{"id":72247,"date":"2021-11-24T00:00:00","date_gmt":"2021-11-24T06:00:00","guid":{"rendered":"https:\/\/www.unmc.edu\/newsroom\/2021\/11\/24\/research-highlights-87\/"},"modified":"2022-08-29T14:17:14","modified_gmt":"2022-08-29T19:17:14","slug":"research-highlights-87","status":"publish","type":"post","link":"https:\/\/www.unmc.edu\/newsroom\/2021\/11\/24\/research-highlights-87\/","title":{"rendered":"Research highlights"},"content":{"rendered":"

The UNMC College of Medicine received grant and funding awards representing $15.1 million in new funding in September.<\/span><\/p>\n

Matthew Rizzo, MD,<\/span><\/b> neurological sciences, received a Great Plains IDeA-CTR – Cycle 2 grant for $4,299,998 from DHHS\/NIH\/NIGMS.<\/span><\/p>\n

Jill Poole, MD,<\/span><\/b> internal medicine-allergy\/immunology, received a grant of $2,084,290 from U.S. Army\/USAMRAA\/CDMRP.<\/span><\/p>\n

Ted Mikuls, MD,<\/span><\/b> internal medicine-rheumatology, received a grant of $1,003,276 from U.S. Army\/USAMRAA\/CDMRP for a study of dynamic interaction of airborne biohazards in rheumatoid arthritis-associated lung disease.<\/span><\/p>\n

Leah Cook, PhD<\/span><\/b>, pathology\/microbiology, received a grant of $926,248 from U.S. Army\/USAMRAA\/CDMRP for a study of therapeutic targeting of Nox2 to target bone metastatic prostate cancer progression and immune evasion.<\/span><\/p>\n

Ying Yan, PhD,<\/span><\/b> radiation oncology, received a grant of $655, 076 from U.S. Army\/USAMRAA\/CDMRP for a study of effective oral benzimidazole carbamates for the treatment of metastatic breast cancer.<\/span><\/p>\n

Kaushik Patel, PhD,<\/span><\/b> cellular and integrative physiology, received a grant of $510,235 from DHHS\/NIH\/NIDDK for a study of a novel target mechanism (renal nerves) for the beneficial actions of SGLT2 inhibition in congestive heart failure.<\/span><\/p>\n

Paul Sorgen, PhD,<\/span><\/b> biochemistry and molecular biology, received a grant of $496,349 from DHHS\/NIH\/NIGMS for a study on mechanisms of gap junction regulation.<\/span><\/p>\n

Jingwei Xie, PhD,<\/span><\/b> surgery-transplant, received a grant of $340,836 from DHHS\/NIH\/NIGMS for a study of nanofiber-based delivery of combined immune-modulating compounds to minimize infection and enhance wound healing.<\/span><\/p>\n

Aaron Barksdale, MD,<\/span><\/b> emergency medicine, received a grant of$255,241 from Vanderbilt University Medical Center for a study of novel experimental COVID therapies affecting host response, connects master protocol for clinical trials targeting macro-micro-immuno-thromobsis, vascular hyperinflammation, and hypercoagulability and renin-angiotensin-aldoesterone system.<\/span><\/p>\n

Micah Schott, PhD,<\/span><\/b> biochemistry and molecular biology, received a grant of $249,000 from DHHS\/NIH\/NIAAA to study the synergy of lipolysis and lipophagy in alcoholic liver disease.<\/span><\/p>\n

Jae Hyuk Yoo, PhD,<\/span><\/b> ophthalmology and visual sciences, received a grant of $246,879 from DHHS\/NIH\/NCI for a study on ARF6 function in cancers driven by RAS hyperactivation.<\/span><\/p>\n

Matthew Halanski, MD,<\/b> orthopaedic surgery, received a grant of $215,131 from DHHS\/NIH\/NIAMS for a study on improving spinal growth modulation using a novel kyphotic porcine model.<\/span><\/p>\n

Aditya Bade, PhD,<\/b> pharmacology and experimental neuroscience, received a grant of $191,355 from DHHS\/NIH\/NICHD for a study of the functional mechanism underlying Dolutegravir (DTG)-associated developmental CNS abnormalities: Inhibition of matrix metalloproteinases activities.<\/span><\/p>\n

Jamie Wilson, MD,<\/b> neurosurgery, received a grant of $173,520 from the University of British Columbia for The Canadian-American Spinal Cord Perfusion Pressure and Biomarker Study – CASPER.<\/span><\/p>\n

Vimla Band, PhD,<\/span><\/b> genetics, cell biology and anatomy, received a grant of $76,542 from DHHS\/NIH\/NCI for a study of the co-oncogenic role of ECD in HER2-driven breast cancer.<\/span><\/p>\n

Kendra Clark, PhD,<\/span><\/b> obstetrics\/gynecology, received a grant of $65,994 from DHHS\/NIH\/NICHD for a study on the roles of hippo signaling and gap junctional communication in follicle development.<\/span><\/p>\n

