{"id":71576,"date":"2021-08-26T00:00:00","date_gmt":"2021-08-26T05:00:00","guid":{"rendered":"https:\/\/www.unmc.edu\/newsroom\/2021\/08\/26\/research-highlights-84\/"},"modified":"2022-08-29T17:13:53","modified_gmt":"2022-08-29T22:13:53","slug":"research-highlights-84","status":"publish","type":"post","link":"https:\/\/www.unmc.edu\/newsroom\/2021\/08\/26\/research-highlights-84\/","title":{"rendered":"Research highlights"},"content":{"rendered":"

The UNMC College of Medicine received grant and funding awards representing $11,037,387 in new funding in June.<\/p>\n

Xinglong Wang, PhD,<\/b> pharmacology\/experimental neuroscience, received a grant of $2,180,614 from DHS\/NIH\/NIA to study mitochondrial modulation of neuroinflammation in AD and related tauopathies.<\/p>\n

Russell McCulloh, MD, <\/b>pediatrics-hospitalists, received a grant of $1,508,470 from DHHS\/NIH\/NICD for mobile health-targeted SARS-CoV-2 testing and community interventions to maximize migrant children's school attendance during the COVID-19 pandemic.<\/p>\n

Howard Gendelman, MD,<\/b> pharmacology\/experimental neuroscience, received a grant of $710,244 for DHHS\/NIH\/NIAD for LASER ART for PrEP.<\/p>\n

William Rizzo, MD,<\/b> pediatrics-metabolism, received a grant of $574,963 from Children’s Mercy Hospital & Clinics of Kansas City, Missouri, for a genomics answers for kids repository.<\/p>\n

Karuna Rasineni, PhD,<\/b> internal medicine-GI, received a grant of $339,215 from DHHS\/NIH\/NIAA for a study on the role of alcohol-induced ghrelin in modulating organ cross-talk to promote the development of fatty liver disease.<\/p>\n

Padmashri Ragunathan, PhD,<\/b> neurological sciences, received a grant of $303,635 from Creighton University for a translational hearing center.<\/p>\n

Howard Fox, MD, PhD,<\/b> neurological sciences, received a grant of $229,500 from DHHS\/NIH\/NIMH to study macrophages and microglia, gene expression and chromatin: Illuminating the myeloid viral reservoir in the brain through single cell analyses. Dr. Fox also received a grant of $127,659 from Boys Town National Research Hospital for "Signatures of Cannabis Abuse in NeuroHIV (SCAN): An Integrated Molecular and Imaging Approach."<\/p>\n

Shanna Ratnesar-Shumate, PhD,<\/b> pathology\/microbiology, received a grant of $182,122 from the National Strategic Research Institute for measurement of the Optimal Growth Conditions and Stability of Yersinia pestis and a grant of $140,023 from the NSRI for measurement of the optimal growth conditions and stability of Francisella Tularensis.<\/p>\n

Heather Thomas, MD,<\/b> pediatrics-pulmonary, received a grant of $152,075 from the Cystic Fibrosis Foundation for a Cystic Fibrosis Care, Teaching and Research Center.<\/p>\n

James Murphy, MD,<\/b> internal medicine-pulmonary, received a grant of $149,520 from the Cystic Fibrosis Foundation for a CFF Center adult program.<\/p>\n

Mark Rupp, MD,<\/b> internal medicine-infectious diseases, received a grant of $132,761 from Duke University for a phase 2b, multicenter, randomized, open-label, assessor-blinded superiority study to compare the efficacy and safety of Dalbavancin to standard of care antibiotic therapy for the completion of treatment of patients with complicated S. aureus bacteremia.<\/p>\n

Apar Ganti, MD,<\/b> internal medicine-oncology\/hematology, received a grant of $122,452 from the Big Ten Cancer Research Consortium for a work order: A randomized phase II trial of adjuvant Pembrolizumab versus observation following curative resection for stage I non-small cell lung cancer (NSCLC) with primary tumors between 1-4 cm.<\/p>\n

