{"id":69455,"date":"2020-11-09T00:00:00","date_gmt":"2020-11-09T06:00:00","guid":{"rendered":"https:\/\/www.unmc.edu\/newsroom\/2020\/11\/09\/unmc-team-makes-discovery-in-fighting-staphylococcus-aureus-infection\/"},"modified":"2022-09-02T20:06:19","modified_gmt":"2022-09-03T01:06:19","slug":"unmc-team-makes-discovery-in-fighting-staphylococcus-aureus-infection","status":"publish","type":"post","link":"https:\/\/www.unmc.edu\/newsroom\/2020\/11\/09\/unmc-team-makes-discovery-in-fighting-staphylococcus-aureus-infection\/","title":{"rendered":"UNMC team makes discovery in fighting Staphylococcus aureus infection"},"content":{"rendered":"

Imagine having hip or knee replacement surgery then needing to have it redone due to infection that sets in. Infections can result in additional surgery and hospitalization, considerable disability and prolonged recovery, as well as cost.
\n 
\nStaphylococcus aureus<\/em> (S. aureus<\/em>) is a leading cause of prosthetic joint infection that is characterized by biofilm formation – groups of bacteria that are held together by molecules that help them attach to surfaces, such as the orthopaedic hardware used for hip and knee replacements.
\n 
\nUniversity of Nebraska Medical Center researchers are working toward another way to treat S. aureus<\/em> infections in joint replacement surgery besides using antibiotics, which when used alone usually aren’t effective, said Tammy Kielian, Ph.D., Choudari Kommineni, DVM., PhD professor of pathology, UNMC Department of Pathology and Microbiology.
\n 
\nDr. Kielian and collaborators have published a study that appears in the October 2020 print issue of Nature Microbiology — <\/em>one of the leading journals in the field of microbiology.
\n 
\nShe said the work is the first to show that a bacterial metabolite is capable of changing the way that immune cells respond to S. aureus<\/em> biofilm. Findings suggest it might be possible to target the molecule in bacteria to prevent immune suppression, as well as help the immune system to clear an established infection.
\n 
\n“Our study identified a molecule that is produced by S<\/em>.<\/em> aureus<\/em> that promotes the anti-inflammatory activity of immune cells in prosthetic joint infections,” Dr. Kielian said. “We demonstrated this using our mouse model of S. aureus<\/em> prosthetic joint infection, and also in samples from patients suffering from these infections, demonstrating the potential of our findings to impact human disease.
\n 
\n“S. aureus<\/em> encodes a vast array of virulence factors that target immune defenses, and the ability to form a biofilm is another example of how it is able to circumvent elimination by the immune system,” she said. “Eradication of established S. aureus<\/em> biofilm typically requires surgery because antibiotics alone are not usually effective at clearing infection. This is because many of the bacteria in the biofilm are not actively dividing, which is one of the main features used by antibiotics to kill bacteria.”
\n 
\nDr. Kielian, who is senior author of the paper, said in addition, the study was the only paper in the October issue that was selected for a “News and Views” highlight, an honor reserved only for top papers considered to have a high impact.
\n 
\nThe three-year study was funded by the National Institutes of Health\/National Institute of Allergy and Infectious Diseases.
\n 
\nUNMC collaborators include Adam Karpf, PhD, Dave Klinkebiel, PhD, Vinai Thomas, PhD, Sujata Chaudhari, PhD, Kevin Garvin, MD, and Curtis Hartman, MD.
\n 
\nTo read about the study see:
\nLink to the online paper:  https:\/\/www.nature.com\/articles\/s41564-020-0756-3<\/a>
\nNews and Views highlight:  https:\/\/www.nature.com\/articles\/s41564-020-00791-x<\/a>
\nDr. Kielian’s blog post about the paper: https:\/\/naturemicrobiologycommunity.nature.com\/posts\/maestro-biofilm-orchestrating-an-anti-inflammatory-immune-response-through-bacterial-metabolites<\/a>
\n 
\nHip and knee infections occur in about 1-2% of orthopaedic surgeries, with S. aureus <\/em>being one of the most common causes. Infection after hip or knee replacement has a significant impact on patients as well as the healthcare system, with a projected economic burden in excess of $1.62 billion annually.
\n 
\nWe are <\/em>Nebraska Medicine<\/em><\/a> and <\/em>UNMC<\/em><\/a>. <\/em>Our mission is to lead the world in transforming lives to create a healthy future for all individuals and communities through premier educational programs, innovative research and extraordinary patient care.<\/em>
\n 
\nTwitter<\/a>  |  Facebook<\/a>  |  Instagram<\/a>  |  YouTube<\/a>  |  Flickr<\/a>
\n 
\n 
\n <\/p>\n<\/div><\/div>","protected":false},"excerpt":{"rendered":"

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