Chengfeng Bi, MD, PhD,<\/span><\/b> pathology\/microbiology, received two grants of $63,464 and $58,541 from the Roswell Park Cancer Institute for studies on the therapeutic effect of eFT-226 and Onvasertib in hematological patient-derived xenograft models and synthetic reoaglates as promising the therapeutic agents for aggressive hematological malignancies.<\/span><\/p>\n

Amy Cannella, MD,<\/span><\/b> internal medicine-rheumatology, received the FY 2023 Rheumatology Research Foundation Amgen Fellowship Training Award of $50,000 from the Rheumatology Research Foundation.<\/span><\/p>\n

Nathan Hatch,<\/span><\/b> pathology and microbiology, received a grant of $36,297 from NHHS\/NIH\/NIAID for a study defining the persistence associated transcriptome in chlamydia trachomatis. <\/span><\/p>\n

Melissa Cullimore, MD, PhD,<\/span><\/b> pediatrics-critical care, received a grant of $18,960 from Boston’s Children’s Hospital for a study on understanding COVID-19 among critically ill children in PALISI Network.<\/span><\/p>\n

Jean Ballweg, MD,<\/span><\/b> pediatrics-cardiology, received a grant of $10,534 from Johns Hopkins University for a data science approach to identify and manage Multisystem Inflammatory Syndrome in Children (MIS-C) associated with SARS-CoV-2 infection and Kawasaki disease in pediatric patients.<\/span><\/p>\n

Industry-sponsored grants and contracts:<\/span><\/b><\/p>\n

The following industry-sponsored contracts and foundation grants were received.<\/span><\/p>\n

Roslyn Mannon, MD,<\/span><\/b> internal medicine-nephrology, received funding for a study on the validation of genomic immune-phenotyping profiles to predict risk of kidney transplant rejection.<\/span><\/p>\n

Andre Kalil, MD,<\/span><\/b> internal medicine-infectious diseases, received funding for a multicenter platform trial of putative therapeutics for the treatment of COVID-19 in hospitalized adults.<\/span><\/p>\n

Benjamin Teply, MD,<\/span><\/b> internal medicine-oncology\/hematology, received funding for a phase 3, multicenter, double-blind, randomized, placebo-controlled trial of Infigratinib for the adjuvant treatment of subjects with invasive urothelial carcinoma with susceptible FGFR3 genetic alterations.<\/span><\/p>\n

Robert Bociek, MD,<\/span><\/b> internal medicine-oncology\/hematology, received funding for a study of acalabrutinib in combination with rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) in Subjects 65 years with previously untreated non-germinal center.<\/span><\/p>\n

David F. Mercer, MD,<\/span><\/b> surgery-transplant, received funding for a study on living with short bowel syndrome (SBS): impact on child and family wellbeing and quality of life.<\/span><\/p>\n

Siddappa Byrareddy, PhD,<\/span><\/b> pharmacology and experimental neuroscience, received funding for determination of SARS-CoV-2 aerosol removal and destruction efficacy of Photoelectrochemical Oxidative Filter-Based Air Purification Unit.<\/span><\/p>\n

Lauren Edwards, MD,<\/span><\/b> psychiatry, received funding for a study of the Empower Neuromodulation System, a home-use device for the treatment of anxiety disorders.<\/span><\/p>\n

Sachit Patel, MD,<\/span><\/b> pediatrics-hematology\/oncology, received funding for a study on real-world treatment patterns and outcomes in patients with hemophagocytic lymphohistiocytosis (HLH) and other clinical conditions treated with emapalumab across treatment centers in the U.S.<\/span><\/p>\n

Daniel Murman, MD,<\/span><\/b> neurological sciences, received funding for an exploratory study to quantify health care use among Medicare-enrolled patients participating in phase 3 clinical trails on Alzheimer’s disease.<\/span><\/p>\n<\/div><\/div>","protected":false},"excerpt":{"rendered":"

The UNMC College of Medicine received grant and funding awards representing $15.1 million in new funding in September.<\/p>\n","protected":false},"author":27,"featured_media":70179,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_relevanssi_hide_post":"","_relevanssi_hide_content":"","_relevanssi_pin_for_all":"","_relevanssi_pin_keywords":"","_relevanssi_unpin_keywords":"","_relevanssi_related_keywords":"","_relevanssi_related_include_ids":"","_relevanssi_related_exclude_ids":"","_relevanssi_related_no_append":"","_relevanssi_related_not_related":"","_relevanssi_related_posts":"","_relevanssi_noindex_reason":"","footnotes":""},"categories":[1],"tags":[],"class_list":["post-72247","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-uncategorized","topic-inside-unmc","topic-research","department-biochemistry-and-molecular-biology","department-cellular-and-integrative-physiology","department-college-of-medicine","department-emergency-medicine","department-genetics-cell-biology-and-anatomy","department-intercom","department-internal-medicine","department-neurological-sciences","department-neurosurgery","department-obstetrics-and-gynecology","department-ophthalmology-and-visual-sciences","department-orthopaedic-surgery-and-rehabilitation","department-pathology-and-microbiology","department-pediatrics","department-pharmacology-and-experimental-neuroscience","department-psychiatry","department-radiation-oncology","department-surgery"],"yoast_head":"\nResearch 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