{"id":63881,"date":"2019-01-14T00:00:00","date_gmt":"2019-01-14T06:00:00","guid":{"rendered":"https:\/\/www.unmc.edu\/newsroom\/2019\/01\/14\/university-of-nebraska-partners-with-dept-of-defense-to-develop-drug-therapies\/"},"modified":"2022-08-29T15:59:26","modified_gmt":"2022-08-29T20:59:26","slug":"university-of-nebraska-partners-with-dept-of-defense-to-develop-drug-therapies","status":"publish","type":"post","link":"https:\/\/www.unmc.edu\/newsroom\/2019\/01\/14\/university-of-nebraska-partners-with-dept-of-defense-to-develop-drug-therapies\/","title":{"rendered":"University of Nebraska partners with Dept. of Defense to develop drug therapies"},"content":{"rendered":"
The U.S. Department of Defense (DOD) has turned to the University of Nebraska to jumpstart the <\/span>development of drug therapies to protect military service members from the effects of radiation <\/span>exposure.<\/span>
\n <\/span>
\nIn an environment where for-profit pharmaceutical companies are often reluctant to embark upon <\/span>financially risky drug discovery efforts, the unique four-pronged partnership established by the university <\/span>and the DOD could shorten the U.S. military’s wait for drugs that prevent and counteract the effects of <\/span>radiation exposure.<\/span>
\n <\/span>
\n"It’s an exciting collaboration among the federal government, our state university and two of its premier <\/span>research campuses, UNMC and the University of Nebraska-Lincoln, and consultants from private <\/span>pharma who are Nebraska alumni," said David Berkowitz, Ph.D., professor of chemistry at UNL.<\/span>
\n <\/span>
\nThis team operates under the auspices of the NU National Strategic Research Institute (NSRI), one of <\/span>13 University Affiliated Research Centers (UARC) supported by the DOD. Nebraska has the lone UARC <\/span>entrusted by the military to work on chemical, biological, radiological and nuclear threats.<\/span>
\n <\/span>
\n"This research represents the broad capacity of the University of Nebraska and its alumni consultants to <\/span>tackle potentially hazardous radiation exposures around the world," said Lt. Gen. (Ret.) Robert Hinson, <\/span>NSRI’s founding executive director.<\/span>
\n <\/span>
\nThe NU project for the Defense Health Agency (DHA), and in collaboration with Armed Forces <\/span>Radiobiology Research Institute (AFRRI), has reached a second increment – potentially awarding nearly <\/span>$11 million in federal funding over the next five years. NU researchers will look for therapeutics <\/span>candidates the U.S. military would need to protect troops from radiation in case of exposure, as in a <\/span>nuclear accident or a nuclear weapons incident.<\/span>
\n <\/span>
\nLeveraging the full, collaborative strength of a united university system – multiple campuses, a network <\/span>of successful alums – directed by the DOD, is something new for NU.<\/span>
\n <\/span>
\n"I’ve never been involved with anything like that before," Dr. Berkowitz said. "This team came together as <\/span>a joint vision between the team leadership and our DOD funders and it’s pretty unusual across the <\/span>country to see such a public-private-government partnership."<\/span>
\n <\/span>
\nIn fact, the university hopes this opens the door to continued partnership with private pharma in the <\/span>longer term, through identifying and developing therapeutic candidates that have dual-purposing <\/span>potential, Dr. Berkowitz said.<\/span>
\n <\/span>
\nDr. Berkowitz is co-primary investigator of the project, with Ken Bayles, Ph.D., professor of pathology <\/span>and microbiology at UNMC.<\/span>
\n <\/span>
\nDr. Bayles said if private pharmaceutical companies are leaving a gap, the University of Nebraska is <\/span>eager to step in.<\/span>
\n <\/span>
\n"We’ve pitched this concept to develop a virtual pharmaceutical company, a drug development pipeline<\/span> that would coordinate the activities of all the expertise we have across all of our campuses and develop <\/span>capabilities to move molecules forward for drug development," he said.<\/span>
