{"id":95291,"date":"2023-01-17T15:03:00","date_gmt":"2023-01-17T21:03:00","guid":{"rendered":"https:\/\/www.unmc.edu\/newsroom\/?p=95291"},"modified":"2023-01-18T18:11:45","modified_gmt":"2023-01-19T00:11:45","slug":"unmc-teams-exploring-possibility-of-extended-release-covid-vaccine","status":"publish","type":"post","link":"https:\/\/www.unmc.edu\/newsroom\/2023\/01\/17\/unmc-teams-exploring-possibility-of-extended-release-covid-vaccine\/","title":{"rendered":"UNMC teams exploring extended-release COVID vaccine"},"content":{"rendered":"<div class=\"panel body-content\"><div class=\"panel__container\">\n<p>&nbsp;A team of UNMC researchers developed a novel delivery platform for a \u201cnext generation\u201d COVID vaccine. The vaccine is delivered through controlled, biodegradable, stable polymeric microspheres that permit the viral antigen to be released slowly over extended time periods to reduce the need for repeated boosters.&nbsp;<\/p>\n\n\n\n<p>The paper, <a href=\"https:\/\/doi.org\/10.1016\/j.actbio.2022.12.043\" target=\"_blank\" rel=\"noreferrer noopener\">published in Acta Biomaterialia<\/a>, details the creation of the biodegradable polymeric microsphere. Proof of concept was tested with chemically inactivated SARS-CoV-2 proteins carried within the delivery formulation. These viral proteins, when encapsulated in the polymeric microspheres, induced robust antiviral immunity in animal models.<\/p>\n\n\n\n<p>The viral antigen-loaded microsphere system can prevent the need for repeat immunizations, highlighting its potential as a unique vaccine delivery mechanism. \u201cThe idea of a single vaccine for SARS-CoV-2 without boosting can be realized if and when viral evolution can be accurately predicted,\u201d said Howard Gendelman, MD, co-corresponding author of the paper and chair of the UNMC Department of Pharmacology and Experimental Neuroscience (PEN). \u201cCOVID is certainly going to be with us for quite a long time.\u201d<\/p>\n\n\n\n<p>Although still in an early stage, the study shows a path to predictive antiviral immunity through the development of a unique delivery system that could carry multiple viral antigens. \u201cThe new vaccine would serve to ameliorate the acquisition-based fatigue being seen in response to the frequent boosters needed to address SARS-CoV-2 virus evolution\u201d said Bhavesh Kevadiya, PhD, co-corresponding author and a prior assistant professor in the PEN department.<\/p>\n\n\n\n<p>The PEN department maintains itself as a world leader in the development, characterization and translation of long-acting drugs and vaccines for the treatment and prevention of viral diseases.<\/p>\n\n\n\n<p>\u201cWe are in the beginning stages,\u201d said Farah Shahjin, PhD, lead author and a former graduate student in PEN. \u201cBut we have a lot of options to move this forward. These approaches are the future of ameliorating the severity of COVID in the times ahead.\u201d<\/p>\n\n\n\n<p>The work served to demonstrate proof-of-concept for the successful loading and potential immunogenic responses to the whole, inactive SARS-CoV-2 virus-loaded microsphere. These results, in turn, offer the possibilities of future studies to optimize the process parameters to generate microsphere-borne viral antigens, as well as a long-term study of the immune responses against the antigen of interest, and therefore could provide the opportunity for developing a long-acting vaccine.