{"id":58853,"date":"2017-05-18T00:00:00","date_gmt":"2017-05-18T05:00:00","guid":{"rendered":"https:\/\/www.unmc.edu\/newsroom\/2017\/05\/18\/easi-crispr-a-breakthrough-in-genome-engineering\/"},"modified":"2022-09-02T20:54:47","modified_gmt":"2022-09-03T01:54:47","slug":"easi-crispr-a-breakthrough-in-genome-engineering","status":"publish","type":"post","link":"https:\/\/www.unmc.edu\/newsroom\/2017\/05\/18\/easi-crispr-a-breakthrough-in-genome-engineering\/","title":{"rendered":"Easi-CRISPR a breakthrough in genome engineering"},"content":{"rendered":"

A study published May 17 in the journal Genome Biology<\/a> shows how highly popular, custom genetically engineered animal models are easily generated using a new, patent-pending technology called Easi<\/i> (Efficient additions with ssDNA inserts)-CRISPR. Easi<\/i>-CRISPR allows researchers to create these much-needed animal models at previously unheard of rates and significantly lower cost.<\/p>\n


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\n From left, Dr. Gurumurthy and his UNMC team, Rolen Quadros and Donald Harms.<\/span>
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\n“With Easi<\/i>-CRISPR, creating knock-in mice is as simple as using ‘Find’ and ‘Edit’ in Microsoft Word,” said Paula Turpen, Ph.D., director for research resources at UNMC. Dr. Turpen likened previous genetic-engineering methods to reading through a manuscript and making changes with a manual typewriter and a bottle of liquid “Wite-Out.”<\/p>\n

Channabasavaiah Gurumurthy, Ph.D., M.V.S.C. (D.V.M.),<\/a> associate professor of developmental neuroscience at UNMC’s Munroe-Meyer Institute, is primary investigator.<\/p>\n

Building off the CRISPR-Cas genome editing methods, Easi<\/i>-CRISPR is the crucial next step in genome engineering to create designer animal models.<\/p>\n

These models help scientists study the role of genes and mutations in human diseases, and explore the use of gene therapy and other potential treatments.<\/p>\n

CRISPR was a groundbreaking advance, allowing scientists to “cut” individual genes from a genome as a replacement for creating “knockout” models. But, generating more complicated knock-in and conditional knockouts — which comprise over 90 percent of animal models created — still proved inefficient, challenging and expensive.<\/p>\n

A recent Science Magazine<\/a> news article captured the frustration of the research community about the poor efficiency of the available CRISPR methods.<\/p>\n

Easi<\/i>-CRISPR, by contrast, enables the insertion of long DNA sequences into CRISPR-cut genomes at efficiencies of up to 100 percent.<\/p>\n

Dr. Gurumurthy said increased efficiencies are the result of inserting long single-stranded DNA, rather than double-stranded DNA. The idea came to his long-term collaborator, Masato Ohtsuka, Ph.D., of Japan’s Tokai University, while the two scientists were literally scribbling on a napkin at a conference in 2014.<\/p>\n

Dr. Gurumurthy said several independent labs have already been able to reproduce the Easi<\/i>-CRISPR study’s results<\/a>, thanks to its early online posting on the preprint server BioRxiv.<\/p>\n

Easi<\/i>-CRISPR is the result of an international collaboration between seven institutions, headed by Drs. Gurumurthy and Ohtsuka, with Dr. Suzanne Mansour of the University of Utah as a major collaborator. The collaboration includes Integrated DNA Technologies (IDT)<\/a>, a global leader in custom nucleic acid synthesis and genome editing products, based in Coralville, Iowa.<\/p>\n

“The present study demonstrates how efficiently DNA sequences can be introduced into a genome using long single-stranded DNA combined with Cas9 protein,” Mark Behlke, M.D., Ph.D., IDT’s chief scientific officer, said. “We are excited to help advance this field with our products. The work presented here<\/a> should be of high interest to everyone generating animal models using CRISPR technology.”<\/p>\n<\/div><\/div>","protected":false},"excerpt":{"rendered":"

Channabasavaiah Gurumurthy, Ph.D., M.V.S.C. (D.V.M.), is primary investigator on study published Wednesday in Genome Biology.<\/p>\n","protected":false},"author":27,"featured_media":58854,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_relevanssi_hide_post":"","_relevanssi_hide_content":"","_relevanssi_pin_for_all":"","_relevanssi_pin_keywords":"","_relevanssi_unpin_keywords":"","_relevanssi_related_keywords":"","_relevanssi_related_include_ids":"","_relevanssi_related_exclude_ids":"","_relevanssi_related_no_append":"","_relevanssi_related_not_related":"","_relevanssi_related_posts":"","_relevanssi_noindex_reason":"","footnotes":""},"categories":[1],"tags":[],"class_list":["post-58853","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-uncategorized","department-college-of-medicine","department-munroe-meyer-institute","department-unmc-today-todays-headlines","department-vice-chancellor-research","author_override-kalani-simpson-unmc-public-relations"],"yoast_head":"\nEasi-CRISPR a breakthrough in genome engineering<\/title>\n<meta name=\"description\" content=\"Channabasavaiah Gurumurthy, Ph.D., M.V.S.C. 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