{"id":54774,"date":"2016-02-02T00:00:00","date_gmt":"2016-02-02T06:00:00","guid":{"rendered":"https:\/\/www.unmc.edu\/newsroom\/2016\/02\/02\/treatment-for-inflammatory-bowel-disease-goes-nano-2\/"},"modified":"2022-09-02T16:55:39","modified_gmt":"2022-09-02T21:55:39","slug":"treatment-for-inflammatory-bowel-disease-goes-nano-2","status":"publish","type":"post","link":"https:\/\/www.unmc.edu\/newsroom\/2016\/02\/02\/treatment-for-inflammatory-bowel-disease-goes-nano-2\/","title":{"rendered":"Treatment for inflammatory bowel disease goes nano"},"content":{"rendered":"

\nThe 1.4 million predominantly young adults in the United States affected by inflammatory bowel disease (IBD) need help. The disease is bad enough – it includes chronic inflammation of the gastrointestinal (GI) tract that comes and goes. It’s painful, debilitating and comes with an increased risk of colon cancer.<\/p>\n

\nIBD, not yet fully understood, has no permanent cure. Some agent or a combination of agents – bacteria, viruses, antigens, or even the body’s own tissue – triggers the body’s immune system to<\/p>\n

\nproduce an inflammatory reaction in the intestinal tract.<\/p>\n

\nAnnual health care costs are more than $1.7 billion in the U.S. Treatment is palliative and lifelong. Biotechnological advances have brought new treatments – but these can be nearly as bad as the condition itself.<\/p>\n

\nAntibody-based treatments for IBD have to be given by injection and can be associated with severe side effects like Cushing’s syndrome, diabetes and osteoporosis. Not to mention the risk of infection.<\/p>\n

\nThank goodness for the drug delivery capabilities of particles. Thank goodness the UNMC College of Pharmacy is on the case.<\/p>\n

\nDavid Oupicky, Ph.D., professor of pharmaceutical sciences and co-director of the Center for Drug Delivery and Nanomedicine (CDDN), leads an effort on the development of a novel combination therapeutic strategy for an oral treatment of IBD based on particles recently developed in his lab.<\/p>\n

\nThere have been some challenges. Thanks in part to the problems presented by antibody-based treatments, the oral route is considered ideal for IBD treatment due to high patient compliance and direct access to the disease site. But, high enzymatic and nuclease activity, extreme pH conditions, and the physical mucus-epithelial barrier – all the acids and digestive enzymes in the<\/p>\n

\nstomach – can make oral treatments tough.<\/p>\n

\nIBD can change the GI environment, affecting the efficacy of traditional drug delivery methods.<\/p>\n

\nAgain, thank goodness for nanoparticles.<\/p>\n

\n"Particle formulations can extend the time the encapsulated drugs spend in the system," Dr. Oupicky said. "The use of mucoadhesive polymers, like chitosan, can further enhance time the drug stays in the GI tract to provide sustained release of active agents in the mucosa layer."<\/p>\n

\nBecause of their ability to target sites of intestinal inflammation, nanoparticles and microparticles offer multiple additional advantages for delivery of drugs in IBD.<\/p>\n

\nThrough chemistry, treatment can be selectively delivered to inflamed intestinal tissue either by "passive" or "active" targeting.<\/p>\n

\n"Passive targeting takes advantage of the size-selective accumulation of particles in the gastrointestinal inflammation sites," Dr. Oupicky said. Active targeting to selected sites and cells in the GI tract can be achieved by conjugation of specific ligands to the surface of the particles.<\/p>\n

\nThey are not there yet. But, Dr. Oupicky, the CDDN, and the College of Pharmacy, are working to help millions of people who suffer from this debilitating disease.<\/p>\n<\/div><\/div>","protected":false},"excerpt":{"rendered":"

Nanoparticles and microparticles offer multiple additional advantages for delivery of drugs in IBD.<\/p>\n","protected":false},"author":101,"featured_media":54775,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_relevanssi_hide_post":"","_relevanssi_hide_content":"","_relevanssi_pin_for_all":"","_relevanssi_pin_keywords":"","_relevanssi_unpin_keywords":"","_relevanssi_related_keywords":"","_relevanssi_related_include_ids":"","_relevanssi_related_exclude_ids":"","_relevanssi_related_no_append":"","_relevanssi_related_not_related":"","_relevanssi_related_posts":"","_relevanssi_noindex_reason":"","footnotes":""},"categories":[1],"tags":[],"class_list":["post-54774","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-uncategorized","department-discover","author_override-kalani-simpson-unmc-public-relations"],"yoast_head":"\nTreatment for inflammatory bowel disease goes nano<\/title>\n<meta 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