthritis, cancer, and several other inflammatory diseases.<\/span><\/div>\n<p>&nbsp;<\/p>\n<div style=\"margin: 0in 0in 0pt\"><span>A PCT (Patent Cooperation Treaty) patent application has been filed on this technology through UNeMed, the technology transfer arm of UNMC. In addition to further development of this technology, Dr. Wang and his colleagues are looking for funds to support a clinical trial and for a cGMP (current Good Manufacturing Practice) facility to manufacture this formulation.<\/span><\/div>\n<div style=\"margin: 0in 0in 0pt\">&nbsp;<\/div>\n<div style=\"margin: 0in 0in 0pt\"><span>&quot;This will be a great addition to the tools dentists have to fight tooth decay,&quot; said Richard Reinhardt, Ph.D., D.D.S.<\/span>, co-director of undergraduate periodontics at the UNMC College of Dentistry and one of the research collaborators.<\/div>\n<div style=\"margin: 0in 0in 0pt\">&nbsp;<\/div>\n<div style=\"margin: 0in 0in 0pt\">\n<div style=\"margin: 0in 0in 0pt\"><span style=\"color: black\">Lead author on the paper was graduate student Fu Chen, who conducted many of the experiments together with Xue Li, another coauthor of the paper. In addition to Dr. Reinhardt, other collaborators include Kenneth Bayles, Ph.D., <\/span>professor of pathology and microbiology in the College of Medicine; Xin-Ming Liu, research assistant professor of pharmaceutical sciences in the College of Pharmacy, and <span style=\"color: black\">Kelly Rice, Ph.D., from the University of Florida, Gainesville. <\/span><\/div>\n<\/div>\n<div style=\"margin: 0in 0in 0pt\">&nbsp;<\/div>\n<div style=\"margin: 0in 0in 0pt\"><span>A bacteria-fighting formulation may not sound pleasing to the taste buds &ndash; but the group plans to work on that aspect to help ensure general use. <\/span><\/div>\n<div style=\"margin: 0in 0in 0pt\">&nbsp;<\/div>\n<div style=\"margin: 0in 0in 10pt\"><span>&ldquo;We&rsquo;ll sure look at different flavors. It must be something palatable,&rdquo; Dr. Wang said.<\/span><\/div>\n<div style=\"margin: 0in 0in 0pt;line-height: normal\"><i><span style=\"font-size: 10pt\"><font color=\"#211d1e\">As the state&rsquo;s only academic health science center, UNMC is on the leading edge of health care. Breakthroughs are possible because hard-working researchers, educators and clinicians are resolved to work together to fuel discovery. <\/font><\/span><i><span style=\"font-size: 10pt\">In 2009, UNMC&rsquo;s extramural research support topped $100 million for the first time, resulting in the creation of 3,600 jobs in Nebraska. UNMC&rsquo;s academic excellence is shown through its award-winning programs, and i<span style=\"color: black\">ts educational programs are responsible for training more health professionals practicing in Nebraska than any other institution. Through its commitment to education, research, patient care and outreach, UNMC and its hospital partner, The Nebraska Medical Center, have established themselves as one of the country&#8217;s leading health care centers. UNMC&#8217;s physician practice group, UNMC Physicians, includes 550 physicians in 50 specialties and subspecialties who practice primarily in The Nebraska Medical Center. For more information, go to UNMC&rsquo;s Web site at www.unmc.edu. <\/span><\/span><\/i><\/i><\/div>\n<p>&nbsp;<\/p>\n<\/div><\/div>","protected":false},"excerpt":{"rendered":"<p>&nbsp;A research team at the University of Nebraska Medical Center has developed a new mouthwash formulation that may provide long-term protection against tooth decay. The team, led by Dong Wang, Ph.D., associate professor of pharmaceutical science in the UNMC College of Pharmacy, has developed a novel drug delivery system to carry antimicrobial agents directly to [&hellip;]<\/p>\n","protected":false},"author":79,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_relevanssi_hide_post":"","_relevanssi_hide_content":"","_relevanssi_pin_for_all":"","_relevanssi_pin_keywords":"","_relevanssi_unpin_keywords":"","_relevanssi_related_keywords":"","_relevanssi_related_include_ids":"","_relevanssi_related_exclude_ids":"","_relevanssi_related_no_append":"","_relevanssi_related_not_related":"","_relevanssi_related_posts":"","_relevanssi_noindex_reason":"","footnotes":""},"categories":[1],"tags":[],"class_list":["post-48900","post","type-post","status-publish","format-standard","hentry","category-uncategorized","department-press-release"],"yoast_head":"<!-- This site is optimized with 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