{"id":72425,"date":"2021-12-22T00:00:00","date_gmt":"2021-12-22T06:00:00","guid":{"rendered":"https:\/\/www.unmc.edu\/newsroom\/2021\/12\/22\/research-highlights-88\/"},"modified":"2022-08-29T14:18:07","modified_gmt":"2022-08-29T19:18:07","slug":"research-highlights-88","status":"publish","type":"post","link":"https:\/\/www.unmc.edu\/newsroom\/2021\/12\/22\/research-highlights-88\/","title":{"rendered":"Research highlights"},"content":{"rendered":"

The UNMC College of Medicine received grant and funding awards representing approximately $5.6 million in new funding in October and November.<\/p>\n

Paul Fey, PhD,<\/b> pathology\/microbiology, received a grant of $650,969 from the DHS\/NIH\/NIAID to study mechanisms of staphylococcal skin colonization.<\/p>\n

Steven Yeh, MD,<\/b> ophthalmology and visual sciences, received a grant of $623,030 from DHHS\/NIH\/NEI to study the pathogenesis of uveitis in Ebola virus disease survivors. Dr. Yeh also received a grant of $45,000 from the ARVO Foundation for Eye Research for a pathogenesis of herpetic retinitis clinical and immunology assessment. He also received a grant of $19,670 from the Macula Society for ophthalmic surveillance of emerging infectious diseases within sub-Saharan African and southeast Asian outbreak zones.<\/p>\n

Carol Casey, PhD,<\/b> internal medicine-GI, received a grant of $531,819 from DHHS\/NIH\/NIAAA to study the altered lipid droplet trafficking role in alcoholic fatty liver disease. She also received a grant of $13,701 from the University of Nebraska-Lincoln for the Nebraska Center for the Prevention of Obesity Diseases through Dietary Molecules.<\/p>\n

Iqbal Javeed, PhD,<\/b> pathology\/microbiology, received a grant of $301,146 from DHHS\/NIH\/NCI to study pre-analytical variables of bioanalytes affecting the accuracy of PTCL diagnostic and prognostic genetic signatures.<\/p>\n

James Murphy, MD,<\/b> internal medicine-pulmonary, received a grant of $203,151 from the Seattle Children’s Research Institute for a prospective study to evaluate maternal and fetal outcomes in the era of modulators. Dr. Murphy also received funding for a  study of the safety and pharmacokinetics of AR-501.<\/p>\n

Thuy Koll, MD,<\/b> internal medicine-geriatrics, received a grant of $190,188 from DHHS\/NIH\/NIA for promoting physical activity to improve cognitive function in older adults undergoing hematopoietic cell transplantation.<\/p>\n

Nadia Pare, PhD,<\/b> neurological sciences, received a grant of $181,023 from the City University of New York-Brooklyn College for a novel multimodal assessment of practical judgment across the Alzheimer's continuum: Toward a better understanding of how to predict risk in the elderly.<\/p>\n

Ann Anderson Berry, MD, PhD,<\/b> pediatrics-newborn medicine, received at grant of $127,499 from Harvard College for the Health's Early Roots & Origins (HERO) Program.<\/p>\n

Nora Sarvetnick, PhD,<\/b> surgery-transplant, received a grant of $100,000 from the Cincinnati Children’s Hospital Medical Center to study gene regulation as a foundation for autoimmune disease prevention.<\/p>\n

Jingwei Xie, PhD,<\/b> surgery-transplant, received a grant of $95,341 from the Glebe Medical Research Foundation to study 3D nanofiber scaffolds for effective craniomaxillofacial bone regeneration.<\/p>\n

Vijay Shivaswamy, MBBS,<\/b> internal medicine-DEM, received multiple grants, including a grant of $85,781 from the Nebraska Educational Biomedical Research Association as an ICA in the Ramesh Ramalingam-prominent study at VA; a grant of $22,772 from the Nebraska Educational Biomedical Research Association as an ICA for Payton Hurlburt; a grant of $40,186 from the Nebraska Educational Biomedical Research Association as an ICA for Jenna Egbert; a grant of $24,781 from the Nebraska Educational Biomedical Research Association as an ICA for Adam Hornig; and a grant of $16,100 from the Nebraska Educational Biomedical Research Association as an ICA for Katelyn Kelley.<\/p>\n

Kelsey Klute, MD,<\/b> internal medicine-oncology\/hematology, received a grant of $56,000 from the Mayo Clinic for a study of gemcitabine and cisplatin with AG120 or pemigatinib for advanced cholangiocarcinoma.<\/p>\n

Cyrus Desouza, MBBS,<\/b> internal medicine-DEM, received multiple grants, including a grant of $49,619 from the Nebraska Educational Biomedical Research Association as an ICA for the SURPASS study; a grant of $31,914 from George Washington University for "Continuation of Glycemic Reduction Approaches in Diabetes: A Comparative Effectiveness Study"; a grant of $22,772 from the Nebraska Educational Biomedical Research Association as an ICA for Payton Hurlburt; a grant of $65,697 from the Nebraska Educational Biomedical Research Association as an ICA for Lisa Keuchenmeister; and a grant of $42,890 from the Nebraska Educational Biomedical Research Association as an ICA for Ramesh Ramalingam.<\/p>\n