<\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"alignright size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"400\" height=\"300\" src=\"https:\/\/www.unmc.edu\/newsroom\/wp-content\/uploads\/2023\/01\/HasanMilankumar.jpg\" alt=\"\" class=\"wp-image-95293\" srcset=\"https:\/\/www.unmc.edu\/newsroom\/wp-content\/uploads\/2023\/01\/HasanMilankumar.jpg 400w, https:\/\/www.unmc.edu\/newsroom\/wp-content\/uploads\/2023\/01\/HasanMilankumar-300x225.jpg 300w\" sizes=\"auto, (max-width: 400px) 100vw, 400px\" \/><figcaption class=\"wp-element-caption\">From left, UNMC student researchers Mahmudul Hasan and Milankumar Patel <\/figcaption><\/figure>\n<\/div>\n\n\n<p>\u201cThe virus mutates. If we work to predict the mutations over a period of three or four years, we can plug that into a single vaccine. We can then use this system to deliver the vaccine formulated for the new, mutated virus we predict over a longer period of time, staying ahead of the virus and not reacting to it,\u201d said Dr. Gendelman.<\/p>\n\n\n\n<p>The study\u2019s authors, which include current PEN graduate students Mahmudul Hasan and Milankumar Patel, posit that these injectable biodegradable polymers represent a means for the sustained release of emerging viral antigens. \u201cThe approach offers a means to reduce immunization frequency by predicting viral genomic variability,\u201d the paper says. \u201cThis strategy could lead to longer-lasting antiviral protective immunity.\u201d<\/p>\n\n\n\n<p>The success in vaccine development follows a broader COVID vaccine initiative involving a novel modular vaccine platform through chemically synthesized peptides and bioinformatic target data, such as another study \u2014 by the teams of UNMC scientists led by Yuri Lyubchenko PhD, DSc, professor in pharmaceutical sciences, and Siddappa Byrareddy, PhD, professor and vice chair of research in PEN as co-corresponding authors \u2014 <a href=\"https:\/\/doi.org\/10.1016\/j.nano.2022.102604\" target=\"_blank\" rel=\"noreferrer noopener\">published in the journal Nanomedicine<\/a>. \u201cThis second vaccine study is based on immunogen design that contains two defined B-cell epitopes from the spike glycoprotein of SARS-CoV-2 and the universal T-helper epitope PADRE,\u201d said Dr. Byrareddy. In this study, the immunogens used were formulated by conjugation to gold nanoparticles, which elicited an IgG immune response and generated high virus-neutralizing titers.<\/p>\n\n\n\n<p>A <a href=\"https:\/\/www.azonano.com\/news.aspx?newsID=38639\" target=\"_blank\" rel=\"noreferrer noopener\">reviewer of the online publication summarized<\/a>: \u201cThe translation of this well-targeted epitope vaccine, which can be highly accessible and affordable, enables protection with minimal stimulation of the immune system;&nbsp;this research could be revolutionary, not only for the COVID-19 pandemic and the variants of concern associated with this highly transmissible virus but also for all types of vaccines.\u201d<\/p>\n\n\n\n<p>The two studies taken together demonstrate the versatility of methods for future SARS-CoV-2&nbsp;immune protection, although additional research still will need to be done before there is an application to humans.<\/p>\n<\/div><\/div>","protected":false},"excerpt":{"rendered":"<p>Studies show proof-of-concept for new viral antigen delivery system.<\/p>\n","protected":false},"author":27,"featured_media":95292,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_relevanssi_hide_post":"","_relevanssi_hide_content":"","_relevanssi_pin_for_all":"","_relevanssi_pin_keywords":"","_relevanssi_unpin_keywords":"","_relevanssi_related_keywords":"","_relevanssi_related_include_ids":"","_relevanssi_related_exclude_ids":"","_relevanssi_related_no_append":"","_relevanssi_related_not_related":"","_relevanssi_related_posts":"61485,70794,62302,48141,40155,50229","_relevanssi_noindex_reason":"","footnotes":""},"categories":[1],"tags":[],"class_list":["post-95291","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-uncategorized","topic-inside-unmc","topic-research","department-college-of-medicine","department-covid-19","department-pharmacology-and-experimental-neuroscience","department-unmc-today-todays-headlines","author_override-john-keenan-unmc-strategic-communications"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>UNMC teams exploring extended-release COVID vaccine<\/title>\n<meta name=\"description\" content=\"Studies show proof-of-concept for new viral antigen delivery system.