Rajini Reddy Mudhasani, Ph.D.

Department Affiliations
Assistant Professor

Identification of critical host factors regulating virus pathogenesis.

Education and Training
B.Sc, Osmania University, Telangana, India 1993
M.Sc. University of Pune, Pune, India 1996
Ph.D., Cleveland State University , Cleveland, OH 2004
Molecular Medicine Fellowship, Cleveland Clinic Foundation, 2009-2015

2007: scholarship to attend Keystone Symposium meeting on “MicroRNAs and siRNAs: Biological functions and Mechanism” Jan 28 –Feb 2, 2007, Keystone, Colorado.

2002: Best poster award, by the Department of BGES (Biological, Geological and Environmental Sciences), Cleveland State University, OH.

1996-1998: Received Senior Research Fellowship after qualifying the Graduate Aptitude Test for Engineering (GATE-1996 with 97.3 percentile) conducted by the All Indian Institute of Technology (IIT).

1994-1996: Received Meritorious Student Fellowship (120 among 328,000 applicants) by the Department of Biotechnology, Government of India, to pursue M.Sc in Biotechnology for a period of two years.

Recent Publications
Mudhasani R,
Tran JP, Retterer C, Kota KP, Whitehouse CA, Bavari S. Protein Kinase R Degradation Is Essential for Rift Valley Fever Virus Infection and Is Regulated by SKP1-CUL1-F-box (SCF)FBXW11-NSs E3 Ligase. PLoS Pathog. 2016 Feb 2;12(2). PMID: 26837067; PMCID: PMC4737497 

Mudhasani R*, Kota KP*, Retterer C, Tran JP, Tritsch SR, Zamani R, Whitehouse CA, Bavari S. High-content image-based screening of a signal transduction pathway inhibitor small-molecule library against highly pathogenic RNA viruses. * Equal contribution. J Biomol Screen. 2015, in the Special Edition of Infectious Diseases. Jan; 20(1):141-52. PMID: 25342145.

Patursky-Polischuk I, Kasir J, Miloslavski R, Hayouka Z, Hausner-Hanochi M, Stolovich-Rain M, Tsukerman P, Biton M, Mudhasani R, Jones SN, Meyuhas O. Reassessment of the role of TSC, mTORC1 and microRNAs in amino acid-meditated translational control of TOP mRNAs. PLoS One. 2014 Oct 22;9(10). PMID: 25338081; PMCID: PMC4206288.  

Mudhasani R, Kota KP, Retterer C, Tran JP, Whitehouse CA, Bavari S. High content image-based screening of a protease inhibitor library reveals compounds broadly active against Rift Valley fever virus and other highly pathogenic RNA viruses. PLoS Negl Trop Dis. 2014 Aug 21;8(8). PMID: 25144302; PMCID: PMC4140764.

Miloslavski R, Cohen E, Avraham A, Iluz Y, Hayouka Z, Kasir J, Mudhasani R, Jones SN, Cybulski N, Rüegg MA, Larsson O, Gandin V, Rajakumar A, Topisirovic I,  Meyuhas O. Oxygen sufficiency controls TOP mRNA translation via the TSC-Rheb-mTOR pathway in a 4E-BP-independent manner.  J Mol Cell Biol. 2014 Jun;6(3):255-66. PMID: 24627160; PMCID: PMC4034726.