Research

Each fellow training in the Division of Cardiology will have substantial opportunities to engage in research. Numerous research opportunities exist within and beyond the cardiology faculty. Research training is individualized towards a goal of meeting yet exceeding the requirements for taking the subboard of pediatric cardiology certification examination.  An individualized learning plan with a mentor is developed early in the first year then facilitated and reviewed periodically to ensure achievement. Tools and personnel are available within the Cardiology Division, Department of Pediatrics and College of Medicine to facilitate and support fellows’ research.

Under the American Board of Pediatrics guidelines, a Scholarship Oversight Committee will approve the fellow's scholarly project and then monitor progress achievement. 

Examples of research publications produced by faculty in the Department of Pediatrics are listed on the Pediatrics - Research - Faculty Publications page.

The following are recent research publications produced by faculty in the Division of Cardiology:

Weston C, Husain SA, Curzon CL, Neish K, Kennedy GT, Bonagurio K, Gosselin K. Improving Outcomes for Infants with Single Ventricle Physiology through Standardized Feeding during the Interstage. Nurs Res Pract. 2016;2016:9505629.
 
Kutty S, Rathod RH, Danford DA, Celermajer DS. Role of imaging in the evaluation of single ventricle with the Fontan palliation.  Heart. 2016 Feb 1;102(3):174-83.
 
Kutty SS, Zhang M, Danford DA, Hasan R, Duncan KF, Kugler JD, Quiros-Tejeira RE, Kutty S. Hepatic stiffness in the bidirectional cavopulmonary circulation: The Liver Adult-Pediatric-Congenital-Heart-Disease Dysfunction Study group.  J Thorac Cardiovasc Surg. 2016 Mar;151(3):678-84.
 
Kutty S, Xiao Y, Olson J, Xie F, Danford DA, Erickson CC, Porter TR.  Safety and Efficacy of Cardiac Ultrasound Contrast in Children and Adolescents for Resting and Stress Echocardiography.  J Am Soc Echocardiogr. 2016 Jul;29(7):655-62.
 
Danford DA, Karels Q, Kutty S.  Variabilities in the mortality-related resource utilisation for congenital heart disease.  Open Heart. 2016 May 6;3(1):e000415.
 
Shang Q, Sarikouch S, Patel S, Schuster A, Steinmetz M, Ou P, Danford DA, Beerbaum P, Kutty S.  Assessment of ventriculo-vascular properties in repaired coarctation using cardiac magnetic resonance-derived aortic, left atrial and left ventricular strain.  Eur Radiol. 2017 Jan;27(1):167-177.
 
Kulkarni A, Li L, Craft M, Nanda M, Lorenzo JM, Danford DA, Kutty S.  Fetal Myocardial Deformation in Maternal Diabetes Mellitus and Obesity.  Ultrasound Obstet Gynecol. 2016 May 24.
 
Rush ET, Li L, Goodwin JL, Kreikemeier RM, Craft M, Danford DA, Kutty S.  Echocardiographic phenotype in osteogenesis imperfecta varies with disease severity.  Heart. 2017 Mar;103(6):443-448.
 
Patel SG, Woolman P, Li L, Craft M, Danford DA, Kutty S.  Relation of Right Atrial Volume, Systemic Venous Dimensions, and Flow Patterns to Right Atrial Pressure in Infants and Children. Am J Cardiol. 2017 May 1;119(9):1473-1478.
 
Simpson KE, Storch GA, Lee CK, Ward KE, Danon S, Simon CM, Delaney JW, Tong A, Canter CE. High frequency of Detection by PCR of Viral Nucleic Acid in The Blood of Infants Presenting with Clinical Myocarditis. Pediatr Cardiol. 2016 Feb;37(2):399-404.
 
