{"id":50021,"date":"2014-07-22T00:00:00","date_gmt":"2014-07-22T05:00:00","guid":{"rendered":"https:\/\/www.unmc.edu\/newsroom\/2014\/07\/22\/unmc-researchers-receive-10-million-grant-to-study-staphylococcus\/"},"modified":"2022-08-29T14:47:18","modified_gmt":"2022-08-29T19:47:18","slug":"unmc-researchers-receive-10-million-grant-to-study-staphylococcus","status":"publish","type":"post","link":"https:\/\/www.unmc.edu\/newsroom\/2014\/07\/22\/unmc-researchers-receive-10-million-grant-to-study-staphylococcus\/","title":{"rendered":"UNMC researchers receive $10 million grant to study staphylococcus"},"content":{"rendered":"<div class=\"panel body-content\"><div class=\"panel__container\"><p>\nResearchers at the University of Nebraska Medical Center have received a five-year grant for $10 million to continue work on a project to fight the growing threat of methicillin-resistant <em>Staphylococcus aureus<\/em> (MRSA).<\/p>\n<p>\nMRSA, a bacterium resistant to many antibiotics, is a big problem in hospitals and can cause wound infections to more invasive diseases. In 2011, about 721,800 health-care associated infections occurred in 648,000 hospital patients, according to the U.S. Centers for Disease Control and Prevention.&nbsp;About 75,000 patients died during their hospitalizations.<\/p>\n<p>\nKen Bayles, Ph.D., principal investigator of the program project grant, said he and his team are working on four projects first funded in 2009 by the National Institutes of Health National Institute of Allergy and Infectious Diseases.<\/p>\n<p>\nProjects will focus on biofilms produced by <em>Staphylococcus aureus<\/em> and understanding their role in causing infections of artificial devices. Biofilm is a natural biologic material that grows on surfaces &#8212; like the plaque on teeth before brushing.<\/p>\n<p>\n&ldquo;Biofilm can affect any manmade device that is implanted into our bodies,&rdquo; Dr. Bayles said. &ldquo;With more and more people getting implanted devices, including stents, pacemakers, catheters, orthopedic devices like knee and hip replacements, all are targets for staph infections.&rdquo;<\/p>\n<p>\nIt is&nbsp;estimated that&nbsp;the rate of infection of implanted devices is between 1 and 5 percent.&nbsp;He said infections happen in medical devices usually through contamination of the surgical wound.<\/p>\n<p>\n&ldquo;Getting rid of biofilm associated with implanted devices is difficult&nbsp;because biofilm bacteria are resistant to the antibiotics used to treat infections,&rdquo; Dr. Bayles said.<\/p>\n<p>\nIf antibiotics don&#039;t work, the device will need to be removed, followed by extensive antibiotic treatment, and then replacement with a new device. It&rsquo;s traumatic for the patient and adds a significant burden to health care costs, he said.<\/p>\n<p>\nThree of the projects will be conducted at UNMC and include Dr. Bayles, Paul Fey, Ph.D., and Tammy Kielian, Ph.D. The fourth project will be headed by Alex Horswill, Ph.D., at the University of Iowa.<\/p>\n<p>\n<em>Through world-class research and patient care, UNMC generates breakthroughs that make life better for people throughout Nebraska and beyond. Its education programs train more health professionals than any other institution in the state. Learn more at <\/em><a href=\"http:\/\/unmc.edu\/\"><em>unmc.edu<\/em><\/a><em> and follow us on social media. <\/em><\/p>\n<p>\n&nbsp;<\/p>\n<p>\n<a href=\"https:\/\/twitter.com\/unmc\">Twitter<\/a> &nbsp;|&nbsp; <a href=\"https:\/\/www.facebook.com\/unmcedu\">Facebook<\/a>&nbsp; |&nbsp; <a href=\"http:\/\/www.pinterest.com\/unmc\">Pinterest<\/a>&nbsp; | &nbsp;<a href=\"http:\/\/www.youtube.com\/user\/UNMCEDU\">YouTube<\/a><\/p>\n<p>\n&nbsp;<\/p>\n<\/div><\/div>","protected":false},"excerpt":{"rendered":"<p>MRSA is a big problem in hospitals.<\/p>\n","protected":false},"author":15,"featured_media":50022,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_relevanssi_hide_post":"","_relevanssi_hide_content":"","_relevanssi_pin_for_all":"","_relevanssi_pin_keywords":"","_relevanssi_unpin_keywords":"","_relevanssi_related_keywords":"","_relevanssi_related_include_ids":"","_relevanssi_related_exclude_ids":"","_relevanssi_related_no_append":"","_relevanssi_related_not_related":"","_relevanssi_related_posts":"","_relevanssi_noindex_reason":"","footnotes":""},"categories":[1],"tags":[],"class_list":["post-50021","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-uncategorized","topic-research","department-college-of-medicine","department-pathology-and-microbiology","department-press-release"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.2 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ 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