\n <\/span>
\nHandfuls of NU’s top scientists will work on medicinal chemistry, metabolomics and bioinformatics in <\/span>order to move potential drug candidates toward clinical trials. "We’ll be coordinating all of these aspects <\/span>like a pharmaceutical company does," Dr. Bayles said.<\/span>
\n <\/span>
\n"If we do it right, this pipeline concept is an opportunity to build the economy in Nebraska, build the <\/span>pharmaceutical industry in Nebraska," Dr. Bayles said.<\/span>
\n <\/span>
\n"It’s a complex machine," Dr. Berkowitz said of the new multi-pronged, multi-campus team. "And it’s <\/span>working pretty well now."<\/span>
\n <\/span>
\n"We are extremely proud to be affiliated with this research and the impact it can have for the Department <\/span>of Defense, Defense Health Agency and other agencies as well," Lt. Gen. Hinson said.<\/span>
\n <\/span><\/strong>
\nKey collaborators<\/span><\/strong>
\n <\/span>
\nThe following University of Nebraska scientists bring key expertise to the NSRI project to establish a <\/span>drug development pipeline that could speed the process of developing new drugs at the Armed Forces <\/span>Radiobiology Research Institute to counteract the effects of radiation exposure:<\/span>
\n <\/span>
\n• <\/span>Samuel Cohen, M.D., Ph.D., UNMC, toxicology.<\/span>
\n• <\/span>Patrick Dussault, Ph.D., UNL, synthetic chemistry.<\/span>
\n• <\/span>Babu Guda, Ph.D., UNMC, bioinformatics.<\/span>
\n• <\/span>Tomas Helikar, Ph.D., UNL, computational systems biology.<\/span>
\n• <\/span>DJ Murry, Pharm.D., UNMC, pharmacokinetics and pharmacogentics.<\/span>
\n• <\/span>Rebecca Oberley Deegan, Ph.D., UNMC, radiation therapeutics.<\/span>
\n• <\/span>Robert Powers, Ph.D., UNL, metabolomics.<\/span>
\n <\/span>
\nAdditionally, multiple University of Nebraska alums, all Ph.D. scientists, with current or former <\/span>experience in private pharma, also are involved.<\/span>
\n <\/span>
\nThis experienced consultant team includes Eugene Cordes of Philadelphia (honorary degree, UNL, <\/span>2009), Norton Peet, Holland, Mich. (Ph.D., UNL, chemistry, 1970), Kevin Woller, Antioch, Ill. (Ph.D., <\/span>UNL, chemistry, 1996), Chad Briscoe, Overland Park, Kan. (Ph.D., UNL, chemistry, 2009), Ryan <\/span>Hartung, Tuscon, Ariz. (B.S., UNL, chemistry, 2000).<\/span>
\n <\/span>
\n"They are appreciative of the opportunity to give back to their home institution," said David Berkowitz, <\/span>Ph.D., co-principal investigator, with Ken Bayles, Ph.D. "They really like the idea of the Lincoln and <\/span>Omaha campuses collaborating. They really like working for the DOD (Department of Defense). There is <\/span>a patriotic aspect of helping the country and protecting our troops using the tools of biomedical science. <\/span><\/div>\n
"That’s something that has made this project special for all of us," Dr. Berkowitz said.<\/span>
\n 
\n <\/div>\nZXBjfsXVXzlifYfg W<\/a><\/div><\/div>","protected":false},"excerpt":{"rendered":"

Goal is to protect military service members from effects of radiation exposure<\/p>\n","protected":false},"author":78,"featured_media":63882,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_relevanssi_hide_post":"","_relevanssi_hide_content":"","_relevanssi_pin_for_all":"","_relevanssi_pin_keywords":"","_relevanssi_unpin_keywords":"","_relevanssi_related_keywords":"","_relevanssi_related_include_ids":"","_relevanssi_related_exclude_ids":"","_relevanssi_related_no_append":"","_relevanssi_related_not_related":"","_relevanssi_related_posts":"","_relevanssi_noindex_reason":"","footnotes":""},"categories":[1],"tags":[],"class_list":["post-63881","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-uncategorized","topic-community","topic-research","topic-unmc-community","department-intercom","department-press-release"],"yoast_head":"\nUniversity of Nebraska partners with Dept. of Defense to 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