{"id":67606,"date":"2020-04-08T00:00:00","date_gmt":"2020-04-08T05:00:00","guid":{"rendered":"https:\/\/www.unmc.edu\/newsroom\/2020\/04\/08\/research-highlights-70\/"},"modified":"2022-08-29T16:45:48","modified_gmt":"2022-08-29T21:45:48","slug":"research-highlights-70","status":"publish","type":"post","link":"https:\/\/www.unmc.edu\/newsroom\/2020\/04\/08\/research-highlights-70\/","title":{"rendered":"Research highlights"},"content":{"rendered":"

The UNMC College of Medicine faculty received 36 grant awards representing $6.64 million in new funding during the months of February and March.<\/p>\n

M. Jana Broadhurst, M.D., Ph.D.,<\/b> pathology\/microbiology, has received a $1.68 million pass-through award from the Department of Defense for work on a project to develop a system that identifies previous exposure to materials that could be associated with weapons of mass destruction.<\/p>\n

Kenneth Bayles, Ph.D.,<\/b> pathology\/microbiology, has received a $733,000 award from the National Strategic Research Institute for a drug discovery and development project for medical countermeasures.<\/p>\n

Rey Carabeo, Ph.D.,<\/b> pathology\/microbiology, has received an NIH R01 investigating the regulatory role of tandem tryptophan codons in chlamydial persistence. The $598,000 award from the National Institute of Allergy and Infectious Disease will fund an investigation that will attempt to understand the processes that allow asymptomatic chlamydiae to survive. A better understanding of these organisms may lead to novel diagnostics or therapeutics for chronic chlamydial diseases.<\/p>\n

Irving Zucker, Ph.D.,<\/b> cellular\/integrative physiology, has received a renewed NIH R01 award from the National Heart, Lung, and Blood Institute for $570,000. The project will study the role of certain cardiac reflex pathways on the development of kidney failure in individuals with heart failure.<\/p>\n

Katherine Hyde, Ph.D.,<\/b> biochemistry and molecular biology, has received a $394,000 R01 award from the National Cancer Institute for a project, “The Role of the CBFB-MYH11 Complex in Leukemia Maintenance.”<\/p>\n

Rebekah Gundry, Ph.D.,<\/b> cellular\/integrative physiology, has received two R01 awards, both from the National Heart, Lung, and Blood Institute. The awards, totaling $706,000, are for two projects: “Cell Surface Phenotyping Human Primary Cells,” and “Cell Surface Proteins in Human Cardiomyocytes.”<\/p>\n

Erika Boesen, Ph.D.,<\/b> cellular\/integrative physiology, has received a $338,000 R01 award from the National Institute of Diabetes and Digestive and Kidney Diseases for the proposal, “Mechanisms of iron-mediated renal injury in lupus nephritis.” The project will investigate the mechanisms by which kidney injury occurs in populations with lupus to understand whether blocking these processes could serve as a new or complementary treatment strategy for lupus nephritis.<\/p>\n

Jason MacTaggart, M.D.,<\/b> vascular surgery, has received pass-through funding from the National Heart, Lung, and Blood Institute for his work on a project, “Effects of aortic compliance and Windkessel reduction on cardiac and aortic pathophysiology.” The project seeks to develop a new stent-graft to prevent damage to the heart.<\/p>\n

Maegen Wallace, M.D.,<\/b> orthopaedic surgery, has received pass-through funding from the National Institute of Arthritis and Musculoskeletal and Skin Diseases for work to support the Brittle Bone Disorders Consortium, focusing on rare bone diseases.<\/p>\n

Matthew Rizzo, M.D.,<\/b> neurological sciences, has received pass-through funding from the Department of Transportation for a project, “Deep InSight: Deep Extraction of Driver State from Naturalistic Driving Dataset.”<\/p>\n

Surinder Batra, Ph.D.,<\/b> biochemistry and molecular biology, has received funding from the Veterans Administration for lab services for Mucin signatures and molecular imaging for the early detection of colorectal cancer.<\/p>\n

Julie Vose, M.D.,<\/b> internal medicine – oncology\/hematology, has received pass-through funding from the National Cancer Institute for work with the City of Hope Lymphoma SPORE investigating therapy-related leukemia following autologous transplantation for lymphoma.<\/p>\n

Joshua Santarpia, Ph.D.,<\/b> pathology\/microbiology, has received funding from the National Strategic Research Institute to develop an aerosol collection system to be deployed on an unmanned aircraft. <\/p>\n

Kari Simonsen, M.D.,<\/b> pediatrics – infectious disease, has received pass-through funding from the National Institute of Allergy and Infectious Disease for a clinical trial as a part of the Acute Flaccid Myelitis Congenital and Perinatal Infections Rare Diseases Clinical Research Consortium through the University of Alabama-Birmingham.<\/p>\n

Pierre Fayad, M.D.,<\/b> neurological sciences, has received pass-through funding from the National Institute of Neurological Disorders and Stroke for a clinical trial as a part of the ARCADIA-CSI study through Stanford University.<\/p>\n

Ted Mikuls, M.D.,<\/b> internal medicine – rheumatology, has received technical salary support for his Veterans Affairs Nebraska Educational Biomedical Research Association rheumatology trials.<\/p>\n