Matthew Lunning, DO,<\/b> internal medicine-oncology\/hematology, received a grant of $37,159 from Pennsylvania State University for a study on a single conical tube device for precision CAR-T cells manufacturing.<\/p>\n

Karsten Bartels, MD, PhD,<\/b> anesthesiology, received a grant of $10,000 from DHHS\/NIH\/NHLBI to study cardiovascular outcomes research in perioperative medicine.<\/p>\n

Bracha Goldsweig, MD,<\/b> pediatrics-endocrine, received a grant of $7.501 from the University of South Florida for a TrialNet Clinic agreement.<\/p>\n

Andrew Dudley, PhD,<\/b> genetics, cell biology and anatomy, received a $6,000 NASA Nebraska Space Grant for a FY22 fellowship.<\/p>\n

Travis McCumber, PhD,<\/b> genetics, cell biology and anatomy, received a $5,000 NASA Nebraska Space Grant to study the effect of femoral neck geometry on bone microstructure.<\/p>\n

Industry-sponsored grants and contracts:<\/b><\/p>\n

The following industry-sponsored contracts and foundation grants were received.<\/p>\n

David F. Mercer, MD, PhD,<\/b> surgery-transplant, received funding for a study of the efficacy, safety and tolerability of NM-002 in adult patients with short bowel syndrome.  <\/p>\n

Diana Florescu, MD,<\/b> internal medicine-infectious diseases, received funding for a study to evaluate the efficacy and safety of MK-4482 for the prevention of COVID-19. Dr. Florescu also received funding for a study of the safety and tolerability of intravenous brincidofovir in subjects with adenovirus infection.<\/p>\n

Fedja Rochling, MD,<\/b> internal medicine-GI, received funding for a study to evaluate the efficacy and safety of linerixibat for the treatment of cholestatic pruritus in participants with primary biliary cholangitis.<\/p>\n

Casey Burg, MD,<\/b> pediatrics-pulmonary, received funding for a study to evaluate the safety and efficacy of pitolisant in patients with Prader-Willi syndrome, followed by an open-label extension.<\/p>\n

Sara Bares, MD,<\/b> internal medicine-infectious diseases, received funding for a study to assess the efficacy, safety, tolerability, and resistance profile of GSK3640254 in combination with dolutegravir compared to dolutegravir plus lamivudine.<\/p>\n

Rana Zabad, MD,<\/b> neurological sciences, received funding for a trial of the efficacy and safety of nabiximols oromucosal spray as add-on therapy in patients with spasticity due to multiple sclerosis.<\/p>\n

Jean Grem, MD,<\/b> internal medicine-oncology\/hematology, received funding for a study of the safety and pharmacokinetics of fixed-dose PCS6422 with escalating doses of capecitabine administered orally to patients with advanced, refractory gastrointestinal tract tumors.<\/p>\n

Diego Torres-Russotto, MD,<\/b> neurological sciences, received funding for a trial with an open-label period to investigate the efficacy and safety of NT 201 in the unilateral and bilateral treatment of essential tremor of the upper limb.<\/p>\n

Dr. Desouza<\/b> also received funding for an efficacy and safety investigation of NNC0194-0499 co-administered with semaglutide in subjects with non-alcoholic steatohepatitis: a dose-ranging, placebo-controlled trial; to study the effects of ziltivekimab versus placebo on cardiovascular outcomes in patients with established atherosclerotic cardiovascular disease, chronic kidney disease and systemic inflammation; to study dose response and safety of an oral PCSK9i, NNC0385-0434, in patients with very high or high cardiovascular risk on maximally tolerated statin treatment requiring further LDL-C reduction.<\/p>\n

Apar Ganti, MD,<\/b> internal medicine-oncology\/hematology, received funding for a study of autologous tumor infiltrating lymphocytes (LN-145) in patients with metastatic non-small-cell lung cancer.<\/p>\n

Scott Westphal, MD,<\/b> internal medicine-nephrology, received funding for a study of SARS-CoV-2 mRNA-1273 vaccine in adult solid organ transplant recipients and healthy controls.<\/p>\n<\/div><\/div>","protected":false},"excerpt":{"rendered":"

The UNMC College of Medicine received grant and funding awards representing approximately $5.6 million in new funding in October and November.<\/p>\n","protected":false},"author":27,"featured_media":72426,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_relevanssi_hide_post":"","_relevanssi_hide_content":"","_relevanssi_pin_for_all":"","_relevanssi_pin_keywords":"","_relevanssi_unpin_keywords":"","_relevanssi_related_keywords":"","_relevanssi_related_include_ids":"","_relevanssi_related_exclude_ids":"","_relevanssi_related_no_append":"","_relevanssi_related_not_related":"","_relevanssi_related_posts":"","_relevanssi_noindex_reason":"","footnotes":""},"categories":[1],"tags":[],"class_list":["post-72425","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-uncategorized","topic-research","department-anesthesiology","department-college-of-medicine","department-genetics-cell-biology-and-anatomy","department-intercom","department-internal-medicine","department-neurological-sciences","department-ophthalmology-and-visual-sciences","department-pathology-and-microbiology","department-pediatrics","department-surgery"],"yoast_head":"\nResearch 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