Jasmine Marcelin, MD,<\/b> internal medicine-infectious diseases, received a grant of $90,684 from the Fred Hutchinson Cancer Research Center for a CoVPN 3006 protocol co-chair COVID-19 Prevention Network (CoVPN).<\/p>\n

Shuai Li, MD,<\/b> surgery-vascular surgery, received a grant of $77,000 from the American Heart Association to study autophagy in peripheral artery disease: Clinical significance and therapeutic potential.<\/p>\n

Dongze Zhang, MD,<\/b> emergency medicine, received a grant of $76,967 from the American Heart Association to study cardiac postganglionic sympathetic neurons and antiarrhythmic effect of renal denervation in chronic heart failure<\/p>\n

Daniel Johnson, MD,<\/b> anesthesiology, received a grant of $71,451 from McMaster University for REVISE (Re-Evaluating the Inhibition of Stress Erosions: Gastrointestinal Bleeding).<\/p>\n

Robert Bociek, MD,<\/b> internal medicine-oncology\/hematology, received a grant of $61,863 from the Hoosier Cancer  Research Network for a work order: Phase IB dose de-escalation study of the PI3k alpha\/delta inhibitor, Copanlisib given in combination with the immunotherapeutic agents, Nivolumab and Rituximab in patients with relapsed\/refractory indolent lymphoma.<\/p>\n

Kusum Kharbanda, PhD,<\/b> internal medicine-GI, received a grant of $61,411 from the VA Medical Center of Omaha to study impaired methylation alters lipid droplet dynamics in liver and adipose tissue: Role in hepatic steatosis.<\/p>\n

Javeed Iqbal, PhD,<\/b> pathology\/microbiology, received a grant of $50,000 from the Nebraska DHHS for delineating epigenetic reprogramming in Angioimmunoblastic T-cell lymphoma using murine models.<\/p>\n

Anupam Kotwal, MBBS,<\/b> internal medicine-DEM, received a grant of $50,000 from the Nebraska DHHS to study immune markers for thyroid cancer prognosis.<\/p>\n

Nicole Shonka, MD,<\/b> internal medicine-omcology\/hematology, <\/b>received a grant of $50,000 from the Nebraska DHHS for repurposing anti-histamine Brompheniramine for adjunct therapy in glioblastoma.<\/p>\n

Ying Yan, PhD, <\/b>radiation oncology, received a grant of $50,000 from the Nebraska DHHS for negative regulation of PR55-alpha protein stability by p53 tumor suppressor.<\/p>\n

Sowmya Yelamanchili, PhD,<\/b> anesthesiology, received a grant of $50,000 from the Nebraska DHHS to study sex specific brain derived EVs as potential markers for nicotine addiction.<\/p>\n

Michel Ouellette, PhD,<\/b> internal medicine-GI, received a grant of $50,000 from the Nebraska DHHS to study Rho GTPases in the radioresponse of pancreatic cancer.<\/p>\n

Abhijit Aithal, PhD,<\/b> biochemistry and molecular biology, received a grant of $50,000 from the Nebraska DHHS for testing a novel immunotherapy regimen for combating pancreatic cancer.<\/p>\n

Sukhwinder Kaur, PhD,<\/b> biochemistry and molecular biology, received a grant of $50,000 from the Nebraska DHHS for liquid biopsy for pancreatic cancer detection.<\/p>\n

Kishor Bhakat, PhD,<\/b> genetics, cell biology and anatomy, received a grant of $50,000 from the Nebraska DHHS for dysregulation of APE1 acetylation promotes oncogenesis.<\/p>\n

Matthew Halanski, MD,<\/b> orthopaedic surgery, received a grant of $45,000 from the Edna Ittner Trust Fund UN Foundation for improving the Ponseti method through technology.<\/p>\n

Chi Zhang, MD, PhD, <\/b>radiation oncology, received funding for a phase I\/II study to test the immunostimulatory effects of consolidative hypofractionated radiation therapy (hfRT) for boosting the residual primary lung cancer in combination with anti-PD-L1 immunotherapy after definitive chemoradiation therapy.<\/p>\n