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.unmc.edu\/newsroom\/2023\/01\/17\/unmc-teams-exploring-possibility-of-extended-release-covid-vaccine\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"UNMC teams exploring extended-release COVID vaccine\" \/>\n<meta property=\"og:description\" content=\"Studies show proof-of-concept for new viral antigen delivery system.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.unmc.edu\/newsroom\/2023\/01\/17\/unmc-teams-exploring-possibility-of-extended-release-covid-vaccine\/\" \/>\n<meta property=\"og:site_name\" content=\"Newsroom\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/unmcedu\" \/>\n<meta property=\"article:published_time\" content=\"2023-01-17T21:03:00+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2023-01-19T00:11:45+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.unmc.edu\/newsroom\/wp-content\/uploads\/2023\/01\/KevFarGend.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"900\" \/>\n\t<meta property=\"og:image:height\" content=\"600\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"John Keenan\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@unmc\" \/>\n<meta name=\"twitter:site\" content=\"@unmc\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"John Keenan\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"4 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/www.unmc.edu\\\/newsroom\\\/2023\\\/01\\\/17\\\/unmc-teams-exploring-possibility-of-extended-release-covid-vaccine\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.unmc.edu\\\/newsroom\\\/2023\\\/01\\\/17\\\/unmc-teams-exploring-possibility-of-extended-release-covid-vaccine\\\/\"},\"author\":{\"name\":\"John Keenan\",\"@id\":\"https:\\\/\\\/www.unmc.edu\\\/newsroom\\\/#\\\/schema\\\/person\\\/59c9598a54f1a531c30cccc1d010ac17\"},\"headline\":\"UNMC teams exploring extended-release COVID vaccine\",\"datePublished\":\"2023-01-17T21:03:00+00:00\",\"dateModified\":\"2023-01-19T00:11:45+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/www.unmc.edu\\\/newsroom\\\/2023\\\/01\\\/17\\\/unmc-teams-exploring-possibility-of-extended-release-covid-vaccine\\\/\"},\"wordCount\":726,\"commentCount\":5,\"publisher\":{\"@id\":\"https:\\\/\\\/www.unmc.edu\\\/newsroom\\\/#organization\"},\"image\":{\"@id\":\"https:\\\/\\\/www.unmc.edu\\\/newsroom\\\/2023\\\/01\\\/17\\\/unmc-teams-exploring-possibility-of-extended-release-covid-vaccine\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/www.unmc.edu\\\/newsroom\\\/wp-content\\\/uploads\\\/2023\\\/01\\\/KevFarGend.jpg\",\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\\\/\\\/www.unmc.edu\\\/newsroom\\\/2023\\\/01\\\/17\\\/unmc-teams-exploring-possibility-of-extended-release-covid-vaccine\\\/#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.unmc.edu\\\/newsroom\\\/2023\\\/01\\\/17\\\/unmc-teams-exploring-possibility-of-extended-release-covid-vaccine\\\/\",\"url\":\"https:\\\/\\\/www.unmc.edu\\\/newsroom\\\/2023\\\/01\\\/17\\\/unmc-teams-exploring-possibility-of-extended-release-covid-vaccine\\\/\",\"name\":\"UNMC teams exploring extended-release COVID