{"id":54772,"date":"2016-02-02T00:00:00","date_gmt":"2016-02-02T06:00:00","guid":{"rendered":"https:\/\/www.unmc.edu\/newsroom\/2016\/02\/02\/the-next-big-little-thing\/"},"modified":"2022-09-02T16:55:51","modified_gmt":"2022-09-02T21:55:51","slug":"the-next-big-little-thing","status":"publish","type":"post","link":"https:\/\/www.unmc.edu\/newsroom\/2016\/02\/02\/the-next-big-little-thing\/","title":{"rendered":"The next big little thing"},"content":{"rendered":"<div class=\"panel body-content\"><div class=\"panel__container\"><p>\nIt&rsquo;s the latest in cutting-edge technology in single cell genomics.<\/p>\n<p>\nAnd even though it doesn&rsquo;t look like much &#8211; a blue inconspicuous machine with a touchscreen of buttons and blinking lights &#8211; the information it can extract from a single cell is beyond amazing.<\/p>\n<p>\nAs recently as last year, a researcher who wanted to know what genes were important in a particular tumor would only be able to get a general idea of the tumor&rsquo;s composition with the help of high-throughput gene expression profiling methods.<\/p>\n<p>\nBut researchers want more specific information.<\/p>\n<p>\n&quot;Typically a researcher analyzes a DNA\/RNA sample extracted from a mixture of millions of cells, but so much more detailed information can be gleaned by analyzing the DNA\/RNA from individual cells,&quot; said Jim Eudy, Ph.D., director of the next generation DNA sequencing core facility.<\/p>\n<p>\nNow, thanks to a $500,000 grant from the Nebraska Research Initiative, researchers at UNMC will be able to do just that.<\/p>\n<p>\nWith the C1 Single-Cell Auto Prep Integrated Fluidic Circuit, researchers now have the capability of deciphering the differences in groups of cells that appear similar but possess fundamentally different properties.<\/p>\n<p>\nThe journal Nature Genetics deemed single cell genomics the &quot;Method of the Year&quot; in 2014 and called it a turning point poised to transform many areas of biology and medicine.<\/p>\n<p>\n&quot;It&rsquo;s the next big little thing,&quot; Dr. Eudy said. &quot;Single cell genomics technology is revolutionary.&quot;<\/p>\n<p>\nThere is currently no other single cell genomics instrumentation in the state, he said, adding that the new technology will be used as part of an interdisciplinary team combining the expertise of the genomics, flow cytometry, confocal imaging and bioinformatics core facilities, he said.<\/p>\n<p>\nHamid Band, M.D., Ph.D., director of the center for breast cancer research and associate director for translational research in the Eppley Institute at UNMC, said that because cancer cells exhibit a tremendous amount of cellular heterogeneity or diversity, the biological differences between those cells can be obscured using traditional sequencing methods.<\/p>\n<p>\nSingle cell genomics technology allows researchers a window into the mutational status and epigenetic landscape of individual cells that allows them to see such key properties of tumors as why some stay dormant for a long time only to recur years later, Dr. Band said.<\/p>\n<p>\n&quot;This will allow physicians to have advance information on which drugs will likely work as second or third line therapies in patients whose cancers recur.&quot;<\/p>\n<\/div><\/div>","protected":false},"excerpt":{"rendered":"<p>Getting down to the single cell in single cell genomics.<\/p>\n","protected":false},"author":101,"featured_media":54773,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_relevanssi_hide_post":"","_relevanssi_hide_content":"","_relevanssi_pin_for_all":"","_relevanssi_pin_keywords":"","_relevanssi_unpin_keywords":"","_relevanssi_related_keywords":"","_relevanssi_related_include_ids":"","_relevanssi_related_exclude_ids":"","_relevanssi_related_no_append":"","_relevanssi_related_not_related":"","_relevanssi_related_posts":"","_relevanssi_noindex_reason":"","footnotes":""},"categories":[1],"tags":[],"class_list":["post-54772","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-uncategorized","department-discover","author_override-lisa-spellman-unmc-public-relations"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.6 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>The next big little 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