Ji (Jane) Yuan, M.D., Ph.D.

Department Affiliations
Assistant Professor
Section Medical Director, Flow Cytometry, Hematopathology Laboratory

Interests
Pathology and Hematology

Education and Training
BS, Bachelor of Medicine, Medical Center of Fudan University, Shanghai, China, 1994
MS, Master of Medicine, Medical Center of Fudan University, Shanghai, China, 1999
PhD, University of British Columbia, Vancouver, Canada, 2008

Post Degree Training
Hematopathology Externship, Department of Hematopathology, National Institutes of Health, Bethesda, Maryland, 11/2011 - Present
Hematopathology Fellow, Department of Hematopathology, University of Nebraska Medical Center, Omaha, Nebraska, 2012 - 2013
Chief Resident, Anatomic and Clinical Pathology, Georgia Health Sciences University, Augusta, Georgia, 2011 - 2012
Resident, Department of Pathology, Georgia Health Sciences University, Augusta, Georgia, 2008 - 2011
Resident, Internal Medicine, Shanghai Jiaotong University Affiliated No. 6 Hospital, Shanghai, China, 1999 - 2000
Resident, Internal Medicine, Shanghai Jiaotong University Affiliated No. 6 Hospital, Shanghai, China, 1994 - 1996 

Teaching Activities
Instructor, Department of Hematopathology, University of Nebraska Medical Center, Omaha, NE, 2013 - Present

National Activities
College of American Pathologists
Nebraska Association of Pathologists
American Society for Clinical Pathology
United States and Canadian Academy of Pathology

Notable Publications

Aryal MR, Bhatt VR, Tandra P, Krishnamurthy J, Yuan J, Greiner TC, Akhtari M. Autoimmune neutropenia in multiple myeloma and the role of clonal T-cell expansion: evidence of cross-talk between B-cell and T-cell lineages?. Clin Lymphoma Myeloma Leuk. 14 : e19-23. 2014

Yuan J, Gu K, He J, Sharma S. Preferential up-regulation of osteopontin in primary central nervous system lymphoma does not correlate with putative receptor CD44v6 or CD44H expression. Hum. Pathol. 44 : 606-11. 2013

Yuan J; Manaloor E; Ramalingama P. Hepatosplenic T-cell lymphoma. American Society for Clinical Pathology Check Sample. 2012

Yuan J, Sharma N, Choudhri H, Figueroa R, Sharma S. Intraventricular dysembryoplastic neuroepithelial tumor in a pediatric patient: is it the most common extracortical location for DNT?. Childs Nerv Syst. 27 : 485-90. 2011

Yuan J, McDonough C, Kulharya A, Ramalingam P, Manaloor E. Isolated trisomy 10 in an infant with acute myeloid leukemia: a case report and review of literature. Int J Clin Exp Pathol. 3 : 718-22. 2010

Sall A, Zhang HM, Qiu D, Liu Z, Yuan J, Liu Z, Lim T, Ye X, Marchant D, McManus B, Yang D. Pro-apoptotic activity of mBNIP-21 depends on its BNIP-2 and Cdc42GAP homology (BCH) domain and is enhanced by coxsackievirus B3 infection. Cell. Microbiol. 12 : 599-614. 2010

Yuan J, Shah R, Kulharya A, Ustun C. Near-tetraploidy clone can evolve from a hyperdiploidy clone and cause resistance to lenalidomide and bortezomib in a multiple myeloma patient. Leuk. Res. 34 : 954-7. 2010

Zhang HM, Ye X, Su Y, Yuan J, Liu Z, Stein DA, Yang D. Coxsackievirus B3 infection activates the unfolded protein response and induces apoptosis through downregulation of p58IPK and activation of CHOP and SREBP1. J. Virol. 84 : 8446-59. 2010

Yuan J, Liu Z, Lim T, Zhang H, He J, Walker E, Shier C, Wang Y, Su Y, Sall A, McManus B, Yang D. CXCL10 inhibits viral replication through recruitment of natural killer cells in coxsackievirus B3-induced myocarditis. Circ. Res. 104 : 628-38. 2009

Lim T, Yuan J, Zhang HM, Sall A, Liu Z, Su Y, Yang D. Antisense DNA and RNA agents against picornaviruses. Front. Biosci. 13 : 4707-25. 2008

Sall A, Liu Z, Zhang HM, Yuan J, Lim T, Su Y, Yang D. MicroRNAs-based therapeutic strategy for virally induced diseases. Curr Drug Discov Technol. 5 : 49-58. 2008

Liu Z, Zhang HM, Yuan J, Lim T, Sall A, Taylor GA, Yang D. Focal adhesion kinase mediates the interferon-gamma-inducible GTPase-induced phosphatidylinositol 3-kinase/Akt survival pathway and further initiates a positive feedback loop of NF-kappaB activation. Cell. Microbiol. 10 : 1787-800. 2008

Chau DH, Yuan J, Zhang H, Cheung P, Lim T, Liu Z, Sall A, Yang D. Coxsackievirus B3 proteases 2A and 3C induce apoptotic cell death through mitochondrial injury and cleavage of eIF4GI but not DAP5/p97/NAT1. Apoptosis. 12 : 513-24. 2007

Cheung P, Lim T, Yuan J, Zhang M, Chau D, McManus B, Yang D. Specific interaction of HeLa cell proteins with coxsackievirus B3 3'UTR: La autoantigen binds the 3' and 5'UTR independently of the poly(A) tail. Cell. Microbiol. 9 : 1705-15. 2007

Yuan J; Lim T; Liu Z; Qiu D; Wong B; Luo H; Si X; McManus B; Yang D. Antisense DNA and RNA: Potential Therapeutics for Viral Infection. Anti-Infective Agents in Medicinal Chemistry. 2006; Vol. 5: p. 367-377

Lim TW, Yuan J, Liu Z, Qiu D, Sall A, Yang D. Nucleic-acid-based antiviral agents against positive single-stranded RNA viruses. Curr. Opin. Mol. Ther. 8 : 104-7. 2006

Yuan J, Stein DA, Lim T, Qiu D, Coughlin S, Liu Z, Wang Y, Blouch R, Moulton HM, Iversen PL, Yang D. Inhibition of coxsackievirus B3 in cell cultures and in mice by peptide-conjugated morpholino oligomers targeting the internal ribosome entry site. J. Virol. 80 : 11510-9. 2006

Si X, Luo H, Morgan A, Zhang J, Wong J, Yuan J, Esfandiarei M, Gao G, Cheung C, McManus BM. Stress-activated protein kinases are involved in coxsackievirus B3 viral progeny release. J. Virol. 79 : 13875-81. 2005.

For a detailed list of publications click here.