{"id":71987,"date":"2021-10-26T00:00:00","date_gmt":"2021-10-26T05:00:00","guid":{"rendered":"https:\/\/www.unmc.edu\/newsroom\/2021\/10\/26\/research-highlights-86\/"},"modified":"2022-08-29T14:15:26","modified_gmt":"2022-08-29T19:15:26","slug":"research-highlights-86","status":"publish","type":"post","link":"https:\/\/www.unmc.edu\/newsroom\/2021\/10\/26\/research-highlights-86\/","title":{"rendered":"Research highlights"},"content":{"rendered":"

The UNMC College of Medicine received grant and funding awards representing $9.3 million in new funding in August.<\/p>\n

Howard Fox, MD, PhD,<\/b> neurological sciences, received a grant of $1,417,351 from the SHHS\/NIH\/NIDA for a study uncovering HIV\/opioid effects in the brain at the single cell level.<\/p>\n

Jill Poole, MD,<\/b> internal medicine-allergy\/immunology, received a grant of $545,912 from DHHS\/CDC\/NIOSH for a study on resolving occupational exposure-induced lung disease.<\/p>\n

Iqbal Javeed, PhD, <\/b>pathology\/microbiology, received a grant of $500,778 from DHHS\/NIH\/NCI for a study on the Cooperative role of TET2 & IDH2 mutation in angioimmunoblastic T-cell lymphomageneis.<\/p>\n

Jyoti Kaushal, PhD,<\/b> biochemistry and molecular biology, received a grant of $462,500 from the U.S. Army\/USAMRAA\/CDMRP to study the regulatory mechanism of non-canonical hedgehog signaling and its association with autophagy in castration resistant prostate cancer.<\/p>\n

Anna Dunaevsky, PhD,<\/b> neurological sciences, received a grant of $434,385 from DHHS\/NIH\/NINDS for developing an astroglial model for Fragile X Syndrome.<\/p>\n

Karsten Bartels, MD, PhD,<\/b> anesthesiology, received a grant of $399,429 from DHHS\/AHQR, for a study on efficiency and quality in post-surgical pain therapy after discharge.<\/p>\n

Shannon Buckley-McKeown, PhD,<\/b> genetics, cell biology and anatomy, received a grant of  $385,386 from  DHHS\/NIH\/NIAID to study the role of E3 ligase UBR5 in alternative splicing during B cell development and activation. Dr. Buckley-McKeown also received a grant of $385,301 from DHHS\/NIH\/NCI for dissecting the role of ubiquitin E3 ligase UBR5 in lymphomagenesis.<\/p>\n

Ying Yan, PhD,<\/b> radiation oncology, received a grant of $306,167 from DHHS\/NIH\/NIGMS to study PR55-alpha controlled PP2A in the regulation of the Hippo\/YAP pathway.<\/p>\n

William Rizzo, MD,<\/b> pediatrics-metabolism, received a grant of $223,198 from DHHS\/NIH\/NICHD for a study defining ichthyosis in Sjogren-Larsson syndrome for clinical trial preparedness.<\/p>\n

Howard Gendelman, MD,<\/b> pharmacology and experimental neuroscience, received a grant of $53,552 from the Icahn School of Medicine at Mt. Sinai to study single cell brain transcriptome changes during chronic HIV infection and opiate use in conventional mice.<\/p>\n

Matthew Garlinghouse, PhD,<\/b> neurological sciences, revied a grant of $48,204 from the City University of New York-Brooklyn College for a novel multimodal assessment of practical judgment across the Alzheimer's continuum: Toward a better understanding of how to predict risk in the elderly.<\/p>\n

Juan Santamaria, MD,<\/b> surgery-surgical oncology, revied a grant of $25,000 from the John Wayne Cancer Foundation for increasing Latinx breast cancer clinical trial participation through patient navigation.<\/p>\n

Melissa Cullimore, MD, PhD, <\/b>pediatrics-critical care, received a grant $14,553 from the Research Institute at Nationwide Children’s Hospital for pediatric research of drugs, immunoparalysis and genetics during MODS.<\/p>\n

Kelly Stauch, PhD,<\/b> neurological sciences, received a grant of $7,500 from the Nebraska Bankers Association for Seahorse Core equipment.<\/p>\n

Joseph Americo Fernandes, MD,<\/b> neurological sciences, received a grant of $1,870 from Columbia University for a PLS natural history study.<\/p>\n

