Saumi Mathews, PhD

Saumi Mathews, PhDSaumi_Mathews
Instructor
 
Laboratory of Santhi Gorantla, PhD
Durham Research Center 8068
985880 Nebraska Medical Center
Omaha, NE 68198-5880
 
Keywords: Mouse models for HIV, Humanized mouse, HIV pathogenesis, Stem cells, neuro-AIDS, anti-retroviral therapy (ART), Drugs of abuse.
 
In the News
Research Interests
On-going projects
Publications

In the News
UNMC Today| January 04, 2020
New Faculty
 
UNMC Today| July 03, 2019
For first time ever, researchers able to eliminate HIV from animal
 
UNMC Today | February 06, 2018
Chemically modified drug shows promise for HIV treatment, elimination
 

Research Interests

The goal of my current research focuses on (a) the development of humanized mouse models for translational research, specifically HIV and HIV associated neurocognitive disorders, (b) identifying the location of the HIV sanctuaries in the brain, and the viral rebound upon cessation of anti-retroviral therapy, (c) understanding the molecular mechanism of host-pathogen interaction to develop therapeutic strategies against HIV, (d) using humanized mouse models that mimic the biology of HIV infection to understand the role of the substance of abuse such as cocaine in establishing HIV reservoirs.

Ongoing Projects

Humanized microglia mouse as a tool to monitor HIV brain reservoirs and effects of substance abuse and HIV associated neurocognitive disorders


Publications

  1. Ganesan M, Mathews S, Makarov E, Petrosyan A, Kharbanda KK, Kidambi S, Poluektova LY, Casey CA, Osna NA. Acetaldehyde suppresses HBV-MHC class I complex presentation on hepatocytes via induction of ER stress and Golgi fragmentation. Am J Physiol Gastrointest Liver Physiol. 2020 Oct 1;319(4): G432-G442. doi: 10.1152/ajpgi.00109.2020. Epub 2020 Aug 5. PMID: 32755306; PMCID: PMC7654643.
  2. Ganesan M, Krutik VM, Makarov E, Mathews S, Kharbanda KK, Poluektova LY, Casey CA, Osna NA. Acetaldehyde suppresses the display of HBV-MHC class I complexes on HBV-expressing hepatocytes. Am J Physiol Gastrointest Liver Physiol. 2019 Aug 1;317(2): G127-G140. doi: 10.1152/ajpgi.00064.2019. Epub 2019 May 29. PMID: 31141391; PMCID: PMC6734374.
  3. Dash PK, Kaminski R, Bella R, Su H, Mathews S, Ahooyi TM, Chen C, Mancuso P, Sariyer R, Ferrante P, Donadoni M, Robinson JA, Sillman B, Lin Z, Hilaire JR, Banoub M, Elango M, Gautam N, Mosley RL, Poluektova LY, McMillan J, Bade AN, Gorantla S, Sariyer IK, Burdo TH, Young WB, Amini S, Gordon J, Jacobson JM, Edagwa B, Khalili K, Gendelman HE. Sequential LASER ART and CRISPR Treatments Eliminate HIV-1 in a Subset of Infected Humanized Mice. Nat Commun. 2019 Jul 2;10(1):2753. doi: 10.1038/s41467-019-10366-y. PMID: 31266936; PMCID: PMC6606613.
  4. Mathews S, Branch Woods A, Katano I, Makarov E, Thomas MB, Gendelman HE, Poluektova LY, Ito M, Gorantla S. Human Interleukin-34 facilitates microglia-like cell differentiation and persistent HIV-1 infection in humanized mice. Mol Neurodegener. 2019 Mar 5;14(1):12. doi: 10.1186/s13024-019-0311-y. PMID: 30832693; PMCID: PMC6399898.
  5. Su H, Cheng Y, Sravanam S, Mathews S, Gorantla S, Poluektova LY, Dash PK, Gendelman HE. Immune Activations and Viral Tissue Compartmentalization During Progressive HIV-1 Infection of Humanized Mice. Front Immunol. 2019 Feb 28; 10:340. doi: 10.3389/fimmu.2019.00340. PMID: 30873181; PMCID: PMC6403174.
  6. Dagur RS*, Branch-Woods A*, Mathews S*, Joshi PS, Quadros RM, Harms DW, Cheng Y, Miles SM, Pirruccello SJ, Gurumurthy CB, Gorantla S, Poluektova LY. Human-like NSG mouse glycoproteins sialylation pattern changes the phenotype of human lymphocytes and sensitivity to HIV-1 infection. BMC Immunol. 2019 Jan 7;20(1):2. doi: 10.1186/s12865-018-0279-3. PMID: 30616506; PMCID: PMC6322283.
  7. Woollard SM, Olwenyi OA, Dutta D, Dave RS, Mathews S, Gorantla S, Johnson N, Giavedoni L, Norgren RB Jr, Byrareddy SN. Preliminary Studies on Immune Response and Viral Pathogenesis of Zika Virus in Rhesus Macaques. Pathogens. 2018 Aug 20;7(3):70. doi: 10.3390/pathogens7030070. PMID: 30127237; PMCID: PMC6160936.
  8. Sillman B, Bade AN, Dash PK, Bhargavan B, Kocher T, Mathews S, Su H, Kanmogne GD, Poluektova LY, Gorantla S, McMillan J, Gautam N, Alnouti Y, Edagwa B, Gendelman HE. Creation of a long-acting nanoformulated dolutegravir. Nat Commun. 2018 Feb 6;9(1):443. doi: 10.1038/s41467-018-02885-x. PMID: 29402886; PMCID: PMC5799307.

Additional publications in PubMed.

 

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