Biju Bhargavan, PhD, Biographical Information

PhD, Central Drug Research Institute, 2009Biju Bhargavan
Lucknow, India 

Phone: 

E-mail: Biju Bhargavan

Positions and Employment
Professional Membership
Honors
Peer Review Activities
Patents
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Positions and Employment

2016-Present Instructor, Department of Pharmacology and Experimental Neuroscience, UNMC
2014-2016 Senior Research Associate, Department of Pharmacology and Experimental Neuroscience, UNMC
2012-2014 Post Doctoral Research Associate, Department of Pharmacology and Experimental Neuroscience, UNMC
2006-2009 Senior Research Fellow, Division of Endocrinology, Central Drug Research Institute, Lucknow, India
2004-2006 Junior Research Fellow, Division of Endocrinology, Central Drug Research Institute, Lucknow, India
2003-2004 Project Fellow, Department of Zoology, University of kerala, Trivandrum, India

Professional Memberships

2011- Member, The Association for Research in Vision & Ophthalmology (ARVO)

2016- Member, International Society for Neuro Virology (ISNV)

2017- Life time Member, Indian Society for Bone and Mineral Research


Honors

2004- National Eligibility Test (NET), Lectureship, Council of Scientific and Industrial Research (CSIR), Govt. of India 

2004- Junior Research Fellowship, Council of Scientific and Industrial Research (CSIR), Govt. of India

2006- Senior Research Fellowship, Council of Scientific and Industrial Research (CSIR), Govt. of India


Peer Review Activities

2016- Molecular Neurobiology, AIDS Clinical Research & STDs, BMC Cell Biology, and CNS Neuroscience & Therapeutics


Patents Filed

Maurya, R., Singh, G., Narayana Murthy, P.S., Mehrotra, S., Singh, D., Biju, B., and Singh, M.M.(2006). Antiosteoporosis activity of Butea species. Patent appl. no. 0522DEL2006, India: CSIR-DBT.

Maurya, R., Singh, G., Narayana Murthy, P.S., Mehrotra, S., Singh, D., Biju, B., and Singh, M.M.(2008). Pharmaceutical Composition Containing Butea Isoflavones for the Prevention/Treatment of Bone Disorders and a Process for the Preparation Thereof. Canadian Patent. PCT/IB2007/000468, WO 2007/099432 A3.

Maurya, R., Singh, G., Narayana Murthy, P.S., Mehrotra, S., Singh, D., Biju, B., and Singh, M.M.(2009).Pharmaceutical Composition for the Prevention/Treatment of Bone Disorders and a Process for the Preparation Thereof. US patent, CPS and International class: A61K. Application no. 20090221690, Current US class:514/453, Kinda code:A1.

Rakesh Maurya, Geetu Singh, Pandruvada Subramanyam Narayana Murthy, Sandhya Mehrotra, Divya Singh, Biju Bargavan and Man Mohan Singh. Pharmaceutical composition containing Butea isoflavones for the prevention/treatment of bone disorders and a process for the preparation thereof. Japanese Application No.: 2008-556868 Date of Filing: 28-Aug-08.


Oral Presentations at Scientific Meetings/Congresses

ARVO presentation "Epigenetic Repression of LEDGF Gene by UVB Stress Requires Histone H3 Lysine 9 dimethylation Recruitment at CpG Island in its Gene Promoter," Florida 2011

National Symposium on "Current Trends in Comparative Endocrinology Impact of Molecular Biology and Biotechnology," Nagpur on November 27-29, 2003, organized by Department of Zoology, Nagpur University Campus, Nagpur.

Department of Dentistry on "Development of osteogenic agents from natural resources," New York University, January 2012.

Department of Ophthalmology & Visual Sciences "Skeletal system control on male fertility, "University of Nebraska Medical Center, Omaha, USA on , January 2011