Abenaya Muralidharan, PhD,<\/b> pathology\/microbiology, received a grant of $40,979 from the government of Canada for a study on understanding the balance between stimulatory and suppressive functions of neutrophils during SARS-CoV-2 infection.<\/p>\n

Kristy Carlson, PhD,<\/b> otolaryngology-head and neck surgery, received a grant of $40,000 from the Omaha Community Foundation for auditory research.<\/p>\n

Sookyong Koh, MD, PhD,<\/b> pediatrics-neurology, received a grant of $20,000 from the American Epilepsy Society for a novel murine model of febrile infection-related epilepsy syndrome (FIRES).<\/p>\n

Amy Hellman, MD,<\/b> neurological sciences, received a grant of $19,250 from the Huntington’s Disease Society of America. Dr. Hellman also received funding for an open-label rollover study for Continuing Valbenazine Administration for the Treatment of Chorea Associated with Huntington Disease.<\/p>\n

Susan Swindells, MBBS,<\/b> internal medicine-infectious diseases, received a grant of $15,750 from the University of California-Los Angeles for leadership and operations center, AIDS Clinical Trail Group.<\/p>\n

Ted Mikuls, MD,<\/b> internal medicine-rheumatology, received a grant of $15,000 from the Rheumatology Research Foundation for a resident research preceptorship – "Genetic and Environmental Susceptibility to Interstitial Lung Disease in Rheumatoid Arthritis."<\/p>\n

Ellen Kerns,<\/b> pediatrics-child health, received a grant of $10,000 from the American Academy of Pediatrics for a consulting services contract.<\/p>\n

Lindsey Page,<\/b> neurological sciences, received a grant of $4,969 from the American College of Sports Medicine for a prospective study of the effects of androgen deprivation therapy on neurocognition and frailty in prostate cancer.<\/p>\n

Poonam Velagapudi, MD,<\/b> internal medicine-cardiovascular, revied a grant of $1,330 from the Icahn School of Medicine at Mount Sinai for a hybrid coronary revascularization trial.<\/p>\n

Industry-sponsored grants and contracts:<\/b><\/p>\n

The following industry-sponsored contracts and foundation grants were received. Information on clinical trials enrolling patients at UNMC can be found here<\/a>.<\/b><\/p>\n

Rana Zabad, MD,<\/b> neurological sciences, received funding for a phase 3, randomized, double-blind, efficacy and safety study comparing SAR442168 to placebo in participants with primary progressive multiple sclerosis and a phase 3, randomized, double-blind efficacy and safety study comparing SAR442168 to teriflunomide (Aubagio) in participants with relapsing forms of multiple sclerosis.<\/p>\n

Kelsey Klute, MD,<\/b> internal medicine-oncology\/hematology, received funding for a phase 3, randomized, double-blind Study of pamrevlumab or placebo in combination with Gemcitabine Plus Nab-paclitaxel as neoadjuvant treatment in patients with locally advanced, unresectable pancreatic cancer (LAPIS).<\/p>\n

William Rizzo, MD,<\/b> pediatrics metabolism, received funding for assay development and screening for discovery of inhibitors of ALDH3A2 as novel therapeutics for treatment of acute myeloid leukemia.<\/p>\n

Julie Vose, MD,<\/b> internal medicine-oncology\/hematology, received funding for a phase 1B\/3 double-blind, randomized, active-controlled, 3-stage, biomarker adaptive study of Tazemetostat or placebo in combination with Lenalidomide plus Rituximab in subjects with relapsed\/refractory follicular lymphoma.<\/p>\n

Alexander Hewlett, DO,<\/b> internal medicine-GI, received funding for a phase 3, multi-center, multi-national, randomized, double-blind, placebo-controlled induction and maintenance study to evaluate the efficacy and safety of CC-93538 In adult and adolescent subjects with eosinophilic esophagitis.<\/p>\n

