Rajini Reddy Mudhasani, Ph.D.

Department Affiliations
Assistant Professor

Interests
Identification of critical host factors regulating virus pathogenesis.

Education and Training
B.Sc, Osmania University, Telangana, India 1993
M.Sc. University of Pune, Pune, India 1996
Ph.D., Cleveland State University , Cleveland, OH 2004
Molecular Medicine Fellowship, Cleveland Clinic Foundation, 2009-2015

Recent Publications
Selaković Ž, Tran JP, Kota KP, Lazić M, Retterer C, Besh R, Panchal RG, Soloveva V, Sean VA, Jay WB, Pavić A, Verbić T, Vasiljević B, Kuehl K, Duplantier AJ, Bavari S, Mudhasani R*, Šolaja BA*. Second generation of diazachrysenes:Protection of Ebola virus infected mice and mechanism of action. Eur J Med Chem. 2018 Oct 31;162:32-50.28794043; PubMed PMID: 30408747 *Corresponding Author

Mudhasani R, Tran JP, Retterer C, Kota KP, Whitehouse CA, Bavari S. Protein Kinase R Degradation Is Essential for Rift Valley Fever Virus Infection and Is Regulated by SKP1-CUL1-F-box (SCF)FBXW11-NSs E3 Ligase. PLoS Pathog. 2016 Feb 2;12(2). PMID: 26837067; PMCID: PMC4737497 

Mudhasani R*, Kota KP*, Retterer C, Tran JP, Tritsch SR, Zamani R, Whitehouse CA, Bavari S. High-content image-based screening of a signal transduction pathway inhibitor small-molecule library against highly pathogenic RNA viruses. * Equal contribution. J Biomol Screen. 2015, in the Special Edition of Infectious Diseases. Jan; 20(1):141-52. PMID: 25342145.

Patursky-Polischuk I, Kasir J, Miloslavski R, Hayouka Z, Hausner-Hanochi M, Stolovich-Rain M, Tsukerman P, Biton M, Mudhasani R, Jones SN, Meyuhas O. Reassessment of the role of TSC, mTORC1 and microRNAs in amino acid-meditated translational control of TOP mRNAs. PLoS One. 2014 Oct 22;9(10). PMID: 25338081; PMCID: PMC4206288.  

Mudhasani R, Kota KP, Retterer C, Tran JP, Whitehouse CA, Bavari S. High content image-based screening of a protease inhibitor library reveals compounds broadly active against Rift Valley fever virus and other highly pathogenic RNA viruses. PLoS Negl Trop Dis. 2014 Aug 21;8(8). PMID: 25144302; PMCID: PMC4140764.

Miloslavski R, Cohen E, Avraham A, Iluz Y, Hayouka Z, Kasir J, Mudhasani R, Jones SN, Cybulski N, Rüegg MA, Larsson O, Gandin V, Rajakumar A, Topisirovic I,  Meyuhas O. Oxygen sufficiency controls TOP mRNA translation via the TSC-Rheb-mTOR pathway in a 4E-BP-independent manner.  J Mol Cell Biol. 2014 Jun;6(3):255-66. PMID: 24627160; PMCID: PMC4034726.