Kaihong Su, Ph.D.

Department Affiliations
Associate Professor

Interests
Immunology, Autoimmune diseases, Autoantibodies, Neutrophils
Please visit Dr. Su's laboratory webpage for details on her research.

Education and Training
B.S., Nankai University (Microbiology), P. R. China, 1990
M.S., Nankai University (Microbiology), P. R. China, 1993
Ph.D., University of Alabama at Birmingham (Cell Biology), Alabama, 1998
Post-doctoral training (Immunology), University of Alabama at Birmingham, Alabama, 1998-2002

National Activities
Member, American Association of Immunologist (2001-)
Peer reviewer, Genes and Immunity (2006-)
Peer reviewer, the Journal of Immunology (2006-)
Scientific Advisory Board, International Academy of Cardiology (2011-)
Member, American College of Rheumatology (2012-)
Organizing Committee, International conference on Clinical and Cellular Immunology (2012-)
Ad-hoc Member, NIH study sections (2013-)
Regular Member, American Heart Association, Basic Science Immunology study section (2014-)

Notable Publications

Li S, Yu Y, Yue Y, Liao H, Xie W, Thai J, Mikuls TR, Thiele GM, Duryee MJ, Sayles H, Payne JB, Klassen LW, O’Dell JR, Zhang Z, and K. Su. 2015 Autoantibodies from single circulating plasmablasts react with citrullinated antigens and Porphyromonas gingivalis in rheumatoid arthritis, Arthritis Rheumatol (in press)

Yu, Y., C.D. Koehn, Y. Yue, S. Li, G.M. Thiele, M.P. Hearth-Holmes, T.R. Mikuls, J.R. O'Dell, L.W. Klassen, Z. Zhang, and K. Su. 2015. Celastrol inhibits inflammatory stimuli-induced neutrophil extracellular trap formation. Current molecular medicine 15:401-410.

Lange, M.D., L. Huang, Y. Yu, S. Li, H. Liao, M. Zemlin, K. Su, and Z. Zhang. 2014. Accumulation of VH Replacement Products in IgH Genes Derived from Autoimmune Diseases and Anti-Viral Responses in Human. Frontiers in immunology 5:345.

Yu, Y., and K. Su. 2013. Neutrophil Extracellular Traps and Systemic Lupus Erythematosus. Journal of clinical & cellular immunology 4. pii: 139.

Liu, J., M.D. Lange, S.Y. Hong, W. Xie, K. Xu, L. Huang, Y. Yu, G.R. Ehrhardt, M. Zemlin, P.D. Burrows, K. Su, R.H. Carter, and Z. Zhang. 2013. Regulation of VH replacement by B cell receptor-mediated signaling in human immature B cells. Journal of immunology 190:5559-5566.

Liao, H., J.T. Guo, M.D. Lange, R. Fan, M. Zemlin, K. Su, Y. Guan, and Z. Zhang. 2013. Contribution of V(H) replacement products to the generation of anti-HIV antibodies. Clinical immunology 146:46-55.

Li, S., Y. Yu, C.D. Koehn, Z. Zhang, and K. Su. 2013. Galectins in the Pathogenesis of Rheumatoid Arthritis. Journal of clinical & cellular immunology 4(5). pii: 1000164.

Liu, J., W. Xie, M.D. Lange, S.Y. Hong, K. Su, and Z. Zhang. 2013. Internalization of B cell receptors in human EU12 muHC(+) immature B cells specifically alters downstream signaling events. BioMed research international 2013:807240.

Li, S., Y. Yu, Y. Yue, Z. Zhang, and K. Su. 2013. Microbial Infection and Rheumatoid Arthritis. Journal of clinical & cellular immunology 4(6). pii: 174.

The FCRL3 -169CT promoter single-nucleotide polymorphism, which is associated with systemic lupus erythematosus in a Japanese population, predicts expression of receptor protein on CD19+B cells. Gibson AW, Li FJ, Wu J, Edberg JC, Su K, Cafardi J, Wiener H, Tiwari H, Kimberly RP, Davis RS. Arthritis Rheum. 2009 Nov;60(11):3510-2. No abstract available.

Immune opsonins modulate BLyS/BAFF release in a receptor-specific fashion. Li X, Su K, Ji C, Szalai AJ, Wu J, Zhang Y, Zhou T, Kimberly RP, Edberg JC. J Immunol. 2008 Jul 15;181(2):1012-8.

Tumor exosomes inhibit differentiation of bone marrow dendritic cells. Yu S, Liu C, Su K, Wang J, Liu Y, Zhang L, Li C, Cong Y, Kimberly R, Grizzle WE, Falkson C, Zhang HG. J Immunol. 2007 Jun 1;178(11):6867-75.

Expression profile of FcgammaRIIb on leukocytes and its dysregulation in systemic lupus erythematosus. Su K, Yang H, Li X, Li X, Gibson AW, Cafardi JM, Zhou T, Edberg JC, Kimberly RP. J Immunol. 2007 Mar 1;178(5):3272-80.

Anti-GD3 monoclonal antibody effects on lymphocytes and antibody-dependent cellular cytotoxicity. Triozzi PL, Shah JJ, Wang WQ, Aldrich W, Edberg JC, Su K, Carlisle R, Conry R, LoBuglio AF, Forero A. Cancer Biother Radiopharm. 2006 Dec;21(6):553-60.

A membrane form of TNF-alpha presented by exosomes delays T cell activation-induced cell death. Zhang HG, Liu C, Su K, Yu S, Zhang L, Zhang S, Wang J, Cao X, Grizzle W, Kimberly RP.J Immunol. 2006 Jun 15;176(12):7385-93. Erratum in: J Immunol. 2006 Aug 1;177(3):2025. Su, Kaihun [corrected to Su, Kaihong].

A promoter haplotype of the immunoreceptor tyrosine-based inhibitory motif-bearing FcgammaRIIb alters receptor expression and associates with autoimmunity. II. Differential binding of GATA4 and Yin-Yang1 transcription factors and correlated receptor expression and function. Su K, Li X, Edberg JC, Wu J, Ferguson P, Kimberly RP. J Immunol. 2004 Jun 1;172(11):7192-9.

A promoter haplotype of the immunoreceptor tyrosine-based inhibitory motif-bearing FcgammaRIIb alters receptor expression and associates with autoimmunity. I. Regulatory FCGR2B polymorphisms and their association with systemic lupus erythematosus. Su K, Wu J, Edberg JC, Li X, Ferguson P, Cooper GS, Langefeld CD, Kimberly RP. J Immunol. 2004 Jun 1;172(11):7186-91.

O-GlcNAc modification is an endogenous inhibitor of the proteasome. Zhang F, Su K, Yang X, Bowe DB, Paterson AJ, Kudlow JE. Cell. 2003 Dec 12;115(6):715-25.

A novel polymorphism in the Fcgamma receptor IIB (CD32B) transmembrane region alters receptor signaling. Li X, Wu J, Carter RH, Edberg JC, Su K, Cooper GS, Kimberly RP. Arthritis Rheum. 2003 Nov;48(11):3242-52.

For a detailed list of publications, click here.