Alina G. Sofronescu, PhD, MSc

Department Affiliations 
Associate Professor
Medical Director, Clinical Chemistry Laboratory 

Clinical Expertise 
Clinical Chemistry and Toxicology

Professional Interests
Hemoglobinopathies, tumor biomarkers, newborn screening and errors of metabolism, laboratory evaluation of endocrine disease, pre-analytical interferences, drugs of abuse and toxicology. 

Education and Training 
B.Sc, Biochemistry, Cum Laude, "King Al. I Cuza" University, Iasi, Romania, 2001
MSc, Molecular Biology, Department of Physiology, University of Manitoba, Winnipeg, Manitoba, Canada, 2006
PhD, Molecular Biology, Department of Physiology, University of Manitoba, Winnipeg, Manitoba, Canada, 2010
Clinical Chemistry & Toxicology Fellowship, Department of Pathology and Laboratory Medicine, Medical University of South Carolina, Charleston, South Carolina, USA, 2012

Teaching Activities

Director of Clinical Chemistry Rotation
Clinical Chemistry/Laboratory medicine lectures for medical students.

National Activities

Member of the AACC Academy Scientific Shorts Editorial Board
Member of the AACC Publications Core Committee
Member of the Board of Directors and Vice President of the National Registry of the Certified Chemists/Clinical Chemists (NRCC)
Chair of AACC Midwest Section
Fellow of The American Academy of Clinical Biochemistry (FACB) 

Notable Publications

Cathcart S and Sofronescu AG.  "Myeloneuropathy and cytopenias in a patient wearing dentures".  Clin Biochem. 2017 Aug;50(12):733:73.6

Sofronescu AG.  "Ask the expert: Using Biomarkers to Evaluate Traumatic Brain Injury".  Clinical Laboratory Network (CLN), V43, Issue 6, June 2016

Wedel W and Sofronescu AG.  "Transiently Pink-Tinged Serum in a Patient with Multiple Myeloma and Anemia undergoing Lenalidomide treatment".  Am J Clin Pathol. 2015 Aug;144(2):329-32. 

Sofronescu AG.  "CE-HPLC Testing of Hemoglobin A1c for Assessment of Long Term Glycemic Control in Patients with Diabetes Mellitus".  JSM Biochemistry & Molecular Biology. 09/2013;

Schmidt M, Sofronescu AG, Short 8, Nahas Z, Zhu Y.  "Increased prolactin concentrations in a patient with bipolar disorder".  Clin Chem. 2013 Mar;59(3):473-5.

Sofronescu AG, Loebs T, Zhu Y. "Effects of temperature and light on the stability of bilirubin in plasma samples". Clin Chim Acta. 2012 Feb18;413(3-4):463-6. PubMed PMID: 22108388.

Sofronescu AG, Detillieux KA, Cattini PA.  "FGF-16 is a target for adrenergic stimulation through NF-kappaB activation in postnatal cardiac cells and adult mouse heart".  Cardiovasc Res. 2010 Jul 1;87(1):102-10.PubMedPMID: 20097674.

Sofronescu AG, Jin Y, Cattini PA. A myocyte enhancer factor 2 (MEF2) site located in a hypersensitive region of the FGF16 gene locus is required for preferential promoter activity in neonatal cardiac myocytes. DNA Cell Biol. 2008 Apr;27(4):173-82. PubMed PMID: 18260768.