vaccine\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.unmc.edu\\\/newsroom\\\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\\\/\\\/www.unmc.edu\\\/newsroom\\\/2023\\\/01\\\/17\\\/unmc-teams-exploring-possibility-of-extended-release-covid-vaccine\\\/#primaryimage\"},\"image\":{\"@id\":\"https:\\\/\\\/www.unmc.edu\\\/newsroom\\\/2023\\\/01\\\/17\\\/unmc-teams-exploring-possibility-of-extended-release-covid-vaccine\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/www.unmc.edu\\\/newsroom\\\/wp-content\\\/uploads\\\/2023\\\/01\\\/KevFarGend.jpg\",\"datePublished\":\"2023-01-17T21:03:00+00:00\",\"dateModified\":\"2023-01-19T00:11:45+00:00\",\"description\":\"Studies show proof-of-concept for new viral antigen delivery system.\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/www.unmc.edu\\\/newsroom\\\/2023\\\/01\\\/17\\\/unmc-teams-exploring-possibility-of-extended-release-covid-vaccine\\\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/www.unmc.edu\\\/newsroom\\\/2023\\\/01\\\/17\\\/unmc-teams-exploring-possibility-of-extended-release-covid-vaccine\\\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/www.unmc.edu\\\/newsroom\\\/2023\\\/01\\\/17\\\/unmc-teams-exploring-possibility-of-extended-release-covid-vaccine\\\/#primaryimage\",\"url\":\"https:\\\/\\\/www.unmc.edu\\\/newsroom\\\/wp-content\\\/uploads\\\/2023\\\/01\\\/KevFarGend.jpg\",\"contentUrl\":\"https:\\\/\\\/www.unmc.edu\\\/newsroom\\\/wp-content\\\/uploads\\\/2023\\\/01\\\/KevFarGend.jpg\",\"width\":900,\"height\":600,\"caption\":\"Howard Gendelman, M.D., during a press conference to announce that through a collaborative effort, researchers at the University of Nebraska Medical Center and the Lewis Katz School of Medicine at Temple University have, for the first time, eliminated replication-competent HIV-1 DNA \u2013 the virus responsible for AIDS \u2013 from the genomes of living animals. The press conference was held in the Durham Research Center commons area on the UNMC campus in Omaha on Wednesday, July 3, 2019.\"},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/www.unmc.edu\\\/newsroom\\\/2023\\\/01\\\/17\\\/unmc-teams-exploring-possibility-of-extended-release-covid-vaccine\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\\\/\\\/www.unmc.edu\\\/newsroom\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"UNMC teams exploring extended-release COVID vaccine\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/www.unmc.edu\\\/newsroom\\\/#website\",\"url\":\"https:\\\/\\\/www.unmc.edu\\\/newsroom\\\/\",\"name\":\"Newsroom\",\"description\":\"\",\"publisher\":{\"@id\":\"https:\\\/\\\/www.unmc.edu\\\/newsroom\\\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/www.unmc.edu\\\/newsroom\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Organization\",\"@id\":\"https:\\\/\\\/www.unmc.edu\\\/newsroom\\\/#organization\",\"name\":\"University of Nebraska Medical Center\",\"url\":\"https:\\\/\\\/www.unmc.edu\\\/newsroom\\\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/www.unmc.edu\\\/newsroom\\\/#\\\/schema\\\/logo\\\/image\\\/\",\"url\":\"https:\\\/\\\/www.unmc.edu\\\/newsroom\\\/wp-content\\\/uploads\\\/2022\\\/08\\\/overview-1.png\",\"contentUrl\":\"https:\\\/\\\/www.unmc.edu\\\/newsroom\\\/wp-content\\\/uploads\\\/2022\\\/08\\\/overview-1.png\",\"width\":500,\"height\":153,\"caption\":\"University of Nebraska Medical Center\"},\"image\":{\"@id\":\"https:\\\/\\\/www.unmc.edu\\\/newsroom\\\/#\\\/schema\\\/logo\\\/image\\\/\"},\"sameAs\":[\"https:\\\/\\\/www.facebook.com\\\/unmcedu\",\"https:\\\/\\\/x.com\\\/unmc\",\"https:\\\/\\\/instagram.com\\\/iamunmc\",\"https:\\\/\\\/www.youtube.com\\\/user\\\/UNMCEDU\"]},{\"@type\":\"Person\",\"@id\":\"https:\\\/\\\/www.unmc.edu\\\/newsroom\\\/#\\\/schema\\\/person\\\/59c9598a54f1a531c30cccc1d010ac17\",\"name\":\"John