{"id":60042,"date":"2017-09-20T00:00:00","date_gmt":"2017-09-20T05:00:00","guid":{"rendered":"https:\/\/www.unmc.edu\/newsroom\/2017\/09\/20\/compound-may-offer-new-deterrent-to-mosquitoes-2\/"},"modified":"2022-09-02T19:56:38","modified_gmt":"2022-09-03T00:56:38","slug":"compound-may-offer-new-deterrent-to-mosquitoes-2","status":"publish","type":"post","link":"https:\/\/www.unmc.edu\/newsroom\/2017\/09\/20\/compound-may-offer-new-deterrent-to-mosquitoes-2\/","title":{"rendered":"Compound May Offer New Deterrent To Mosquitoes"},"content":{"rendered":"<div class=\"panel body-content\"><div class=\"panel__container\"><p>Mosquitoes buzz, bite, suck our blood, make us itch and worst of all spread serious, even deadly diseases, like chikungunya, dengue, malaria, yellow fever and Zika.<\/p>\n<p>And if that isn&#039;t enough?<\/p>\n<p>&quot;A lot of people don&#039;t realize that mosquitoes have kidneys, and when they take a blood meal from you they also urinate on you almost simultaneously,&quot; Jerod Denton, Ph.D., of Vanderbilt University Medical Center, told NIH Research Matters.<\/p>\n<p>Eww.<\/p>\n<p>But now, UNMC is helping humans get revenge.<\/p>\n<p>Corey Hopkins, Ph.D., associate professor of pharmaceutical sciences, working out of the College of Pharmacy&#039;s UNMC Center for Drug Discovery, joins Dr. Denton and Peter Piermarini, Ph.D., at Ohio State, on a project that targets this, ahem, kidney function.<\/p>\n<p>&quot;They can actually give you a disease and pee on you at the same time,&quot; Dr. Denton told Scientific American.<\/p>\n<p>OK! We get the picture!<\/p>\n<p>Only, with the work being done by&nbsp; Dr. Hopkins and his colleagues, they can&#039;t do that.<\/p>\n<p>And that&#039;s bad for the mosquitoes. When mosquitoes suck your blood, they take in nutrients, but they also must eliminate the bad stuff immediately. That means&hellip; well, you know.<\/p>\n<p>But compounds designed and synthesized in Dr. Hopkins&#039; lab have been found to block kidney function in mosquitoes. Which means they can&#039;t&hellip;<\/p>\n<p>Ahem.<\/p>\n<p>Unable to flush out the system, they swell up, toxins taking them out from the inside. Some even literally burst.<\/p>\n<p>Dr. Hopkins sends compounds he makes to Dr. Denton for&nbsp; pharmacology testing, who sends them on to Dr. Piermarini for work on unsuspecting mosquitoes.<\/p>\n<p>Their study in the Nature-affiliated journal Scientific Reports calls it an &quot;insecticide resistance-breaking mosquitocide.&quot; That&#039;s important, because mosquitoes are developing resistance to the stuff we fight them with now.<\/p>\n<p>Thus far the compounds look safe for mammals and honeybees, but further testing is needed.<\/p>\n<p>It&#039;s the kind of world-leading impact envisioned by UNMC leadership and benefactors when planning the Center for Drug Discovery.<\/p>\n<p>Dr. Hopkins said: &quot;It is an exciting project to be involved with using my experience in medicinal chemistry to design new compounds with a novel mechanism of action in order to potentially make a major impact against these devastating diseases.&quot;<\/p>\n<p><h3>Web extra<\/h3>\n<\/p>\n<p><a href=\"http:\/\/www.nature.com\/articles\/srep36954\">Read<\/a> the journal article on mosquitocide.<\/p>\n<\/div><\/div>","protected":false},"excerpt":{"rendered":"<p>Mosquitoes buzz, bite, suck our blood, make us itch and worst of all spread serious, even deadly diseases, like chikungunya, dengue, malaria, yellow fever and Zika. And if that isn&#039;t enough? &quot;A lot of people don&#039;t realize that mosquitoes have kidneys, and when they take a blood meal from you they also urinate on you [&hellip;]<\/p>\n","protected":false},"author":119,"featured_media":60043,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_relevanssi_hide_post":"","_relevanssi_hide_content":"","_relevanssi_pin_for_all":"","_relevanssi_pin_keywords":"","_relevanssi_unpin_keywords":"","_relevanssi_related_keywords":"","_relevanssi_related_include_ids":"","_relevanssi_related_exclude_ids":"","_relevanssi_related_no_append":"","_relevanssi_related_not_related":"","_relevanssi_related_posts":"","_relevanssi_noindex_reason":"","footnotes":""},"categories":[1],"tags":[],"class_list":["post-60042","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-uncategorized","department-connect-old","author_override-kalani-simpson"],"yoast_head":"<!-- This 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malaria, yellow fever\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.unmc.edu\/newsroom\/2017\/09\/20\/compound-may-offer-new-deterrent-to-mosquitoes-2\/\" \/>\n<meta property=\"og:site_name\" content=\"Newsroom\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/unmcedu\" \/>\n<meta property=\"article:published_time\" content=\"2017-09-20T05:00:00+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2022-09-03T00:56:38+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.unmc.edu\/newsroom\/wp-content\/uploads\/2017\/09\/JPG_P_35_Compound_Hopkins.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"705\" \/>\n\t<meta property=\"og:image:height\" content=\"406\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Kasie Wilcox\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@unmc\" \/>\n<meta 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