{"id":69904,"date":"2021-01-27T00:00:00","date_gmt":"2021-01-27T06:00:00","guid":{"rendered":"https:\/\/www.unmc.edu\/newsroom\/2021\/01\/27\/covid-19-paper-is-unmcs-most-cited-of-2020\/"},"modified":"2022-09-02T17:42:58","modified_gmt":"2022-09-02T22:42:58","slug":"covid-19-paper-is-unmcs-most-cited-of-2020","status":"publish","type":"post","link":"https:\/\/www.unmc.edu\/newsroom\/2021\/01\/27\/covid-19-paper-is-unmcs-most-cited-of-2020\/","title":{"rendered":"COVID-19 paper is UNMC&#8217;s most-cited of 2020"},"content":{"rendered":"<div class=\"panel body-content\"><div class=\"panel__container\"><p><P>A paper outlining a new, emerging infectious disease &#8212; COVID-19 &#8212; was UNMC&#8217;s most cited scientific publication of 2020. <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/32113704\/\">&#8220;The epidemiology and pathogenesis of coronavirus disease (COVID-19) outbreak,&#8221;<\/a> co-authored by Siddappa Byrareddy, PhD, associate professor and vice chair of research, pharmacology and experimental neuroscience, has been cited more than 1,000 times, and counting.<br \/>\n<P>That&#8217;s not surprising, said Jennifer Larsen, MD, vice chancellor for research. Dr. Byrareddy&#8217;s article is a great resource that brought together information other scientists were looking for in 2020, all in one place and easy to read.<br \/>\n<P>&#8220;Almost always,&#8221; she said, &#8220;review articles and guidelines are the most cited because they appeal to a broad audience.&#8221;<br \/>\n<P>What might we expect to see in a list of most cited research?<br \/>\n<P>After review articles, &#8220;Next comes large clinical trials, of course,&#8221; Dr. Larsen continued. &#8220;For the same reason. And those show up here, too.&#8221;<br \/>\n<P>Andre Kalil, MD, professor of infectious disease, who headed UNMC&#8217;s efforts in the first National Institutes of Health trial to evaluate experimental COVID-19 treatments, focusing on the anti-viral drug remdesivir, shows up twice in the top five.<br \/>\n<P>&#8220;Most seminal basic science isn&#8217;t recognized until long after it&#8217;s published, at least by citation index,&#8221; Dr. Larsen said. &#8220;Because anything revolutionary isn&#8217;t immediately embraced.&#8221;<br \/>\n<P>But it is informative to see which papers and manuscripts, with UNMC authors and contributors, were most cited by their colleagues across the world in 2020.<br \/>\n<P>Like a COVID-19 test result, citation numbers are but a snapshot in time, and may be different today than they were when recorded for this story.<br \/>\n<P>That said, the following are the top five most cited UNMC publications this past year:<br \/>\n<P><b><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/32113704\/\">The epidemiology and pathogenesis of coronavirus disease (COVID-19) outbreak<\/a><\/b><\/p>\n<ul>\n<li>Journal of Autoimmunity\n<li>Siddappa Byrareddy, PhD, associate professor and vice chair of research, pharmacology and experimental neuroscience, as second author\n<li>&#8220;In this review, we highlight the symptoms, epidemiology, transmission, pathogenesis, phylogenetic analysis and future directions to control the spread of this fatal disease.&#8221;\n<li>Cited by 1,025 documents<\/ul>\n<p><P><B><a href=\"https:\/\/www.nejm.org\/doi\/full\/10.1056\/NEJMoa2007764\">Remdesivir for the treatment of COVID-19 &#8211; Final report<\/a><\/b><\/p>\n<ul>\n<li>New England Journal of Medicine\n<li>Andre Kalil, MD, professor of infectious disease, among many other authors and ACTT-1 Study Group members\n<li>&#8220;Our data show that remdesivir was superior to placebo in shortening the time to recovery in adults who were hospitalized with Covid-19 and had evidence of lower respiratory tract infection.&#8221;\n<li>Cited by 750 documents<\/ul>\n<p><P><B><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/32025007\/\">Pan-cancer analysis of whole genomes<\/a><\/b> <\/p>\n<ul>\n<li>Nature\n<li>Tony Hollingsworth, PhD, Hunt Chair in Cancer Research, and Sarah Thayer, MD, PhD, chief of surgical oncology, among many members of the Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium\n<li>&#8220;A collection of papers from the PCAWG Consortium describes non-coding mutations that drive cancer beyond those in the TERT promoter; identifies new signatures of mutational processes that cause base substitutions, small insertions and deletions and structural variation; analyses timings and patterns of tumor evolution; describes the diverse transcriptional consequences of somatic mutation on splicing, expression levels, fusion genes and promoter activity; and evaluates a range of more-specialized features of cancer genomes.&#8221;\n<li>Cited by 183 documents<\/ul>\n<p><P><B><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/32208486\/\">Treating COVID-19 &#8211; Off-Label Drug Use, Compassionate Use, and Randomized Clinical Trials during Pandemics<\/a><\/b> <\/p>\n<ul>\n<li>Journal of the American Medical Association (JAMA)\n<li>Andre Kalil, MD, professor of infectious disease\n<li>&#8220;This unprecedented speed from concept to implementation in just a few weeks is noteworthy and provides proof that clinical trials can be promptly initiated even in the middle of a pandemic. The rapid and simultaneous combination of supportive care and RCTs is the only way to find effective and safe treatments for COVID-19 and any other future outbreak.&#8221;\n<li>Cited by 154 documents<\/ul>\n<p><P><B><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/31630479\/\">Apixaban and dalteparin in active malignancy-associated venous thromboembolism: The ADAM VTE trial<\/a><\/b><\/p>\n<ul>\n<li>Journal of Thrombosis and Haemostasis\n<li>Krishna Gundabolu, MBBS, assistant professor of oncology and hematology, as one of multiple authors.\n<li>&#8220;Oral apixaban was associated with low major bleeding and cancer-associated venous thromboembolism (VTE) recurrence rates for the treatment of VTE in cancer patients.&#8221;\n<li>Cited by 77 documents<\/ul>\n<\/div><\/div>","protected":false},"excerpt":{"rendered":"<p>The paper, co-authored by Siddappa Byrareddy, PhD, leads UNMC&#8217;s top five most-cited works of 2020.<\/p>\n","protected":false},"author":27,"featured_media":60984,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_relevanssi_hide_post":"","_relevanssi_hide_content":"","_relevanssi_pin_for_all":"","_relevanssi_pin_keywords":"","_relevanssi_unpin_keywords":"","_relevanssi_related_keywords":"","_relevanssi_related_include_ids":"","_relevanssi_related_exclude_ids":"","_relevanssi_related_no_append":"","_relevanssi_related_not_related":"","_relevanssi_related_posts":"","_relevanssi_noindex_reason":"","footnotes":""},"categories":[1],"tags":[],"class_list":["post-69904","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-uncategorized","department-college-of-medicine","department-covid-19","department-eppley-institute-for-cancer-research","department-fred-pamela-buffett-cancer-center","department-internal-medicine","department-pharmacology-and-experimental-neuroscience","department-unmc-front-page","department-unmc-today-todays-headlines","department-vice-chancellor-research","author_override-kalani-simpson-unmc-strategic-communications"],"yoast_head":"<!-- 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