Abstracts/Conference Papers

  1. Biju Bhargavan, Georgette D. Kanmogne. HIV-1InfectionUpregulatesToll-LikeReceptor-3ExpressionInThe Human Brain Endothelium. J. Neurovirol. (2018) 24 (Suppl 1):S1–S102.
  2. Biju Bhargavan, Georgette D. Kanmogne. Toll-Like Receptor-3 Mediates HIV-1-Induced Interleukin-6 Expression In The Human Brain Endothelium Via TAK1 And JNK Pathways. J. Neurovirol. (2018) 24 (Suppl 1):S1–S102.
  3. Bhargavan B, and Kanmogne GD. Differential Mechanisms of Inflammation and Endothelial Dysfunction by HIV-1 Subtype-B and Recombinant CRF02_AG Tat Proteins on Human Brain Microvascular Endothelial Cells. J Neurovirol., 2016; 22 (Suppl1):S1-S89.
  4. Biju Bhargavan, Nigar Fatma, Eri Kubo, Bhavana K. Chhunchha,Dhirendra P. Singh. Epigenetic Repression of LEDGF Gene by UVB Stress Requires Histone H3 Lysine 9 Dimethylation Recruitment at CpG Island in its Gene Promoter. Ophthalmol. Vis. Sci.. 2011; 52(14):5288.
  5. Biju Bhargavan, Nigar Fatma, Bhavana Chhunchha, Eri Kubo and Dhirendra P. Singh. LEDGF and prostate cancer: LEDGF SiRNA delivery decelerate tumorigenesis and invasiveness of prostate cancer cells. Abstract ID:52, Cancer Biology and Genetics, CPRIT (2011), Austin, Texas.
  6. Biju Bhargavan, Nigar Fatma, Bhavana Chhunchha, Eri Kubo, K.K. Sharma and Dhirendra P. Singh. Oxidative Stress and Age-Dependent Expression of LEDGFin Eye Lens or Lens Epithelial Cells is Associated with Methylation of GC Box Elements in Its Gene Promoter. Ophthalmol. Vis. Sci.. 2012; 53(14):1040.
  7. Dhirendra P. Singh, Bhavana K. Chhunchha, Biju Bhargavan, Nigar Fatma. Methylation of CpG Island in Aging Lens Epithelial Cells And During Oxidative Stress Affects Sp1 Binding And Activity in LEDGF Promoter. Ophthalmol. Vis. Sci.. 2013; 54(15):481.
  8. Dhirendra P. Singh, Yoshihiro Takamura, Bhavana K. Chhunchha, Nigar Fatma, Biju Bhargavan, Eri Kubo. Characterization of Lens Epithelium Derived-Protein/132, a Novel Guanine Exchange Factor for ARFs, and Its Role in ER and Golgi Homeostasis. Ophthalmol. Vis. Sci.. 2011; 52(14):1527.
  9. Bhavana K. Chhunchha, Nigar Fatma, Eri Kubo, Biju Bhargavan, Dhirendra P. Singh. Sp1-Dependent Enhanced Prdx6 Transcription: A Novel Action of Curcumin in Protecting Lens Epithelial Cells Against Oxidative Stress. Ophthalmol. Vis. Sci.. 2011; 52(14):1549.
  10. Nigar Fatma, Eri Kubo, Keiichi Ishihara, Bhavana Chhunchha, Biju Bhargavan, Dhirendra P. Singh. C-terminal Region of Human LEDGF Binds to N-terminal HSF1 to Activate Small Hsps Transcription in Heat Stress. Ophthalmol. Vis. Sci.. 2011; 52(14):2783.
  11. Chhunchha B, Fatma N, Kubo E, Bhargavan B, Singh DP. Sumoylation Modulates Prdx6 Cytoprotective Activity and Inhibits Its Sp1-Dependent Transcription. Ophthalmol. Vis. Sci..2012; 53(14):1071.
  12. Singh DP, Fatma N, Chhunchha B, Bhargavan B, Kubo E. A N-terminal Domain in the Guanine Nucleotide Exchange Factor LEDP/132 Regulates ADP-Ribodylation Factor 1-Mediated Protection of Lens Epithelial cells Against ER Stress. Ophthalmol. Vis. Sci.. 2012; 53(14):1062.
  13. Fatma N, Kubo E, Chhunchha B, Bhargavan B, Singh DP. Prdx6-Deficiency in Lens Epithelai Cells Causes Oxidative Stress-Related Altered Expression of MicroRNAs:Role of MiRNA22. Ophthalmol. Vis. Sci.. 2012; 53(14):1041.
  14. Singh, B. Bhargavan, A. Gautam, M. Singh, A. Kumar, S. Chaurasia, A. Tyagi, D. Yadav, A. Goel, R. Maurya, N. Chattopadhyay. Effects of methoxy-isoflavones in osteoblast function and acquisition of peak bone mass (PBM). 8th European Congress on Menopause (EMAS) /Maturitas 63, Supplement 1 (2009) S1–S136.
  15. Singh, N. Chattopadhyay, B. Bhargavan, A. Gautam, M. Singh, R. Maurya, A. Goel, G. Jain, S. Sanyal. Characterization of a New Bone Forming Agent (CDROSTEOID) From Natural Source (2009). Osteoporos Int. 20 (Suppl 1):S23–S176.

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