{"id":65654,"date":"2019-07-30T00:00:00","date_gmt":"2019-07-30T05:00:00","guid":{"rendered":"https:\/\/www.unmc.edu\/newsroom\/2019\/07\/30\/study-shows-ca19-9-may-contribute-to-cancer-progression\/"},"modified":"2022-09-02T16:57:13","modified_gmt":"2022-09-02T21:57:13","slug":"study-shows-ca19-9-may-contribute-to-cancer-progression","status":"publish","type":"post","link":"https:\/\/www.unmc.edu\/newsroom\/2019\/07\/30\/study-shows-ca19-9-may-contribute-to-cancer-progression\/","title":{"rendered":"Study shows CA19-9 may contribute to cancer progression"},"content":{"rendered":"

Scientists have known for years that CA19-9, a glycan, or carbohydrate structure, is an important biomarker for pancreatic cancer. Clinicians use it to monitor tumor progression.<\/p>\n

Basically, increasing CA19-9 levels suggests your cancer is getting worse; lowering CA19-9 suggests the patient is doing better.<\/p>\n

“In the setting of patients with disease who have elevated levels of CA19-9, increasing or decreasing levels often correlate with whether they are getting worse or better,” said Tony Hollingsworth, Ph.D., Hunt Chair in Cancer Research and Leon Professor in the Eppley Institute.<\/p>\n

But, what if the level of CA19-9 was not an indicator of worsening pancreatic cancer, but was also contributing to making the patient’s overall condition worse?<\/p>\n

It’s an idea that Dr. Hollingsworth has been working on for decades.<\/p>\n

That concept led to a recently completed study, published in Science<\/a>, showing that CA19-9 is associated with biological activity that may contribute to disease progression.<\/p>\n

“The important finding of this paper is that the molecules on which CA19-9 is expressed have biological activity in cancer,” Dr. Hollingsworth said.<\/p>\n

And maybe in other diseases as well — suggesting that therapy targeted at CA19-9 could help treat patients with pancreatitis, for example.<\/p>\n

But, back to the cancer aspect. Though this is a basic-science discovery, the project is an example of the kind of translational research that is now a major emphasis at the Fred & Pamela Buffett Cancer Center.<\/p>\n

It’s not always bench-to-bedside — instead, this time, bedside observations led to a bench breakthrough.<\/p>\n

Dr. Hollingsworth said the idea first came from “hints from the stories of patients” who had higher levels of CA19-9 as their prognosis grew worse.<\/p>\n

“We always thought it was disease burden. This paper suggests that those high and rising levels of CA19-9 may be contributing to the demise of the patients,” Dr. Hollingsworth said.<\/p>\n

Dr. Hollingsworth and other scientists will continue to study how carbohydrates attaching to proteins may contribute to cancer progression.<\/p>\n

“We believe some biomarkers contribute to both secondary effects and malignant aspects of cancer,” he said.<\/p>\n

This glycosylation of cancer is “poorly understood, but probably important,” Dr. Hollingsworth said.<\/p>\n

This latest discovery is yet another clue to understanding the disease, and thus, perhaps pointing someday toward more effective treatment.<\/p>\n

“This is just one step,” Dr. Hollingsworth said. “The story isn’t over.<\/p>\n

“But it’s a significant step.”<\/p>\n

The study was principally funded by UNMC’s A Longitudinal Cohort Study to Identify Clinical and Blood Markers of Early Pancreas Cancer grant<\/a>.<\/p>\n<\/div><\/div>","protected":false},"excerpt":{"rendered":"

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