McElhinney DB, Cabalka AK, Aboulhosn JA, Eicken A, Boudjemline Y, Schubert S, Himbert D, Asnes JD, Salizzoni S, Bocks ML, Cheatham JP, Momenah TS, Kim DW, Schranz D, Meadows J, Thomson JD, Goldstein BH, Crittendon I 3rd, Fagan TE, Webb JG, Horlick E, Delaney JW, Jones TK, Shahanavaz S, Moretti C, Hainstock MR, Kenny DP, Berger F, Rihal CS, Dvir D; VIVID Registry. Transcatheter Tricuspid Valve-in-Valve Implantation for the Treatment of Dysfunctional Surgical Bioprosthetic Valves: An International Multicenter Registry Study. Circulation. 2016 Apr 19;133(16):1582-93.
 
Simpson KE, Cunningham MW, Lee CK, Ward KE, Tong A, Danon S, Simon CM, Delaney JW, Canter CE. Autoimmunity against the heart and cardiac myosin in children with myocarditis. J Card Fail. 2016 Jul;22(7):520-8.
 
Schneider AE, Delaney JW, Cabalka AK. Non-Infectious Thrombosis of the Melody® Valve: A Tale of Two Cities. Catheter Cardiovasc Interv 2016 Jul 20. doi: 10.1002/ccd.26339. [Epub ahead of print]
 
Morray B, McElhinney D, Boudjemline Y, Gewillig M, Kim D, Grant E, Bocks M, Martin M, Armstrong A, Berman D, Danon S, Hoyer M, Delaney JW, Justino H, Qureshi A, Meadows J, Jones T. Multicenter Experience Evaluating Transcatheter Pulmonary Valve Replacement in Bovine Jugular Vein (Contegra) Right Ventricle to Pulmonary Artery Conduits. Circ Cardiovasc Interv. 2017;10:e004914. DOI: 10.1161/CIRCINTERVENTIONS.116.004914.
 
Patel S, Danford DA, Delaney JW. Takotsubo Cardiomyopathy in an Infant. Progress in Pediatric Cardiology – online 6/20/2017.
 
Kutty S, Xiao Y, Olson J, Xie F, Danford DA, Erickson CC, Porter TR. Safety and Efficacy of Cardiac Ultrasound Contrast In Children and Adolescents for Resting and Stress Echocardiography. Journal of the American Society of Echocardiography. 2016 Apr 1. pii: S0894-7317(16)00167-X. doi: 10.1016/j.echo.2016.02.019. [Epub ahead of print].
 
Erickson CC, Salerno J. Looking forward: PACES Task Force on prevention of sudden cardiac death in the young: a comprehensive approach to a preventable problem. Cambridge University Press. 2017:S147-S148. doi:10.1017/S1047951116002407.
 
Erickson CC. Discrimination of the “Athlete’s Heart” from real disease by electrocardiogram and echocardiogram. Cambridge University Press. 2017:S80-S88. doi:10.1017/S1047951116002286.
 
RostonTM, Yuchi Z, Kannankeril PJ, Hathaway J, Vinocur JM, Etheridge SP, Potts JE, Maginot KR, Salerno JC, Cohen MI, Hamilton RM, Pflaumer A, Mohammed S, Kimlicka L, Kanter RM, LaPage MJ, Collins KK, Gebauer RA, Temple JD, Batra AS, Erickson CC, Miszczak-Knecht M, Kubus P, Bar-Cohen Y, Kantock M, Thomas VC, Hessling G, Anderson C, Ming-Lon Y, Choi SHJ, Cabrera Ortega M, Lau YR, Johnsrude CL, Fournier A, Van Petegem F, Sanatani S. The clinical and genetic spectrum of catecholaminergic polymorphic ventricular tachycardia: findings from an international multicenter registry. European Society of Cardiology. Europace (2017) 0, 1-7. Doi:10.1093/europace/euw389.
 
Kulkarni A, Hsu HH, Ou P, Kutty S. Computed Tomography in Congenital Heart Disease:  Clinical Applications and Technical Considerations. Echocardiography. 2016 Apr 1.
 