Kari Simonsen, MD,<\/b> received funding for a phase-3 open label dose-finding study to evaluate safety, tolerability and immunogenicity and phase 2\/3 placebo-controlled, observer-blinded safety, tolerability and immunogenicity study of a SARS-COV-2 RNA vaccine.<\/p>\n

David F. Mercer, MD, PhD,<\/b> surgery-transplant, received funding for a multicenter, double-blinded, randomized, placebo-controlled trial to evaluate the efficacy and safety of apraglutide in adult subjects with short bowel and intestinal failure.<\/p>\n

Cyrus Desouza, MBBS,<\/b> internal medicine-DEM, received funding to study the effect of semaglutide in subjects with non-cirrhotic non-alcoholic steatohepatitis.<\/p>\n

Sarah Holstein, MD, PhD,<\/b> internal medicine-oncology\/hematology, received funding for a phase II study of Lenalidomide, Ixazomib, Dexamethasone and Daratumumab in transplant-ineligible patients with newly diagnosed multiple myeloma.<\/p>\n

Lori Harris, MD,<\/b> internal medicine-oncology\/hematology, received funding for an open-label, multi-center phase 2 clinical trial evaluating SNS-301 in patients with ASPH+ high risk myelodysplastic syndrome and chronic myelomonocytic leukemia.<\/p>\n

Carol Toris, PhD,<\/b> ophthalmology and visual sciences, received funding for a work order: Aqueous humor dynamics. Dr. Toris also received funding for a T-Rex outflow facility assessment.<\/p>\n

Trevor Van Schooneveld, MD,<\/b> internal medicine-infectious diseases, received funding for a pneumonia panel with stewardship review impact on antibiotic use.<\/p>\n

Michael Baine, MD, PhD,<\/b> radiation oncology, received funding for associating adiponectin signaling with chronic toxicity following pelvic radiation.<\/p>\n

Jamie Wilson, MD,<\/b> neurosurgery, received funding for a phase 2, randomized, double-blind, placebo-controlled study to assess the efficacy and safety of MT-3921 in subjects with acute traumatic cervical spinal cord injury.<\/p>\n

Whitney Goldner, MD,<\/b> internal medicine-DEM, received funding for specimen collection for Siemens thyroid assays\/Atellica IM Thyroblogulin (tg) Assay.<\/p>\n

Diana Florescu, MD,<\/b> internal medicine-infectious diseases, received funding for a retrospective study to collect follow-up data at 12 months among transplant recipients with refractory or resistant cytomegalovirus infections randomized to the Maribavir treatment arm in the SHP620-303 open-label phase III trial.<\/p>\n<\/a><\/div><\/div>","protected":false},"excerpt":{"rendered":"

The UNMC College of Medicine received grant and funding awards representing $11,037,387 in new funding in June.<\/p>\n","protected":false},"author":27,"featured_media":71577,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_relevanssi_hide_post":"","_relevanssi_hide_content":"","_relevanssi_pin_for_all":"","_relevanssi_pin_keywords":"","_relevanssi_unpin_keywords":"","_relevanssi_related_keywords":"","_relevanssi_related_include_ids":"","_relevanssi_related_exclude_ids":"","_relevanssi_related_no_append":"","_relevanssi_related_not_related":"","_relevanssi_related_posts":"","_relevanssi_noindex_reason":"","footnotes":""},"categories":[1],"tags":[],"class_list":["post-71576","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-uncategorized","department-anesthesiology","department-biochemistry-and-molecular-biology","department-cellular-and-integrative-physiology","department-college-of-medicine","department-emergency-medicine","department-genetics-cell-biology-and-anatomy","department-intercom","department-internal-medicine","department-neurological-sciences","department-neurosurgery","department-obstetrics-and-gynecology","department-ophthalmology-and-visual-sciences","department-orthopaedic-surgery-and-rehabilitation","department-otolaryngology-head-and-neck-surgery","department-pathology-and-microbiology","department-pharmacology-and-experimental-neuroscience","department-radiation-oncology","department-surgery"],"yoast_head":"\nResearch 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