Tammy Kielian, PhD

TAMMY KIELIAN, PhD
Professor

EDUCATION
BS, University of Nebraska - Lincoln
PhD, University of Kansas Medical Center
Postdoctoral training, Dartmouth Medical School

 

 

RESEARCH INTEREST

Areas of interest include immunometabolism and how S. aureus biofilm-leukocyte metabolic crosstalk influences the epigenetic landscape of leukocytes to promote their anti-inflammatory attributes. We have recently determined that biofilm-associated monocytes are biased towards oxidative phosphorylation that leads to their anti-inflammatory bias and that metabolic reprogramming can augment their pro-inflammatory properties and biofilm clearance. Our recent study has identified a critical role for biofilm metabolism in influencing the anti-inflammatory properties of biofilm-associated leukocytes. This is through the action of S. aureus-derived lactate, which inhibits histone deacetylase 11 (HDAC11) activity and causes extensive epigenetic changes at the promoters of numerous host genes, including the key anti-inflammatory cytokine Il-10.

REPRESENTATIVE PUBLICATIONS (Trainees in bold text)