{"id":69097,"date":"2020-10-09T00:00:00","date_gmt":"2020-10-09T05:00:00","guid":{"rendered":"https:\/\/www.unmc.edu\/newsroom\/2020\/10\/09\/research-highlights-74\/"},"modified":"2022-08-29T16:57:03","modified_gmt":"2022-08-29T21:57:03","slug":"research-highlights-74","status":"publish","type":"post","link":"https:\/\/www.unmc.edu\/newsroom\/2020\/10\/09\/research-highlights-74\/","title":{"rendered":"Research highlights"},"content":{"rendered":"<div class=\"panel body-content\"><div class=\"panel__container\"><p>The UNMC College of Medicine received new grant awards representing $6,986,832 in new funding in August.<\/p>\n<ul>\n<li><b>Sara Bares, MD<\/b>, internal medicine-infectious diseases, received a grant of $179,298 from the University of Colorado-Anschutz Medical Campus for the proposal, &#8220;Prospective pilot study of the efficacy, safety and tolerability of bctegravir-based HIV ART same-day treatment evaluation.&#8221;\n<li><b>Carol Casey, PhD<\/b>, internal medicine-GI, received a grant of $13,701 from the University of Nebraska-Lincoln for a proposal titled &#8220;Nebraska Center for the Prevention of Obesity Diseases through Dietary Molecules.&#8221;\n<li><b>Rebekah Dawson, PhD<\/b>, cellular and integrative physiology, received a grant of $457,065 from the NIH for the proposal, &#8220;Development of a next-generation glycomics platform to enable glycan structure analyses for precision medicine.&#8221;\n<li><b>Cyrus Desouza, MBBS<\/b>, internal medicine-DEM, received a grant of $57,930 for staff salary support to support his Nebraska Educational Biomedical Research Association-funded research.\n<li><b>Joseph Fernandes, MD<\/b>, neurological sciences, received four grants totaling $35,687 from Massachusetts General Hospital for the tasks orders one through four on platform-level site support and regimen specific appendices.\n<li><b>Andrew Goldsweig, MD<\/b>, internal medicine-cardiovascular, received a grant of $90,001 from Rutgers University for the proposal, &#8220;Myocardial Ischemia and Transfusion (MINT).&#8221;\n<li><b>Chi Lin, MD, PhD<\/b>, radiation oncology, received a grant of $59,100 from the Lahey Hospital &#038; Medical Center for the proposal, &#8220;A randomized multi-center Phase III study of individualized stereotactic body radiation therapy (SBRT) versus trans-arterial chemoembolization (TACE) as a bridge to transplant in hepatocellular carcinoma (HCC).&#8221;\n<li><b>James McClay, MD<\/b>, emergency medicine, received a grant of $20,000 from Duke Clinical Research Institute for the proposal, &#8220;Data use agreement: Using PCORnet to compare blood pressure control strategies Pro000100146.&#8221;\n<li><b>Russell Mcculloh, MD<\/b>, pediatrics, received a grant of $20,000 from Duke University for the proposal, &#8220;Pharmacokinetics of understudied drugs administered to children per standard of care.&#8221;\n<li><b>Ted Mikuls, MD<\/b>, internal medicine-rheumatology, received a grant of $140,396 from the University of Colorado-Anschutz Medical Center for the proposal, &#8220;Identifying key autoantibody and inflammatory factors in the initiation, propagation and transition to clinically-apparent rheumatoid arthritis.&#8221;\n<li><b>Satyanarayana Rachagani, PhD<\/b>, biochemistry and molecular biology, received a grant of $384,895 from the NIH for the proposal, &#8220;Targeting tumor and its microenvironment using nanotherapeutics for pancreatic cancer.&#8221;\n<li><b>Joshua Santarpia, PhD<\/b>, pathology\/microbiology, received a grant of $1,501,925 from the Battelle Memorial Institute for the proposal, &#8220;Environmental sampling for COVID-19.&#8221;\n<li><b>Nora Sarvetnick, PhD<\/b>, surgery-transplant, received a grant of $587,404 from the NIH for the proposal, &#8220;Uncovering pathogenic anti-bacterial defense mechanisms to identify novel targets for prevention of T1D.&#8221;\n<li><b>Vijay Shivaswamy, MBBS<\/b>, internal medicine-DEM, received three grants totaling $150,799 for staff salary support to support his Nebraska Educational Biomedical Research Association research.\n<li><b>Hanjun Wang, MD<\/b>, anesthesiology, received a grant of $14,257 from the University of Texas Southwestern Medical Center at Dallas for the proposal, &#8220;Targeting insulin resistance to improve abnormal cardiovascular control in diabetes.