{"id":71435,"date":"2021-07-30T00:00:00","date_gmt":"2021-07-30T05:00:00","guid":{"rendered":"https:\/\/www.unmc.edu\/newsroom\/2021\/07\/30\/unmc-study-sheds-more-light-on-covid-lung-disease\/"},"modified":"2022-08-29T17:12:48","modified_gmt":"2022-08-29T22:12:48","slug":"unmc-study-sheds-more-light-on-covid-lung-disease","status":"publish","type":"post","link":"https:\/\/www.unmc.edu\/newsroom\/2021\/07\/30\/unmc-study-sheds-more-light-on-covid-lung-disease\/","title":{"rendered":"UNMC study\u202fsheds\u202fmore\u202flight\u202fon\u202fCOVID, lung disease"},"content":{"rendered":"

A\u202fUniversity of Nebraska Medical Center\u202fteam\u202frecently\u202fpublished a study\u202fthat adds more insight into COVID-19 and some lung diseases. The\u202fpaper\u202fwas\u202fpublished\u202fJuly 6 online\u202fin\u202fCHEST<\/a>, a\u202fprominent medical\u202fjournal. <\/p>\n

"Our goal was to determine whether\u202fInterleukin-33 (IL-33)\u202fwas in the lungs of patients who did not survive COVID-19 and compare it to IL-33 expression\u202fin\u202fother inflammatory lung diseases," said\u202fJill Poole, MD,\u202fchief of the\u202fUNMC\u202fDepartment of Internal Medicine's\u202fDivision of Allergy and Immunology. She is\u202fsenior author of the\u202fresearch letter\u202ftitled, "IL-33 Depletion in COVID-19 Lungs."\u202f <\/p>\n

Other researchers\u202fhave reported\u202fthat blood levels of\u202fInterleukin-33 (IL-33)\u202fwere increased at time of hospitalization for COVID-19 and that high levels predicted poor outcomes for the\u202fSARS-Cov-2 infection.  <\/p>\n

Dr. Poole said in addition to its role in allergic asthma, previous studies have shown elevated IL-33 in the blood and\/or lung of those with chronic obstructive pulmonary disease\u202f(COPD) and end-stage lung disease.  <\/p>\n

A\u202fcomparative analysis of lung IL-33 expression in cases of\u202flong-term effects of a temporary disease or injury, such as in COVID,\u202fare lacking\u202fand thus the impetus for the UNMC study, she said.\u202fIL-33 plays an integral role in optimal functioning of the\u202flungs in wound repair, fibrosis, and remodeling processes. IL-33 is released\u202finside and outside of cells\u202ffollowing insult or damage induced by various infectious, noxious, or environmental agents.\u202f  <\/p>\n

Dr. Poole said using\u202fseveral\u202fUNMC\u202fbio-banks,\u202fresearchers\u202ffound\u202fthat IL-33 was profoundly depleted\u202f–\u202fessentially absent\u202f–\u202fin the lungs of all eight COVID-19 patients who did not survive COVID-19.\u202f  <\/p>\n

"IL-33\u202fin\u202fthese COVID patients were\u202fcompared\u202fto normal\u202fhuman lungs as well as those with COPD and\u202fchronic, progressive lung disease\u202fwho\u202fhad increased levels of lung IL-33," Dr. Poole said.\u202f"Interestingly, IL-33 levels were greatly increased in\u202fa survivor of\u202fCOVID-19\u202fwho\u202fdeveloped severe lung fibrosis\u202f(thickening or scarring)\u202ffollowing COVID-19 infection."\u202f  <\/p>\n

"Our study\u202fstrengthens\u202fthe relationship and importance of IL-33 in COVID-19,\u202fas well as its role in chronic inflammatory lung diseases," Dr. Poole said. "We suggest that\u202fadditional and longitudinal assessments\u202fthroughout\u202fthe\u202fCOVID-19 disease process\u202fare warranted. It is important\u202fto understand the mechanisms and timing\u202fof lung IL-33 expression and regulation for promoting damage or driving wound repair processes\u202ffor\u202fpotential interventional strategies\u202faimed at IL-33 in disease management."\u202f  <\/p>\n

First author\u202fof the paper\u202fis post-doctoral fellow Rohit Gaurav, PhD. The multi-disciplinary effort involved several UNMC\u202finternal medicine\u202fdivisions\u202fin addition to the departments of pathology and microbiology and the College of Public Health.\u202f <\/p>\n

The\u202fresearch\u202fwas\u202fcollectively\u202ffunded\u202fthrough\u202fUNMC grants\u202fand\u202fa variety of\u202ffederal\u202fsources.\u202f <\/p>\n

We are<\/em> <\/em>Nebraska Medicine<\/em><\/a> <\/em>and<\/em> <\/em>UNMC<\/em><\/a>.<\/em> <\/em>Our mission is to lead the world in transforming lives to create a healthy future for all individuals and communities through premier educational programs, innovative research and extraordinary patient care.<\/em>  <\/p>\n

Twitter<\/a>  |  Facebook<\/a>  |  Instagram<\/a>  |  YouTube<\/a>  |  Flickr<\/a> <\/p>\n<\/div><\/div>","protected":false},"excerpt":{"rendered":"

Using\u202fseveral\u202fUNMC\u202fbio-banks,\u202fresearchers\u202ffound\u202fthat IL-33 was profoundly depleted\u202f–\u202fessentially absent\u202f–\u202fin the lungs of all eight COVID-19 patients who did not survive COVID-19.\u202f <\/p>\n","protected":false},"author":15,"featured_media":71436,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_relevanssi_hide_post":"","_relevanssi_hide_content":"","_relevanssi_pin_for_all":"","_relevanssi_pin_keywords":"","_relevanssi_unpin_keywords":"","_relevanssi_related_keywords":"","_relevanssi_related_include_ids":"","_relevanssi_related_exclude_ids":"","_relevanssi_related_no_append":"","_relevanssi_related_not_related":"","_relevanssi_related_posts":"","_relevanssi_noindex_reason":"","footnotes":""},"categories":[1],"tags":[],"class_list":["post-71435","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-uncategorized","topic-research","department-college-of-medicine","department-internal-medicine","department-press-release"],"yoast_head":"\nUNMC study\u202fsheds\u202fmore\u202flight\u202fon\u202fCOVID, lung disease<\/title>\n<meta name=\"description\" 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