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PAUL FEY, PhD EDUCATION |
RESEARCH INTEREST
Investigators in our laboratory address questions related to acquisition of nutrients, specifically secondary carbon and nitrogen sources, and their link to expression of virulence factors within specific niches of the host. Current studies are centered in understanding amino acid and peptide catabolism, but can extend to a variety of compounds. Recent published studies have identified major pathways that S. aureus utilizes to catabolize amino acids, but larger questions exist regarding whether staphylococcal proteases cleave specific proteins at the site of infection to gain access to these nutrients. Other studies in the laboratory are investigating questions related to colonization of various staphylococcal species on the surface of the skin. What is their function and how do they survive? Is species diversity important? Is the mechanism of adherence to the skin surface conserved across all staphylococcal species? Our laboratory and the Center for Staphylococcal Research is highly collaborative and gives pre- and post-doctoral trainees opportunities for travel to study in various laboratories worldwide.
REPRESENTATIVE PUBLICATIONS
- R. Galac, J. Stam, R. Maybank, M. Hinkle, D. Mack, H. Rohde, A. L. Roth, and P. D. Fey. 2017. Complete genome sequence of Staphylococcus epidermidis1457. Genome Announce. 5(22)
- T. Marolf, R. Alter, E. Lyden, P.D. Fey, M.E. Rupp. 2017. Susceptibility of Nosocomial Staphylococcus aureusto chlorhexidine after implementation of a hospital-wide antiseptic bathing regimen. Infect Control Hosp Epidemiol. 5:1-3. doi: 10.1017/ice.2017.80.
- C. Thomas and P.D. Fey. 2017. Biofilms: Take my breath away. eLife; 6:324739
- Cawcutt, K., P.D. Fey, and A.C. Kalil. 2017. Respiratory Pathogen Panels in the Hospital: Good or Unnecessary? Curr Opin Infect Dis. 30:226-230
- Cortney R. Halsey, Shulei Lei, Jacqueline Wax, McKenzie K. Lehman, Austin S. Nuxoll, Laurey Steinke, Marat Sadykov, Robert Powers, and Paul D Fey. 2017. Amino acid catabolism in Staphylococcus aureusand the function of carbon catabolite repression. mBio 2017 Feb 14;8(1).
- Alexandra E. Paharik, Marta Kotasinska, Henning Büttner, Anna Both, Tra-My Hoang, Paroma Roy, Paul D. Fey, Alexander R. Horswill, and Holger Rohde. 2017. The metalloprotease SepA governs processing of accumulation-associated protein and shapes intercellular adhesive surface properties in Staphylococcus epidermidis. Mol Microbiol 103(5):860-874
- N Murphy, R. C. Fowler, P. C. Iwen, and P. D. Fey. 2016. Evaluation of the BioFire FilmArray® Gastrointestinal Panel in a Midwestern Academic Hospital. Eur J Clin Microbiol Infect Dis. Epub ahead of print
- R. Schaeffer, Tra-My N. Hoang, C. M. Sudbeck, M. Alawi, I. E. Tolo, D. A. Robinson, A. R. Horswill, H. Rohde, and P.D. Fey. 2016. Versatility of biofilm matrix molecules in Staphylococcus epidermidisclinical isolates and importance of polysaccharide intercellular adhesin (PIA) expression during high shear stress. mSphere Oct 5;1(5). pii: e00165-16 PMID: 27747298
- Andre C. Kalil, Mark L. Metersky, Michael Klompas, John Muscedere, Daniel A. Sweeney, Lucy B. Palmer, Lena M. Napolitano, Naomi P. O'Grady, John G.Bartlett, Jordi Carratal, Ali A. El Solh, Santiago Ewig, Paul D. Fey, Thomas M. File, Jr., Marcos I. Restrepo, Jason A. Roberts, Grant W. Waterer, Peggy Cruise, MLIS, Shandra Protzko, MLIS, and Jan L. Brozek. 2016. Executive Summary: Management of Adults with Hospital-acquired and Ventilator-associated Pneumonia: 2016 Clinical Practice Guidelines by the Infectious Diseases Society of America and the American Thoracic Society. Clin Infect Dis 63(5):575-828 doi: 10.1093/cid/ciw504.
- Sarah Rowe, Christopher Campbell, Colm Lowry, Sinead O'Donnell, Michael Olson, Jill Lindgren, Elaine Waters, Paul D Fey, and James O'Gara. 2016. AraC-type regulator Rbf controls the Staphylococcus epidermidisbiofilm phenotype by negatively regulating the icaADBC repressor SarR. J. Bacteriol. 198:2914-2924. PMID: 27521441
- Andre C. Kalil, Mark L. Metersky, Michael Klompas, John Muscedere, Daniel A. Sweeney, Lucy B. Palmer, Lena M. Napolitano, Naomi P. O'Grady, John G. Bartlett, Jordi Carratalà, Ali A. El Solh, Santiago Ewig, Paul D. Fey, Thomas M. File, Jr. Marcos I. Restrepo, Jason A. Roberts, Grant W. Waterer, Peggy Cruise, MLIS, Shandra Protzko, MLIS, and Jan L. Brozek. 2016. Management of Adults with Hospital-acquired and Ventilator-associated Pneumonia: 2016 Clinical Practice Guidelines by the Infectious Diseases Society of America and the American Thoracic Society. Clin Infect Dis.63(5):e61-e111 doi: 10.1093/cid/ciw353
- International Typhoid Consortium, Wong VK, Holt KE, Okoro C, Baker S, Pickard DJ, Marks F, Page AJ, Olanipekun G, Munir H, Alter R, Fey PD, Feasey NA, Weill FX, Le Hello S, Hart PJ, Kariuki S, Breiman RF, Gordon MA, Heyderman RS, Jacobs J, Lunguya O, Msefula C, MacLennan CA, Keddy KH, Smith AM, Onsare RS, De Pinna E, Nair S, Amos B, Dougan G, Obaro S. 2016. Molecular Surveillance Identifies Multiple Transmissions of Typhoid in West Africa. PLoS Negl Trop Dis Sep 22;10(9):e0004781. doi: 10.1371/journal.pntd.0004781.
- McCarthy, E. Waters, J. Bose, S. Foster, K. Bayles, E. O'Neill, P.D. Fey, J. P. O'Gara. 2016. The major autolysin is redundant for Staphylococcus aureusUSA300 LAC JE2 virulence in a murine device-related infection model. FEMS Microbiol Lett 363(9). pii: fnw087. doi: 10.1093/femsle/fnw087.
- K. Yajjala, V.C. Thomas, C. Bauer, T.D. Scherr, P.D. Fey, K.W. Bayles, T. Kielian, and K. Sun. 2016. Resistance to Macrophage killing promotes airway fitness of prevalent community-acquired S. aureusstrains. J Immunol 15;196(10):4196-203. doi: 10.4049/jimmunol.1600081.