Industry-sponsored grants and contracts:<\/b><\/p>\n

The following industry-sponsored contracts and foundation grants were received. Information on clinical trials enrolling patients at UNMC can be found here<\/a>.<\/a><\/b><\/p>\n

Avyakta Kallam, MBBS,<\/b> internal medicine-oncology\/hematology, received funding for an open-label extension study evaluating the long-term safety and efficacy of orali of GB002 for the treatment of WHO Group 1 pulmonary arterial hypertension.<\/p>\n

Kerry Rodabaugh, MD,<\/b> internal medicine-oncology\/hematology, received funding for a phase 1, multicenter, open-label, dose escalation and dose expansion study of SQZ-PBMC-HPV as monotherapy and in combination with Atezolizumab in HLA-A*02+ patients with HPV16+ recurrent, locally advanced or metastatic solid tumors.<\/p>\n

Daniel Murman, MD,<\/b> neurological sciences, received funding for an open-label, multicenter rollover study to evaluate the safety, tolerability and efficacy of long-term gantenerumab administration in participants with Alzheimer’s.<\/p>\n

Tammy Wichman, MD,<\/b> internal medicine-pulmonary, received funding for a phase 2\/3, multicenter, randomized, double-blind, placebo-controlled, adaptive design study to evaluate the efficacy and safety of MK-5475 in adults with pulmonary arterial hypertension and for a phase 3 study to compare the efficacy and safety of Sotatercept vs. placebo when added to background pulmonary arterial hypertension therapy.<\/p>\n

David F. Mercer, MD, PhD,<\/b> surgery-transplant, received funding for a phase 3 extension trial investigating the safety and efficacy of Glepaglutide in adult patients with short bowel syndrome completing the EASE SBS 2 trial.<\/p>\n

Daniel Hershberger, MD,<\/b> internal medicine-pulmonary, received funding for a Phase 3 trial to evaluate the efficacy and safety of PRM-151 in patients with idiopathic pulmonary fibrosis.<\/p>\n

Apar Ganti, MD,<\/b> internal medicine-oncology\/hematology, received funding for a Phase 1\/2 trial of MRTX849 in patients with advanced solid tumors with KRAS G12C mutation.<\/p>\n

Vishal Kothari, MD,<\/b> surgery-general surgery, received funding for a prophylactic reinforcement of ventral abdominal incisions trial: Prospective trial of Phasix mesh to prevent incisional hernia subsequent to open midline laparotomy.<\/p>\n

John Davis, PhD,<\/b> obstetrics\/gynecology, received a grant of $45,000 from Colorado State University, for a study showing ISGs in the corpus luteum are necessary for maintenance of pregnancy in ruminants.<\/p>\n

James McClay, MD,<\/b> emergency medicine, received a grant of $44,801 from Duke University for HERO: Healthcare Worker Exposure Response and Outcomes.<\/p>\n

Alissa Marr, MD,<\/b> internal medicine-oncology\/hematology, received funding for a study to compare adjuvant immunotherapy of Bempegaldesleukin combined with nivolumab vs. nivolumab after complete resection of melanoma in patients at high risk for recurrence.<\/p>\n

Ronald Zolty, MD, PhD,<\/b> internal medicine-cardiovascular, received funding for the Riociguat Users Registry.<\/p>\n

Richard Starlin, MD,<\/b> internal medicine-infectious diseases, received funding for a study to evaluate the efficacy and safety of an amikacin liposome inhalation suspension-based regimen.<\/p>\n

Muhamed Baljevic, MD,<\/b> internal medicine-oncology\/hematology, received funding for an expanded access protocol for subjects receiving Idecabtagene Vicleucel that is nonconforming for commercial release.<\/p>\n

Andrew Goldsweig, MD,<\/b> internal medicine-cardiovasular, received funding for a study of paravalvular leak closure with the Amplatzer Valvular Plus Occluder for interventional transcatheter closure for PVL with surgical biological and mechanical heart valve.<\/p>\n

Nicholas Woods, PhD,<\/b> pathology\/microbiology, received a grant of $36,297from DHHS\/NIH\/NIAID for a study on elucidation of the role of chlamydial ClpX during development and differentiation.<\/p>\n

Joshua Santarpia, PhD,<\/b> pathology\/microbiology, received funding for a study on metal-organic frameworks for the inactivation of viral bioaerosols in public spaces.<\/p>\n

e odQjK <\/a><\/div><\/div><\/div>","protected":false},"excerpt":{"rendered":"

The UNMC College of Medicine received grant and funding awards representing $9.3 million in new funding in 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