Weiwei Zhang, Ph.D.

Department Affiliations
Assistant Professor
Clinical Genomics Bioinformatics Analyst

Interests
Next generation sequencing, genomic data analysis, clinical informatics, analysis pipeline development

Education and Training
Ph.D. (Bioinformatics), University of Nebraska Medical Center, 2015
M.S. (Mathematics), University of Nebraska at Omaha, 2010
M.S. (Measuring and Testing Techniques and Instruments), Changchun University of Science and Technology, China, 2008
B.S. (Computer Science and Technology), Changchun University, China, 2005

Teaching Activities
PAMM825 Introduction to R programming for Biomedicine
Resident education in NGS

Committee Member
Cheng Wang, Ph.D. student
Stephen Luebker, Ph.D. student

National Activities
Member, Association for molecular pathology
The Open Science Data Cloud Partnerships for International Research and Education at University of Amsterdam Award
High Performance Computing in the Life/Medical Sciences at the Virginia Bioinformatics Institute Award

Notable Publications
Gong Q*, Wang C*, Zhang W*, Iqbal J, Hu Y, Greiner T, Cornish A, Kim J, Rabadan R, Abate F, Wang X, Inghirami G, McKeithan T, Chan WC. Assessment of T-cell receptor repertoire and clonal expansion in peripheral T-cell lymphoma using RNA-seq data. Scientific reports. 2017.

Zheng M*, Perry AM*, Bierman P, Loberiza F, Nasr MR, Szwajcer D, Del Bigio MR, Smith LM, Zhang W, Greiner TC. Frequency of MYD88 and CD79B Mutations, and MGMT Methylation in Primary Central Nervous System Diffuse Large B-cell Lymphoma. Neuropathology. 2017.

Bouska A*, Bi C*, Lone W*, Zhang W, Kedwaii A, Heavican T, Lachel C, Yu J, Ferro RA, Eldorghamy N, Greiner TC, Vose JM, Weisenburger DD, Gascoyne RD, Rosenwald A, Ott G, Campo E, Rimsza LM, Jaffe ES, Braziel RM, Siebert R, Miles RR, Dave S, Reddy A, Delabie J, Staudt LM, Song JY, McKeithan TW, Fu K, Green MR, Chang WC, Iqbal J. Genomic features of High Grade B-cell Lymphoma  with BL Signature Identifies a Potential Therapeutic Target. Blood. 2017.

Bouska A*, Zhang W*, Gong Q*, Iqbal J, Scuto A, Vose J, Ludvigsen M, Fitzgibbon J, Fu K, Weisenburger DD, Greiner TC, Gascoyne RD, Rosenwald A, Ott G, Campo E, Rimsza LM, Delabie J, Jaffe ES, Braziel RM, Connors JM, Wu CI, Staudt LM, D‘Amore F, McKeithan TW, Chan WC. Combined copy number and mutation analysis identifies oncogenic pathways associated with transformation of follicular lymphoma. Leukemia. 2016

Rohr J; Guo S; Huo J; Bouska A; Lachel CM; Li Y; Simone P; Zhang W; Gong Q; Wang C; Cannon A; Rosenwald A; Gascoyne R; Fu K; Greiner TC; Weisenberger DD; Vose J; Staudt L; Xiao W; Berger F; Borgstahl G; Davis S; McKeithan T; Iqbal J; Chan WC. Recurrent activating mutations of CD28 in peripheral T-cell lymphomas. Leukemia. 2015

Wang C; McKeithan TW; Gong Q; Zhang W; Bouska A; Rosenwald A; Gascoyne RD; Wu X; Wang J; Muhammad Z; Jiang B; Rohr J; Cannon A; Steidl C; Fu K; Li Y; Hung S; Weisenberger DD; Greiner TC; Smith L; Ott G; Rogan EG; Staudt LM; Vose J; Iqbal J; Chan WC. IDH2R172 mutations define a unique subgroup of patients with angioimmunoblastic T-cell lymphoma. Blood. Vol. 126 (15): p. 1741-1752, 2015

Kucuk C; Jiang B; Hu X; Zhang W; Chan JK; Xiao W; Lack N; Alkan C; Williams JC; Avery KN; Kavak P; Scuto A; Sen E; Gaulard P; Staudt L; Iqbal J; Zhang W; Cornish A; Gong Q; Yang Q; Sun H; dAmore F; Leppa S; Liu W; Fu K; de Leval L; McKeithan T; Chan WC. Activating mutations of STAT5B and STAT3 in lymphomas derived from Yδ-T or NK cells. Nature Communication. Vol. 6: p. 6025, 2015.

Bouska A; McKeithan TW; Deffenbacher KE; Lachel CM; Wright GW; Iqbal J; Smith LM; Zhang W; Kucuk C; Rinaldi A; Bertoni F; Fitzgibbon J; Fu K; Weisenberger DD; Greiner TC; Dave BJ; Gascoyne RD; Rosenwald A; Ott G; Campo E; Rimsza LM; Delabi J; Jaffe ES; Braziel RM; Connors JM; Staudt LM; Chan WC. Genome-wide copy-number analyses reveal genomic abnormalities involved in transformation of follicular lymphoma. Blood; Vol. 123: p. 1681-1690, 2014.

Guo S; Chan JK; Iqbal J; McKeithan T; Fu K; Meng B; Pan Y; Cheuk W; Luo D; Wang R; Zhang W; Greiner TC; Chan WC. EZH2 mutations in follicular lymphoma from different ethnic groups and associated gene expression alterations. Clinical Cancer Research; Vol. 20: p. 3078-3086, 2014.

Zhang W, Chen W, Wang Z. On the uniqueness of the expression for the choquet integral with linear core in classification. IEEE:769-774, 2009.

Yang R; An Z; Shi L; Cao W; Liu L; Zhang W. Research on modern test system for graduation inclining and image inclining in optical aighting telescope. Chinese J Scientific Instr. 2008

Zhang W; Cao W; Yang R; Duan J. Research on modern testing technology about resolution of telescope system. J Changchun Univ Science Technology. 2007