Harris WS, Kennedy K, Maddox TM, Kutty S, Spertus, JA. Multiple differences between patients who initiate fish oil supplementation post–myocardial infarction and those who do not: the TRIUMPH Study. Nutrition Research. Jan 2016, Volume 36, Issue 1, Pages 65–71.
 
Kulkarni A, Hsu HH, Ou P, Kutty S. Computed Tomography In Congenital Heart Disease: Clinical Applications And Technical Considerations. Echocardiography. 2015 Dec 16.
 
Dreyer RP, Jones PG, Kutty S, Spertus JA. Quantifying clinical change: discrepancies between patients' and providers' perspectives. Qual Life Res. 2016 Mar 19.
 
Schuster A, Hor KN, Kowallick JT, Beerbaum P, Kutty S. Cardiovascular Magnetic Resonance Myocardial Feature Tracking: Concepts and Clinical Applications. Circ Cardiovasc Imaging. 2016 Apr;9(4). pii: e004077.
 
Kutty S, Xiao Y, Olson J, Xie F, Danford DA, Erickson CC, Porter TR. Safety and Efficacy of Cardiac Ultrasound Contrast in Children and Adolescents for Resting and Stress Echocardiography. J Am Soc Echocardiogr. 2016 Apr 1.
 
Cantinotti M, Giordano R, Clemente A, Assanta N, Murzi M, Murzi B, Crocetti M, Marotta M, Scalese M, Kutty S, Iervasi G. Strengths and Limitations of Current Adult Nomograms for the Aorta Obtained by Noninvasive Cardiovascular Imaging. Echocardiography. 2016 Apr 5.
 
Cantinotti M, Giordano R, Scalese M, Murzi B, Assanta N, Spadoni I, Maura C, Marco M, Molinaro S, Kutty S, Iervasi G. Nomograms for two-dimensional echocardiography derived valvular and arterial dimensions in Caucasian children. J Cardiol. 2016 Apr 23.
 
Apers S, Kovacs AH, Luyckx K, Thomet C, Budts W, Enomoto J, Sluman MA, Wang JK, Jackson JL, Khairy P, Cook SC, Chidambarathanu S, Alday L, Eriksen K, Dellborg M, Berghammer M, Mattson E, Mackie AS, Menahem S, Caruana M, Veldtman G, Soufi A, Romfh A, White K, Callus E, Kutty S, Fieuws S, Moons P, on behalf of the APPROACH-IS consortium and ISACHD. Quality of life of adults
with congenital heart disease in 15 countries: Evaluating country-specific characteristics. J Am Coll Cardiol 2016; 67: 2237-2245.
 
Zhao Y, Ji L, Liu J, Wu J, Wang Y, Shen S, Guo S, Jian R, Chen G, Wei X, Liao W, Kutty S, Liao Y, Bin J. Intensity of Left Atrial Spontaneous Echo Contrast as a Correlate for Stroke Risk Stratification in Patients with Nonvalvular Atrial Fibrillation. Sci Rep. 2016 Jun 9;6:27650.
 
Varghese J, Kutty S, Abdullah I, Hall S, Shostrom V, Hammel JM. Preoperative and Intraoperative Predictive Factors of Immediate Extubation After Neonatal Cardiac Surgery. Ann Thorac Surg June 18, 2016.
 
Chen G, Yang L, Zhong L, Kutty S, Wang Y, Cui K, Xiu J, Cao S, Huang Q, Liao W, Liao Y, Wu J, Zhang W, Bin J. Delivery of Hydrogen Sulfide by Ultrasound Targeted Microbubble Destruction Attenuates Myocardial Ischemia-reperfusion Injury. Sci Rep. 2016 Jul 29;6:30643.
 
Agoston-Coldea L, Kouaho S, Sacre K, Dossier A, Escoubet B, Chillon S, Laissy J-P, Rouzet F, Kutty S, Extramiana F, Leenhardt A, Borie R, Crestani B, Ou P. High mass (> 18 g) of late gadolinium enhancement on CMR imaging is associated with major cardiac events on long-term outcome in patients with biopsy-proven extracardiac sarcoidosis. Int J Cardiol 2016 Jul 30; doi:10.1016/j.ijcard.2016.07.233.
 
