{"id":55789,"date":"2016-05-25T00:00:00","date_gmt":"2016-05-25T05:00:00","guid":{"rendered":"https:\/\/www.unmc.edu\/newsroom\/2016\/05\/25\/research-highlights-36\/"},"modified":"2016-05-25T00:00:00","modified_gmt":"2016-05-25T05:00:00","slug":"research-highlights-36","status":"publish","type":"post","link":"https:\/\/www.unmc.edu\/newsroom\/2016\/05\/25\/research-highlights-36\/","title":{"rendered":"Research highlights"},"content":{"rendered":"

\nUNMC College of Medicine faculty received 15 grant awards representing more than $1.8 million in new funding during the month of March. Highlights included:<\/p>\n

\nDeveloping a novel HIV-1 animal model<\/strong>                               <\/p>\n

\nSiddappa Byrareddy, Ph.D.,<\/strong> pharmacology & experimental neuroscience, has received a National Institutes of Health award for more than $100,000 from the National Institute of Allergy and Infectious Diseases to develop a more optimal animal model for studying clade 'C' HIV-1. Through the derivation of simian-human immunodeficiency viruses (SHIVs) that insert the human HIV genetic sequences into the animal viral sequence, the new animal models should more closely reproduce the human disease.                                                                                                                       <\/p>\n

\nIndustry-sponsored grants:<\/strong><\/p>\n

\nThe following industry-sponsored contracts and foundation grants also were received.  Information on clinical trials enrolling patients at UNMC can be found here<\/a>.<\/p>\n

\nCatherine Gebhart, Ph.D.,<\/strong> pathology and microbiology, has received support for the development of a research kit for Human Herpes Simplex Virus.<\/p>\n

\nDiana Do, M.D.,<\/strong> ophthalmology and visual sciences, is the UNMC lead on a phase III study assessing the safety and efficacy of the intravitreal administration of a study drug for the treatment of non-proliferative diabetic retinopathy.<\/p>\n

\nAaron Barksdale, M.D.,<\/strong> emergency medicine, is the UNMC lead on a clinical study of two novel in vitro diagnostic assays for the diagnosis of myocardial infarction.<\/p>\n

\nQuan Nguyen, M.D.,<\/strong> ophthalmology and visual sciences, is the UNMC lead on two separate clinical trials. A phase II study will assess the safety and efficacy of multiple intravitreal injections of a novel drug in patients presenting with geographic atrophy associated with age-related macular degeneration. A phase III study will test a novel ocular iontophoresis drug delivery system for the treatment of non-infectious anterior segment uveitis.<\/p>\n

\nJames Schwarz, M.D.,<\/strong> internal medicine – oncology\/hematology, is the UNMC lead on a phase III study of a novel combination therapy for patients with urothelial cancer who failed prior platinum-based therapy.<\/p>\n

\nKrishna Gundabolu, M.B.B.S.,<\/strong> internal medicine – oncology\/hematology, is the UNMC lead on a phase III study assessing the safety and comparing the effectiveness of two different drugs in reducing blood clots in patients with cancer-related venous thromboembolism, where a blood clot forms in a vein and then breaks off and moves through the bloodstream.<\/p>\n

\nFedja Rochling, M.B.B.C.H.,<\/strong> internal medicine – GI, is the UNMC lead on a phase II study to evaluate the effects of two doses of a study drug in patients with primary biliary cirrhosis having an inadequate response to ursodeoxycholic acid.<\/p>\n

\nWeining Zhen, M.D.,<\/strong> radiation oncology, is the UNMC lead on a study to test the efficacy and safety of an oral spray to prevent oral mucositis in patients receiving radiation and chemotherapy for the treatment of head and neck cancers.<\/p>\n

\nJingwei Xie, Ph.D.,<\/strong> surgery – transplant, has received support from the University of Nebraska Foundation for his study of local sustained delivery of vitamin D3 and other immune-boosting compounds in their ability to minimize surgical site infections.<\/p>\n

\nCyrus Desouza, M.B.B.S.,<\/strong> internal medicine – diabetes, endocrinology and metabolism, has received a Nebraska Educational Biomedical Research Association award to support a physician assistant for his VA Medical Center-sponsored research studies.<\/p>\n

\nStephen Rennard, M.D.,<\/strong> internal medicine – pulmonary, has received support from the Weill Medical College of Cornell University to design and test practical tools to identify individuals at a high risk for chronic obstructive pulmonary disease (COPD).<\/p>\n

\nSusan Swindells, M.B.B.S.,<\/strong> internal medicine – infectious diseases, has received support from Brigham & Women's Hospital as part of the AIDS Clinical Trials Group Network.<\/p>\n

\nDeepak Madhavan, M.D.,<\/strong> neurological sciences, is the UNMC lead on an observational study of the clinical outcomes of patients receiving vagal nerve stimulation therapy for treatment of drug-resistant epilepsy.<\/p>\n<\/a><\/div><\/div>","protected":false},"excerpt":{"rendered":"

UNMC College of Medicine faculty received 15 grant awards representing more than $1.8 million in new funding during the month of March. Siddappa Byrareddy, Ph.D., received an NIH award to study HIV-1 in an animal model.<\/p>\n","protected":false},"author":78,"featured_media":55792,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_relevanssi_hide_post":"","_relevanssi_hide_content":"","_relevanssi_pin_for_all":"","_relevanssi_pin_keywords":"","_relevanssi_unpin_keywords":"","_relevanssi_related_keywords":"","_relevanssi_related_include_ids":"","_relevanssi_related_exclude_ids":"","_relevanssi_related_no_append":"","_relevanssi_related_not_related":"","_relevanssi_related_posts":"","_relevanssi_noindex_reason":"","footnotes":""},"categories":[1],"tags":[],"class_list":["post-55789","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-uncategorized","department-intercom"],"yoast_head":"\nResearch highlights<\/title>\n<meta name=\"description\" content=\"UNMC College of Medicine faculty received 15 grant awards representing more than $1.8 million in new funding during the month of March. 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