Debashis Dutta, PhD

Debashis Dutta, PhDDebashis_Dutta.jpg
Instructor
 
Laboratory Huangui Xiong, MD, PhD
Durham Research Center
985880 Nebraska Medical Center
Omaha, NE 68198-5880
 
Keywords: HIV-1, SARS-CoV-2, NLRP3 inflammasome, Neuroinflammation, Neuroimmunology, Neurodegeneration, and HIV-1 associated neurocognitive disorder (HAND,) and Drug of Abuse
 
Research Interests
On-going projects
Publications
Dr. Dutta's biographical information

Research Interests

My research interest is broadly in infectious diseases and emerging pathogens, molecular biology of pathogens, and immune responses by host. Inflammation and hyperinflammation induced by pathogens, specifically NLRP3 inflammasome.

1) Molecular mechanism underlying HIV-1 associated neurocognitive disorders (HAND).
2) Effect of drug abuse especially methamphetamine in HAND pathogenesis.
3) Mechanisms of SARS-CoV-2 induced NLRP3 inflammasome mediated hyperinflammation and cytokine storm in brain immune cells, microglia.


Ongoing Projects

K channel, NLRP3 inflammasome and Meth exacerbation of HAND

To investigate mechanisms of how methamphetamine (drug abuse) potentiates HIV-1 induced microglial NLRP3 inflammasome activation leading to neuroinflammation in the era of combined antiretroviral therapy (cART).



Publications

  1. Pino M, Abid T, Pereira Ribeiro S, Edara VV, Floyd K, Smith JC, Latif MB, Pacheco-Sanchez G, Dutta D, Wang S, Gumber S, Kirejczyk S, Cohen J, Stammen RL, Jean SM, Wood JS, Connor-Stroud F, Pollet J, Chen WH, Wei J, Zhan B, Lee J, Liu Z, Strych U, Shenvi N, Easley K, Weiskopf D, Sette A, Pollara J, Mielke D, Gao H, Eisel N, LaBranche CC, Shen X, Ferrari G, Tomaras GD, Montefiori DC, Sekaly RP, Vanderford TH, Tomai MA, Fox CB, Suthar MS, Kozlowski PA, Hotez PJ, Paiardini M, Bottazzi ME, Kasturi SP. A yeast expressed RBD-based SARS-CoV-2 vaccine formulated with 3M-052-alum adjuvant promotes protective efficacy in non-human primates. Sci Immunol. 2021 Jul 15;6(61): eabh3634. doi: 10.1126/sciimmunol. Abh 3634. PMID: 34266981.
  2. Machhi J, Herskovitz J, Senan AM, Dutta D, Nath B, Oleynikov MD, Blomberg WR, Meigs DD, Hasan M, Patel M, Kline P, Chang RC, Chang L, Gendelman HE, Kevadiya BD. The Natural History, Pathobiology, and Clinical Manifestations of SARS-CoV-2 Infections. J Neuroimmune Pharmacol doi:10.1007/s11481-020-09944-5.
  3. Dutta D, Srivastava V, Tripathi A, Singh V, Ansari MM, Pant G, Mishra M, Sharma S, Thota JR, Singh PK, Singh BN. Mycobacterium bovis sigF mutant exhibits altered surface phenotype and compromised pathogenesis. Tuberculosis (Edinb) 118:101855.
  4. Bidokhti MRM, Dutta D, Madduri LSV, Woollard SM, Norgren R, Jr., Giavedoni L, Byrareddy SN. SIV/SHIV-Zika co-infection does not alter disease pathogenesis in adult non-pregnant rhesus macaque model. PLoS Negl Trop Dis 12:e0006811. (¶Equal contribution).
  5. Woollard SM, Olwenyi OA, Dutta D, Dave RS, Mathews S, Gorantla S, Johnson N, Giavedoni L, Norgren RB, Jr., Byrareddy SN. Preliminary Studies on Immune Response and Viral Pathogenesis of Zika Virus in Rhesus Macaques. Pathogens 7. (¶Equal contribution).
  6. Dutta D, Johnson S, Dalal A, Deymier MJ, Hunter E, Byrareddy SN. High throughput generation and characterization of replication-competent clade C transmitter-founder simian human immunodeficiency viruses. PLoS One 13:e0196942.
  7. Basiri A, Xiao M, McCarthy A, Dutta D, Byrareddy SN, Conda-Sheridan M. Design and synthesis of new piperidone grafted acetylcholinesterase inhibitors. Bioorg Med Chem Lett 27:228-231.
  8. Rai AK, Dubey AP, Kumar S, Dutta D, Mishra MN, Singh BN, Tripathi AK. Carotenoid Biosynthetic Pathways Are Regulated by a Network of Multiple Cascades of Alternative Sigma Factors in Azospirillum brasilense Sp7. J Bacteriol 198:2955-2964.
  9. Singh AK, Dutta D, Singh V, Srivastava V, Biswas RK, Singh BN. Characterization of Mycobacterium smegmatis sigF mutant and its regulon: overexpression of SigF antagonist (MSMEG_1803) in M. smegmatis mimics sigF mutant phenotype, loss of pigmentation, and sensitivity to oxidative stress. Microbiologyopen 4:896-916. (¶Equal contribution).
  10. Biswas RK, Dutta D, Tripathi A, Feng Y, Banerjee M, Singh BN. Identification and characterization of Rv0494: a fatty acid-responsive protein of the GntR/FadR family from Mycobacterium tuberculosis. Microbiology 159:913-923.
 

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Dr. Dutta's biographical information.