{"id":61883,"date":"2018-05-07T00:00:00","date_gmt":"2018-05-07T05:00:00","guid":{"rendered":"https:\/\/www.unmc.edu\/newsroom\/2018\/05\/07\/unmc-researchers-aim-to-improve-hernia-mesh\/"},"modified":"2022-09-02T17:02:01","modified_gmt":"2022-09-02T22:02:01","slug":"unmc-researchers-aim-to-improve-hernia-mesh","status":"publish","type":"post","link":"https:\/\/www.unmc.edu\/newsroom\/2018\/05\/07\/unmc-researchers-aim-to-improve-hernia-mesh\/","title":{"rendered":"UNMC researchers aim to improve hernia mesh"},"content":{"rendered":"

UNMC faculty Mark Carlson, M.D., and Jingwei Xie, Ph.D., are working together on a solution for a better hernia mesh. And they think they may have found it.<\/p>\n

Holes in the abdomen can’t always be effectively sewn together, so they require a patch or “mesh.” <\/p>\n

Maybe someday regenerative medicine will (literally) fill that hole. “But we’re not there yet,” Dr. Carlson said.<\/p>\n

Instead, physicians now mainly use synthetic materials — plastics, which are, “Not perfect,” Dr. Carlson said. The body can have adverse reactions to foreign material.<\/p>\n

Or, “biologic mesh,” derived from derived from tissue such as skin, which is much more body-friendly. <\/p>\n

But, “I wince every time I use it,” Dr. Carlson said. Biologic mesh is so prohibitively expensive it requires level upon level of scrutiny by hospitals and insurance companies.<\/p>\n

We need something the human body will approve of, at a price the health care system will, too.<\/p>\n

Dr. Xie, a biomedical engineer in the Department of Surgery and Holland Regenerative Medicine Program at UNMC, and Dr. Carlson, a surgeon-scientist, who has a dual appointment at UNMC and the VA Nebraska Western-Iowa Health Care System, are developing a mesh engineered from man-made materials – synthetic polymers. But, which they believe will be much more friendly to living tissue.<\/p>\n

“The secret sauce is how you put (the particles) together,” Dr. Carlson said. “Dr.Xie is able to control things at the nano scale.”<\/p>\n

This means chemistry at the molecular level, to give the mesh “in vivo,” or living, characteristics. Its highly porous structure allows optimal cell and tissue growth.<\/p>\n

“The surface composition and nanotopography reduce the adhesion formation,” Dr. Xie said.<\/p>\n

Native tissue would incorporate it and form firm attachments. “The tissue actually grows into it — and that reduces the risk of infection and strengthens the native tissue,” Dr. Carlson said.<\/p>\n

The body would eventually absorb the material.<\/p>\n

The idea, and its initial preclinical data, have resulted in a grant from the Otis Glebe Medical Research Foundation. The team will test the mesh in porcine models in hopes of heading toward FDA testing and approval.<\/p>\n

Drs. Carlson and Xie are working with UNeMed, UNMC’s technology transfer arm, and are applying for a provisional patent of the technology. With further preclinical data, the team could partner with a private company, to keep the research moving, or apply for a small business grant.<\/p>\n

Through it all, “The Omaha VA has been enormously supportive of our lab,” Dr. Carlson said.<\/p>\n<\/a><\/div><\/div>","protected":false},"excerpt":{"rendered":"

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