Aubart M, Ou P, Elie C, Canniffe C, Kutty S, Delos V, Graffigne C, de Montalembert M, Brousse V. Longitudinal MRI and ferritin monitoring of iron overload in chronically transfused and chelated children with hemoglobinopathies. J Pediatr Hematol Oncol. 2016 Aug.
 
Kowallick JT, Vieira MS, Kutty S, Lotz J, Hasenfuß G, Chiribiri A, Schuster A. Left Atrial Performance in the Course of Hypertrophic Cardiomyopathy: Relation to Left Ventricular Hypertrophy and Fibrosis. Invest Radiol. 2016 September.
 
Callaghan FM, Arnott C, Figtree GA, Kutty S, Celermajer DS, Grieve SM. Quantifying right atrial filling and emptying: A 4D-flow MRI study. J Magn Reson Imaging. 2016 Sep 14. doi: 10.1002/jmri.25457.
 
Cantinotti M, Valverde I, Kutty S. Three-Dimensional Printed Models in Congenital Heart Disease. Int J Cardiovascular Imaging Sept 27, 2016.
 
Ashraf M, Martinez M, McGhee K, Schabel M, Woodward W, Kutty S, Balbach T, Nguyen T, Ritman EL, Nishimura R, Sahn DJ. Semi-Automated Evaluation of Right Ventricular Volumes Using Gradient Cine Magnetic Resonance Data Sets: An In Vitro Validation Study. J Integrative Cardiology, Oct 2016.
 
Cantinotti M, Assanta N, Melo M, Giordano R, Crocetti M, Iervasi G, Kutty S. Strengths, Limitations and Geographical Discrepancies in the Eligibility Criteria for Sport Participation in Young Patients with Congenital Heart Disease. Clin J Sport Medicine 2016.
 
Cantinotti M, Kutty S, Franchi E, Paterni M, Scalese M, Iervasi G, Koestenberger M. Pediatric Echocardiographic Nomograms: What Has Been Done and What Still Needs to be Done. Trends in Cardiovascular Medicine, Jan 19, 2017.
 
McGovern E, Kelleher E, Snow A, Walsh K, Gadallah B, Kutty S, Redmond JM, McMahon CJ. Clinical application of three-dimensional printing to the management of complex univentricular hearts with abnormal systemic or pulmonary venous drainage. Cardiol Young. 2017 Feb 6:1-9.
 
Varghese J, Kutty S, Hall S, Craft M, Abdullah I, Hammel J. Five-Year Experience with Immediate Extubation after Arterial Switch Operations for Transposition of Great Arteries. Eur J Cardiothorac Surg 2017 Feb 10.
 
Cantinotti M, Giordano R, Emdin M, Assanta N, Crocetti M, Marotta M, Iervasi G, Lopez L, Kutty S. Echocardiographic Assessment of Pediatric Semilunar Valve Disease. Echocardiography Mar 2017. 130. Hayes SA, Kutty S, Thomas J, Johnson JT, Yetman AT. Cardiovascular and general health status of adults with Trisomy 21. Int J Cardiol. 2017 Mar 10.
 
Suntratonpipat S, Khoo NS, Colen T, Alhabdan M, Troung D, Zahari N, Kutty S, Smallhorn JF, Tham EB. Impaired Single Right Ventricular Function Compared to Single Left Ventricles during the Early Stages of Palliation: A Longitudinal Study. J Am Soc Echocardiogr. 2017 Mar 3.
 
Tian L, Neuber-Hess M, Mewburn J, Dasgupta A, Dunham-Snary K, Wu D, Chen KH, Hong Z, Sharp WW, Kutty S, Archer SL. Ischemia-induced Drp1 and Fis1-mediated mitochondrial fission and right ventricular dysfunction in pulmonary hypertension. J Mol Med (Berl). 2017 Apr;95(4):381-393.