{"id":51864,"date":"2015-02-13T00:00:00","date_gmt":"2015-02-13T06:00:00","guid":{"rendered":"https:\/\/www.unmc.edu\/newsroom\/2015\/02\/13\/cellular-signaling-is-focus-of-cobre\/"},"modified":"2022-09-02T19:56:03","modified_gmt":"2022-09-03T00:56:03","slug":"cellular-signaling-is-focus-of-cobre","status":"publish","type":"post","link":"https:\/\/www.unmc.edu\/newsroom\/2015\/02\/13\/cellular-signaling-is-focus-of-cobre\/","title":{"rendered":"Cellular signaling is focus of COBRE"},"content":{"rendered":"<div class=\"panel body-content\"><div class=\"panel__container\"><p>\nTo Keith Johnson, Ph.D., director of the Nebraska Center for Cellular Signaling (NCCS) in the College of Dentistry, reaching phase III status, with a $4.9 million grant renewal, means the opportunity to turn a corner.<\/p>\n<p>\nJeffrey Payne, D.D.S., the College of Dentistry&rsquo;s associate dean for research, said the phase III status and renewal of the National Institutes of Health (NIH) grant &ldquo;will support collaborative research across UNMC colleges and departments in the area of cellular signaling and will facilitate the NCCS&rsquo; trajectory as a self-sustaining center.&rdquo;<\/p>\n<p>\nThrough its first two phases, the COBRE also placed emphasis on development of promising young faculty &#8211; and Steven Caplan, Ph.D., Jixin Dong, Ph.D., and Aimin Peng, Ph.D., were among those who used NCCS support as a springboard to their first independent NIH R01-type funding.<\/p>\n<p>\nIn its phase III inception, the COBRE will now support projects with co-principal investigators of more or less equal expertise in different areas. The cross-multidisciplinary college collaboration is designed to help keep the momentum going, even after NIH funding eventually stops.<\/p>\n<p>\nAdditionally, the COBRE&rsquo;s momentum was a factor in helping secure nearly $700,000 in funding from a Nebraska Research Initiative (NRI) grant in order for UNMC to acquire a new state-of-the-art super-resolution microscope. This microscope, which allows researchers to see things with up to 10 times greater resolution, offers tremendous opportunity for those who study cellular signaling. (See story page 20.)<\/p>\n<p>\n&ldquo;It is a potential game-changer for our COBRE,&rdquo; said Dr. Johnson, who also works in the oral biology department. &ldquo;What we look at is cell-cell adhesion events that happen at the cell surface.&rdquo; And now NCCS investigators can see them like never before.<\/p>\n<p>\nThe program began in 2003, shepherded through Phases I and II by the late Margaret Wheelock, Ph.D. The three phases have totaled $25 million in grant money. The COBRE is currently funded through 2018, making the College of Dentistry a national leader in the study of cellular signaling in cancer.<\/p>\n<p>\n&nbsp;<\/p>\n<\/div><\/div>","protected":false},"excerpt":{"rendered":"<p>To Keith Johnson, Ph.D., director of the Nebraska Center for Cellular Signaling (NCCS) in the College of Dentistry, reaching phase III status, with a $4.9 million grant renewal, means the opportunity to turn a corner.<\/p>\n","protected":false},"author":105,"featured_media":51865,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_relevanssi_hide_post":"","_relevanssi_hide_content":"","_relevanssi_pin_for_all":"","_relevanssi_pin_keywords":"","_relevanssi_unpin_keywords":"","_relevanssi_related_keywords":"","_relevanssi_related_include_ids":"","_relevanssi_related_exclude_ids":"","_relevanssi_related_no_append":"","_relevanssi_related_not_related":"","_relevanssi_related_posts":"","_relevanssi_noindex_reason":"","footnotes":""},"categories":[1],"tags":[],"class_list":["post-51864","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-uncategorized","department-discover","author_override-kalani-simpson-unmc-public-relations"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.2 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Cellular signaling is focus of 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