&#8221;\n<li><b>Tony Wilson, PhD<\/b> neurological sciences, received a grant of $1,924,688 from the NIH for the proposal, &#8220;New MEG system for improved quantification of human brain dynamics.&#8221;\n<li><b>Jingwei Xie, PhD<\/b>, surgery-transplant, received a grant of $488,000 from the NIH for the proposal, &#8220;Novel Janus-type antimicrobial dressings for the treatment of biofilms in chronic wounds.&#8221;<\/ul>\n<p><b>Industry-sponsored grants and contracts:<\/b><\/p>\n<p>The following industry-sponsored contracts and foundation grants were received. Information on clinical trials enrolling patients at UNMC can be found <a href=\"https:\/\/www.unmc.edu\/research\/clinical-trials\/index.html\">here<\/a>.<\/p>\n<ul>\n<li><b>Diana Florescu, MD<\/b>, internal medicine-infectious diseases, received funding for a master protocol assessing the safety, tolerability and efficacy of anti-spoke(s) SARA-COV-2 monoclonal antibodies for the treatment of hospitalized patients with COVID-19.\n<li><b>Hani Haider, PhD<\/b>, orthopaedic surgery, received funding for a work order on an in vitro wear durability study of UHMWPE tibial bearings from the double medical total knee replacement system.\n<li><b>Jennifer Merickel, PhD<\/b>, neurological sciences, received funding to explore &#8220;feasibility and utility of the car as a platform for monitoring behavior as an index of driver health and disease.&#8221;\n<li><b>Joshua Santarpia, PhD<\/b>, pathology\/microbiology, received funding for controlled bioaerosols assessment.\n<li><b>Kari Simonsen, MD<\/b>, pediatrics, received funding for &#8220;a Phase 2\/3 randomized, double-blind, palivizumab-controlled study to evaluate the safety of MEDI8897, a monoclonal antibody with an extended half-life against respiratory syncytial virus, in high-risk children.&#8221;\n<li><b>Carol Toris, PhD<\/b>, ophthalmology\/visual sciences, received funding to explore the &#8220;effect of an endothelin antagonist of PER-001 on intraocular pressure in monkeys.&#8221; She also received funding to explore &#8220;changes in outflow facility with a novel Schlemm&#8217;s canal drainage.&#8221;\n<li><b>Tammy Wichmann, MD<\/b>, internal medicine-pulmonary, received funding for &#8220;a prospective, multicenter study for the identification of biomarker signatures for early detection of pulmonary hypertension.&#8221;\n<li><b>Ronald Zolty, PhD<\/b>, internal medicine-cardiovascular, received funding for a Multicenter, randomized, double-blind, 90-day superiority trial to evaluate the effect on clinical benefit, safety and tolerability of once daily oral Empagliflozin 10 mg compared to placebo, initiated in patients hospitalized for acute heart.<\/ul>\n<!-- <a rel=\"nofollow\" href=\"\/secure-location.php\" title=\"rXQzo hs Qj \">rXQzo hs Qj <\/a> --><\/div><\/div>","protected":false},"excerpt":{"rendered":"<p>The UNMC College of Medicine received new grant awards representing $6,986,832 in new funding in August.<\/p>\n","protected":false},"author":27,"featured_media":69098,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_relevanssi_hide_post":"","_relevanssi_hide_content":"","_relevanssi_pin_for_all":"","_relevanssi_pin_keywords":"","_relevanssi_unpin_keywords":"","_relevanssi_related_keywords":"","_relevanssi_related_include_ids":"","_relevanssi_related_exclude_ids":"","_relevanssi_related_no_append":"","_relevanssi_related_not_related":"","_relevanssi_related_posts":"","_relevanssi_noindex_reason":"","footnotes":""},"categories":[1],"tags":[],"class_list":["post-69097","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-uncategorized","topic-research","department-anesthesiology","department-biochemistry-and-molecular-biology","department-cellular-and-integrative-physiology","department-emergency-medicine","department-intercom","department-internal-medicine","department-neurological-sciences","department-ophthalmology-and-visual-sciences","department-orthopaedic-surgery-and-rehabilitation","department-pathology-and-microbiology","department-pediatrics","department-radiation-oncology","department-surgery"],"yoast_head":"<!-- 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