Annadurai Thangaraj, PhD
Durham Research Center 8024
985880 Nebraska Medical Center
Omaha, NE 68198-5880
Keywords: Drugs of abuse and HIV
Despite the effectiveness of cART in controlling viremia, almost 80 50% of the infected individuals continue to be afflicted with a spectrum of neurological symptoms called HAND, which affects the healthy living of HIV infected patients. Dysfunctional or damaged mitochondria could promote microglia activation, cellular senescence and “inflamm-aging” through increased production of reactive oxygen species and inflammatory mediators, which could be potential contributor of HAND and accelerated aging in HIV patients. Interventions aimed at blocking neuroinflammation could provide promising therapeutic targets and supportive in health living of HIV infected patients.
In view of that, my research focuses in the area of HIV and Drugs of abuse mediated neurological disorder and accelerated aging in the context of mitochondria dysfunction.
My research goal is to elucidate the cellular and molecular mechanisms underlying in HIV and drug abuse mediated glial activation and senescence through deciphering the cellular events such as mitochondrial damage, metabolism, oxidative stress and defective clearance of damaged mitochondria through mitophagy pathway. My current research focus is to explore HIV and Cocaine mediated microglial activation, cellular senescence and chronic neuro-inflammation, in a specific focus on SIRT3-dependent mitochondrial antioxidant failure and defective mitophagy pathway. My research focus also included with unravelling the novel molecular therapeutic targets and its therapeutics.
In the long run, my aim is to remain explore the molecular mechanisms in close association with clinical side to identify potential therapeutic strategies for HAND treatment and ensuring my research findings into translational level.
- Thangaraj A, Periyasamy P, Guo ML, Chivero ET, Callen S, Buch S. Mitigation of cocaine-mediated mitochondrial damage, defective mitophagy and microglial activation by superoxide dismutase mimetics. Autophagy. 2019 Apr 16:1-24. PMID: 30990365.
- Tripathi A, Thangaraj A, Chivero ET, Periyasamy P, Callen S, Burkovetskaya ME, Guo ML, Buch S. Antiretroviral-Mediated Microglial Activation Involves Dysregulated Autophagy and Lysosomal Dysfunction. Cells. 2019 Sep 28;8(10). pii: E1168. doi: 10.3390/cells8101168. PMID: 31569373
- Chivero ET, Ahmad R, Thangaraj A, Periyasamy P, Kumar B, Kroeger E, Feng D, Guo ML, Roy S, Dhawan P, Singh AB, Buch S. Cocaine Induces Inflammatory Gut Milieu by Compromising the Mucosal Barrier Integrity and Altering the Gut Microbiota Colonization. Sci Rep. 2019 Aug 21;9(1):12187. doi: 10.1038/s41598-019-48428-2. PMID: 31434922.
- Periyasamy P, Thangaraj A, Bendi VS, Buch S. HIV-1 Tat-mediated microglial inflammation involves a novel miRNA-34a-NLRC5-NFκB signaling axis. Brain Behav Immun. 2019 Aug; 80:227-237. PMID: 30872089
- Annadurai Thangaraj, Palsamy Periyasamy, Venkata Sunil Bendi, Shannon Callen, Gurudutt Pendyala and Shilpa Buch. HIV-1 TAT mediated microglial activation: Role of mitochondrial dysfunction and defective mitophagy. Autophagy. 2018;14(9):1596-1619.
- Periyasamy P, Thangaraj A, Guo ML, Hu G, Callen S, Buch S. Epigenetic Promoter DNA Methylation of miR-124 Promotes HIV-1 Tat-Mediated Microglial Activation via MECP2-STAT3 Axis. J Neurosci. 2018 Jun 6;38(23):5367-5383.
- Susmita Sil, Palsamy Periyasamy, Annadurai Thangaraj, Ernest T. Chivero and Shilpa Buch, PDGF/PDGFR axis in the neural systems. Mol Aspects Med. 2018 Aug;62:63-74.