Keenan\",\"url\":\"https:\\\/\\\/www.unmc.edu\\\/newsroom\\\/author\\\/02e74f10e0327ad868d138f2b4fdd6f0\\\/\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"UNMC teams exploring extended-release COVID vaccine","description":"Studies show proof-of-concept for new viral antigen delivery system.","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.unmc.edu\/newsroom\/2023\/01\/17\/unmc-teams-exploring-possibility-of-extended-release-covid-vaccine\/","og_locale":"en_US","og_type":"article","og_title":"UNMC teams exploring extended-release COVID vaccine","og_description":"Studies show proof-of-concept for new viral antigen delivery system.","og_url":"https:\/\/www.unmc.edu\/newsroom\/2023\/01\/17\/unmc-teams-exploring-possibility-of-extended-release-covid-vaccine\/","og_site_name":"Newsroom","article_publisher":"https:\/\/www.facebook.com\/unmcedu","article_published_time":"2023-01-17T21:03:00+00:00","article_modified_time":"2023-01-19T00:11:45+00:00","og_image":[{"width":900,"height":600,"url":"https:\/\/www.unmc.edu\/newsroom\/wp-content\/uploads\/2023\/01\/KevFarGend.jpg","type":"image\/jpeg"}],"author":"John Keenan","twitter_card":"summary_large_image","twitter_creator":"@unmc","twitter_site":"@unmc","twitter_misc":{"Written by":"John Keenan","Est. reading time":"4 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/www.unmc.edu\/newsroom\/2023\/01\/17\/unmc-teams-exploring-possibility-of-extended-release-covid-vaccine\/#article","isPartOf":{"@id":"https:\/\/www.unmc.edu\/newsroom\/2023\/01\/17\/unmc-teams-exploring-possibility-of-extended-release-covid-vaccine\/"},"author":{"name":"John Keenan","@id":"https:\/\/www.unmc.edu\/newsroom\/#\/schema\/person\/59c9598a54f1a531c30cccc1d010ac17"},"headline":"UNMC teams exploring extended-release COVID vaccine","datePublished":"2023-01-17T21:03:00+00:00","dateModified":"2023-01-19T00:11:45+00:00","mainEntityOfPage":{"@id":"https:\/\/www.unmc.edu\/newsroom\/2023\/01\/17\/unmc-teams-exploring-possibility-of-extended-release-covid-vaccine\/"},"wordCount":726,"commentCount":5,"publisher":{"@id":"https:\/\/www.unmc.edu\/newsroom\/#organization"},"image":{"@id":"https:\/\/www.unmc.edu\/newsroom\/2023\/01\/17\/unmc-teams-exploring-possibility-of-extended-release-covid-vaccine\/#primaryimage"},"thumbnailUrl":"https:\/\/www.unmc.edu\/newsroom\/wp-content\/uploads\/2023\/01\/KevFarGend.jpg","inLanguage":"en-US","potentialAction":[{"@type":"CommentAction","name":"Comment","target":["https:\/\/www.unmc.edu\/newsroom\/2023\/01\/17\/unmc-teams-exploring-possibility-of-extended-release-covid-vaccine\/#respond"]}]},{"@type":"WebPage","@id":"https:\/\/www.unmc.edu\/newsroom\/2023\/01\/17\/unmc-teams-exploring-possibility-of-extended-release-covid-vaccine\/","url":"https:\/\/www.unmc.edu\/newsroom\/2023\/01\/17\/unmc-teams-exploring-possibility-of-extended-release-covid-vaccine\/","name":"UNMC teams exploring extended-release COVID vaccine","isPartOf":{"@id":"https:\/\/www.unmc.edu\/newsroom\/#website"},"primaryImageOfPage":{"@id":"https:\/\/www.unmc.edu\/newsroom\/2023\/01\/17\/unmc-teams-exploring-possibility-of-extended-release-covid-vaccine\/#primaryimage"},"image":{"@id":"https:\/\/www.unmc.edu\/newsroom\/2023\/01\/17\/unmc-teams-exploring-possibility-of-extended-release-covid-vaccine\/#primaryimage"},"thumbnailUrl":"https:\/\/www.unmc.edu\/newsroom\/wp-content\/uploads\/2023\/01\/KevFarGend.jpg","datePublished":"2023-01-17T21:03:00+00:00","dateModified":"2023-01-19T00:11:45+00:00","description":"Studies show proof-of-concept for new viral antigen delivery