Rajesh Rajaiah, PhD

rajesh_rajaiah.jpgRajesh Rajaiah, PhD

Laboratory of Siddappa Byrareddy, PhD

Durham Research Center 8058
985800 Nebraska Medical Center
Omaha, NE 68198-5880

Keywords: SARS-CoV-2, immunomodulation, cytokines, inflammation

Research interests
Representative publications
Biographical information

Research interests

My research focuses on understanding the immunopathogenesis of SARS-CoV-2/HIV/SIV using a small animal model. And also, I am interested in understanding the immune response in sterile inflammation to develop therapeutic strategies to treat inflammatory diseases.

Representative publications 

  1. Pandey K, Thurman M, Johnson SD, Acharya A, Johnston M, Klug EA, Olwenyi, OA, Rajaiah R, Byrareddy SN. Mental Health Issues During and After COVID-19 Vaccine Era. Brain Res Bull. 2021 Sep 3;176:161-173. (review article).
  2. Rudresha GV, Urs AP, Manjuprasanna VN, Gowda MDM, Jayachandra K, Rajaiah R*, Vishwanath BS*. Echis carinatus snake venom metalloprotease-induced toxicities in mice: Therapeutic intervention by a repurposed drug, Tetraethyl thiuram disulfide (Disulfiram). PLoS Negl Trop Dis. 2021 Feb 2;15(2):e0008596.
  3. Urs AP, Manjuprasanna VN, Rudresha GV, Hiremath V, Sharanappa P, Rajaiah R*, Vishwanath BS. Thrombin-like serine protease, antiquorin from Euphorbia antiquorum latex induces platelet aggregation via PAR1-Akt/p38 signaling axis. Biochim Biophys Acta Mol Cell Res. 2021 Mar;1868(3):118925.
  4. Rajaiah R*, Abhilasha KV, Shekar MA, Vogel SN, Vishwanath BS*. Evaluation of mechanisms of action of re-purposed drugs for treatment of COVID-19. Cellular Immunology 2020; 358: 104240. (review article).
  5. Haile LA, Polumuri SK, Rao R, Kelley-Baker L, Kryndushkin D, Rajaiah R, Israely T, Rao VA, Verthelyi D. Cell based assay identifies TLR2 and TLR4 stimulating impurities in interferon beta. Scientific Reports. 2017; 7 (1): 10490.
  6. Perkins DJ, Rajaiah R, Tennant SM, Ramachandran G, Higginson EE, Dyson TN, Vogel SN. Salmonella typhimurium Co-opts the Host Type I Interferon System to Selectively Restrict Macrophage Innate Immune Transcriptional Responses (2015). J Immunol. 2015;195(5):2461-71.
  7. Rajaiah R, Perkins DJ, Ireland DD, Vogel SN. CD14 Dependence of TLR4 Endocytosis and TRIF Signaling Displays Ligand Specificity and Is Dissociable in Endotoxin Tolerance (2015). Proc Natl Acad Sci U S A. 2015;112(27):8391-6.
  8. Rajaiah R, Perkins DJ, Polumuri SK, Zhao A, Keegan AD, Vogel SN. Dissociation of Endotoxin tolerance and alternatively activated macrophage. J Immuno 2013;190(9):4763-72.
  9. Yang YH, Rajaiah R, Ruoslahti E, Moudgil KD. Peptides targeting the inflamed synovial vasculature attenuate ongoing autoimmune arthritis. Proc Natl Acad Sci U S A 2011, 108(31):12857-62).
  10. Venkatesha SH, Yu H, Rajaiah R, Tong L, Moudgil KD. Celastrus-derived celastrol suppresses autoimmune arthritis by modulating antigen-induced cellular and humoral effector responses. J Biol Chem.  2011; 286(17):15138-46.  
  11. Yu H, Yang YH, Rajaiah R, Moudgil KD. Nicotine-induced differential modulation of autoimmune arthritis in the Lewis rat involves changes in IL-17 and anti-citrullinated cyclic peptide antibodie Arthritis Rheum. 2011; 63(4):981-91.
  12. Rajaiah R, Puttabyatappa M, Polumuri SK, Moudgil KD. Interleukin-27 and IFN-gamma are involved in regulation of autoimmune arthr J Biol Chem.2011; 286(4):2817-25.
  13. Rajaiah R and Moudgil KD. Heat shock proteins can promote as well as regulate inflammation in autoimmunity. Autoimmun Rev. 2009, 8(5):388-9 (Review).

Biographical information

Positions and Employment

2021- present: Instructor, Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, Nebraska

2016- 2021: Assistant Professor, Department of Studies in Molecular Biology, University of Mysore, Manasagangotri, Mysore, India

2014-2016: ORISE fellow, CDER, Food and Drug Administration, Silver Spring, Maryland

2006-2014: Postdoctoral fellow, Department of Microbiology and Immunology, University of Maryland Baltimore, Baltimore, Maryland

2001-2006: PhD student in Biochemistry, Department of Studies in Biochemistry, University of Mysore, Manasagangotri, Mysore, India