Justin Cramer, M.D.,<\/b> radiology, has received pass-through funding from the National Institute of Neurological Disorders and Stroke for work supporting a project, “The influence of 3D printed prostheses on neural activation patterns of the primary motor cortex in children with unilateral congenital upper limb reductions.”<\/p>\n

Industry-sponsored grants and contracts:<\/b><\/p>\n

The following industry-sponsored contracts and foundation grants were received. Information on clinical trials enrolling patients at UNMC can be found here<\/a>.<\/i><\/p>\n

Cyrus Desouza, M.D.,<\/b> internal medicine – diabetes, endocrinology, and metabolism, will be the UNMC-lead investigator on an industry-sponsored, phase III randomized controlled trial investigating the safety and efficacy of a drug for individuals with moderate to advanced diabetic kidney disease.<\/p>\n

Vinicius Ernani, M.D.,<\/b> internal medicine – oncology\/hematology, will be the UNMC-lead on a phase I study investigating a novel therapeutic drug for patients with untreated extensive-stage small-cell lung cancer.<\/p>\n

Krishna Gundaboulu, M.B.B.S.,<\/b> internal medicine – oncology\/hematology, has received a work order to investigate the efficacy of certain drugs in patients with FLT3 mutated acute myeloid leukemia.<\/p>\n

Andrea Zimmer, M.D.,<\/b> internal medicine – infectious disease, will be the UNMC-lead on a phase III randomized controlled trial investigating the safety and efficacy of a novel therapeutic drug for immunocompromised individuals with lower respiratory tract parainfluenza infection. <\/p>\n

Robert Bociek, M.D.,<\/b> internal medicine – oncology\/hematology, will be the UNMC-lead on a phase II study evaluating a certain therapeutic drug in patients with chronic lymphocytic leukemia.<\/p>\n

Carol Toris, Ph.D.,<\/b> ophthalmology and visual sciences, received two industry-sponsored awards to investigate how certain compounds affect aqueous humor dynamics.<\/p>\n

Austin Thompson, M.D.,<\/b> internal medicine – pulmonary, will be the UNMC-lead on a study investigating the efficacy and safety of a certain drug to improve treatment outcomes in patients with pulmonary hypertension.<\/p>\n

Shaheed Merani, M.D.,<\/b> transplant surgery, has received funding to evaluate the effectiveness of a novel device to monitor and preserve donor livers for transplantation.<\/p>\n

Marcus Snow, M.D.,<\/b> internal medicine – rheumatology, will be the UNMC-lead on an industry-sponsored phase III randomized controlled trial evaluating the safety and efficacy of a certain drug in systemic sclerosis patients.<\/p>\n

Andrew Goldsweig, M.D.,<\/b> internal medicine – cardiovascular medicine, has received industry funding to collect evaluate performance and procedural outcomes associated with a novel transcatheter aortic heart valve.<\/p>\n

David Mercer, M.D., Ph.D.,<\/b> transplant surgery, will be the UNMC-lead on a randomized controlled trial evaluating a solution to keep intravenous vascular access devices unobstructed.<\/p>\n

Paul Fey, Ph.D.,<\/b> pathology\/microbiology, has received industry support for his project, “Recombinant Expression of Fusion Proteins for Vaccine Applications.”<\/p>\n

Danish Bhatti, M.D.,<\/b> neurological sciences, has received industry-sponsored funding to compare the usage of objective measurement using a monitoring device compared to standard-of-care in treating individuals with Parkinson’s Disease.<\/p>\n

Priscila Rodrigues Armijo, M.D.,<\/b> general surgery, has received funding from the American Hernia Society for her proposal, “Ergonomics of Inguinal Hernia Repairs with Mesh Fixation between Robotic, Laparoscopic and Open Procedures.”<\/p>\n

Baha Abdalhamid, M.D., Ph.D.,<\/b> pathology\/microbiology, has received funding to participate in a bone mineral density monitor registry.<\/p>\n

Christopher Ashwood, Ph.D.,<\/b> cellular\/integrative physiology, received a postdoctoral researcher award from the American Society for Mass Spectrometry.<\/p>\n

Rebecca Oberley-Deegan, Ph.D.,<\/b> biochemistry and molecular biology, received an award for her proposal, “Developing Pro-NP Nanoparticles for Prevention of Radiation-Induced Skin Reactions.”<\/p>\n<\/a><\/div><\/div>","protected":false},"excerpt":{"rendered":"

College of Medicine faculty received 36 grant awards representing $6.64 million in new funding during the months of February and March.<\/p>\n","protected":false},"author":27,"featured_media":63379,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_relevanssi_hide_post":"","_relevanssi_hide_content":"","_relevanssi_pin_for_all":"","_relevanssi_pin_keywords":"","_relevanssi_unpin_keywords":"","_relevanssi_related_keywords":"","_relevanssi_related_include_ids":"","_relevanssi_related_exclude_ids":"","_relevanssi_related_no_append":"","_relevanssi_related_not_related":"","_relevanssi_related_posts":"","_relevanssi_noindex_reason":"","footnotes":""},"categories":[1],"tags":[],"class_list":["post-67606","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-uncategorized","department-intercom"],"yoast_head":"\nResearch highlights<\/title>\n<meta name=\"description\" content=\"College of Medicine 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