system.","breadcrumb":{"@id":"https:\/\/www.unmc.edu\/newsroom\/2023\/01\/17\/unmc-teams-exploring-possibility-of-extended-release-covid-vaccine\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.unmc.edu\/newsroom\/2023\/01\/17\/unmc-teams-exploring-possibility-of-extended-release-covid-vaccine\/"]}]},{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/www.unmc.edu\/newsroom\/2023\/01\/17\/unmc-teams-exploring-possibility-of-extended-release-covid-vaccine\/#primaryimage","url":"https:\/\/www.unmc.edu\/newsroom\/wp-content\/uploads\/2023\/01\/KevFarGend.jpg","contentUrl":"https:\/\/www.unmc.edu\/newsroom\/wp-content\/uploads\/2023\/01\/KevFarGend.jpg","width":900,"height":600,"caption":"Howard Gendelman, M.D., during a press conference to announce that through a collaborative effort, researchers at the University of Nebraska Medical Center and the Lewis Katz School of Medicine at Temple University have, for the first time, eliminated replication-competent HIV-1 DNA \u2013 the virus responsible for AIDS \u2013 from the genomes of living animals. The press conference was held in the Durham Research Center commons area on the UNMC campus in Omaha on Wednesday, July 3, 2019."},{"@type":"BreadcrumbList","@id":"https:\/\/www.unmc.edu\/newsroom\/2023\/01\/17\/unmc-teams-exploring-possibility-of-extended-release-covid-vaccine\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/www.unmc.edu\/newsroom\/"},{"@type":"ListItem","position":2,"name":"UNMC teams exploring extended-release COVID vaccine"}]},{"@type":"WebSite","@id":"https:\/\/www.unmc.edu\/newsroom\/#website","url":"https:\/\/www.unmc.edu\/newsroom\/","name":"Newsroom","description":"","publisher":{"@id":"https:\/\/www.unmc.edu\/newsroom\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/www.unmc.edu\/newsroom\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Organization","@id":"https:\/\/www.unmc.edu\/newsroom\/#organization","name":"University of Nebraska Medical Center","url":"https:\/\/www.unmc.edu\/newsroom\/","logo":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/www.unmc.edu\/newsroom\/#\/schema\/logo\/image\/","url":"https:\/\/www.unmc.edu\/newsroom\/wp-content\/uploads\/2022\/08\/overview-1.png","contentUrl":"https:\/\/www.unmc.edu\/newsroom\/wp-content\/uploads\/2022\/08\/overview-1.png","width":500,"height":153,"caption":"University of Nebraska Medical Center"},"image":{"@id":"https:\/\/www.unmc.edu\/newsroom\/#\/schema\/logo\/image\/"},"sameAs":["https:\/\/www.facebook.com\/unmcedu","https:\/\/x.com\/unmc","https:\/\/instagram.com\/iamunmc","https:\/\/www.youtube.com\/user\/UNMCEDU"]},{"@type":"Person","@id":"https:\/\/www.unmc.edu\/newsroom\/#\/schema\/person\/59c9598a54f1a531c30cccc1d010ac17","name":"John Keenan","url":"https:\/\/www.unmc.edu\/newsroom\/author\/02e74f10e0327ad868d138f2b4fdd6f0\/"}]}},"_links":{"self":[{"href":"https:\/\/www.unmc.edu\/newsroom\/wp-json\/wp\/v2\/posts\/95291","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.unmc.edu\/newsroom\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.unmc.edu\/newsroom\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.unmc.edu\/newsroom\/wp-json\/wp\/v2\/users\/27"}],"replies":[{"embeddable":true,"href":"https:\/\/www.unmc.edu\/newsroom\/wp-json\/wp\/v2\/comments?post=95291"}],"version-history":[{"count":6,"href":"https:\/\/www.unmc.edu\/newsroom\/wp-json\/wp\/v2\/posts\/95291\/revisions"}],"predecessor-version":[{"id":95388,"href":"https:\/\/www.unmc.edu\/newsroom\/wp-json\/wp\/v2\/posts\/95291\/revisions\/95388"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.unmc.edu\/newsroom\/wp-json\/wp\/v2\/media\/95292"}],"wp:attachment":[{"href":"https:\/\/www.unmc.edu\/newsroom\/wp-json\/wp\/v2\/media?parent=95291"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.unmc.edu\/newsroom\/wp-json\/wp\/v2\/categories?post=95291"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.unmc.edu\/newsroom\/wp-json\/wp\/v2\/tags?post=95291"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}