Xinglong Wang's laboratory


Research Goals
Collaborators
Funding
Techniques used in the lab
Personnel
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Lab phone: 402-559-7758


Research Goals

Genetic mutations in TAR DNA-binding protein 43 (TDP-43) cause ALS and FTD, and the increased presence of TDP-43 in the cytoplasm is a prominent histopathological feature of degenerating neurons in ALS, FTD and AD. One major focus of our current research is about the molecular pathomechanisms of TDP-43. Mitochondrial dysfunction has long been recognized as a prominent feature of AD, FTD, and ALS. However, the mechanisms responsible for the mitochondrial impairment, and its role in these diseases were not clear. Mitochondria are dynamic organelles that undergo continual fission and fusion events which serve crucial physiological function. Another focus of our research is the potential role of mitochondria dynamics in mitochondrial dysfunction and neurodegeneration in FTD and ALS.



Collaborators

Dr. George Perry, Department of Biology, The University of Texas at San Antonio
Dr. Masaru Miyagi, Department of Pharmacology, Case Western Reserve University
Dr. Xiaofeng Zhu, Department of Population and Quantitative Health Sciences, Case Western Reserve University
Dr. Hu Li, Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic College of Medicine


Funding

Mitochondrial modulation of neuroinflammation in AD and related tauopathies
PI: Wang, X
Source: NIH/NIA RF1AG065342
The major goals of this project are to study the interplays between neuronal Mfn2 and neuroinflammation tau transgenic models.

FAM222A and amyloid plaque deposition in Alzheimer's Disease
PI: Wang, X
Source: NIH/NIA RF1AG066578
The major goals of this project are to study the FAM222A in amyloid deposition in AD.

Mitochondrial TDP-43 in Alzheimer's Disease
PI: Wang, X
Source: NIH/NIA RF1AG056320
The major goals of this project are to study mitochondrial associated TDP-43 in the pathogenies of AD

Mitochondrial dynamics for the maintenance of neuromuscular junctions during aging and in ALS
PI: Wang, X
Source: NIH/NINDS R01NS097679
The major goals of this project are to study the role of mitochondrial dynamics in the regulation of NMJs



Techniques used in laboratory


Personnel

Justin Dunn
Research Technician II


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Ju Gao, PhD
Research Associate


 Ju Gao, PhD
Ariele Peters
Lab Manager
Research Technologist I

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Xiaojia Ren, PhD
Postdoctoral Scholar


 

 Xiaojia Ren

Devanshi Shukla
Graduate Research Assistant
IGPBS Neuroscience


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Luwen Wang, PhD
Research Associate


 

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