{"id":67372,"date":"2020-03-06T00:00:00","date_gmt":"2020-03-06T06:00:00","guid":{"rendered":"https:\/\/www.unmc.edu\/newsroom\/2020\/03\/06\/biocompatible-foam-could-aid-wound-treatment\/"},"modified":"2022-09-02T17:40:24","modified_gmt":"2022-09-02T22:40:24","slug":"biocompatible-foam-could-aid-wound-treatment","status":"publish","type":"post","link":"https:\/\/www.unmc.edu\/newsroom\/2020\/03\/06\/biocompatible-foam-could-aid-wound-treatment\/","title":{"rendered":"Biocompatible foam could aid wound treatment"},"content":{"rendered":"

At the site of a rural car crash or on a military battlefield, first responders can have trouble stopping severe bleeding from what is called a junctional injury. That is, where an extremity meets the torso.<\/p>\n

The wound is too far inside to reach.<\/p>\n

“It’s difficult to treat in the field because you can’t apply direct pressure,” said Mark Carlson, M.D., professor of surgery. The patient is in real danger of bleeding to death.<\/p>\n

“We need to stabilize them, keep the patient alive long enough to make it through the transport phase,” Dr. Carlson said. “If the first responders can get the injured patient to a hospital alive, odds are, the patient will survive.”<\/p>\n

And so, Dr. Carlson, a surgeon-scientist, who has a dual appointment at UNMC and the VA Nebraska Western-Iowa Health Care System, is working again with his frequent partner and collaborator, Jingwei Xie, Ph.D.<\/p>\n

Dr. Xie is a biomedical engineer in the UNMC Department of Surgery and Holland Regenerative Medicine Program. The two like to team up to bring engineering solutions to surgical problems.<\/p>\n

They had an idea: a synthetic foam that would expand in the wounded cavity, stopping the leak, absorbing blood and applying pressure — to encourage clotting.<\/p>\n

“It’s a solid material, but it’s injectable,” Dr. Xie said. “We would pack it in a syringe.”<\/p>\n

Think foam packing peanuts, Dr. Carlson said.<\/p>\n

Or for a crude, but lay-friendly comparison, it’s a similar concept to DIY crack-filling spray foam insulation, or Fix a Flat temporary tire repair.<\/p>\n

But, “It’s biocompatible, the body would absorb it,” Dr. Carlson said.<\/p>\n

The raw material is a previously FDA-approved material. Dr. Xie and his lab are working on reformulating different nanostructures, in order to tweak its effectiveness.<\/p>\n

The idea is already receiving rave reviews. Drs. Carlson and Xie have worked with UNeMed, UNMC’s technology transfer company, and the invention has been licensed to a biomedical company that specializes in bleeding control.<\/p>\n

And their work is being funded by a three year, $2.2 million grant from the U.S. Department of Defense, which sees the potential to save the lives of U.S. service members.<\/p>\n

“There may be many, many crossover applications in the clinical realm,” Dr. Carlson said.<\/p>\n

For now, they are collecting data using pre-clinical pig models. They hope to leverage these findings into asking the FDA for an investigational device exemption (IDE) for human clinical trials.<\/p>\n<\/div><\/div>","protected":false},"excerpt":{"rendered":"

Researchers Jingwei Xie, Ph.D., and Mark Carlson, M.D., are funded by a Department of Defense grant.<\/p>\n","protected":false},"author":27,"featured_media":67373,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_relevanssi_hide_post":"","_relevanssi_hide_content":"","_relevanssi_pin_for_all":"","_relevanssi_pin_keywords":"","_relevanssi_unpin_keywords":"","_relevanssi_related_keywords":"","_relevanssi_related_include_ids":"","_relevanssi_related_exclude_ids":"","_relevanssi_related_no_append":"","_relevanssi_related_not_related":"","_relevanssi_related_posts":"","_relevanssi_noindex_reason":"","footnotes":""},"categories":[1],"tags":[],"class_list":["post-67372","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-uncategorized","topic-patient-care","topic-research","department-college-of-medicine","department-surgery","department-unmc-today-todays-headlines","department-vice-chancellor-research","author_override-kalani-simpson-unmc-public-relations"],"yoast_head":"\nBiocompatible 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